YNL108C_p

Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL108C / YNL108C

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:4.69|P-value:9.06E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.61|P-value:1.27E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:5.36|P-value:4.74E-7 ID:SGTC_599|Compound:1935-0052|FD-Score:3.48|P-value:7.24E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.04|P-value:1.11E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.25|P-value:7.91E-7 ID:SGTC_638|Compound:3970-0837|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.67|P-value:3.84E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.42|P-value:2.66E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.74|P-value:7.25E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:3.63|P-value:4.57E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.02|P-value:1.19E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.92|P-value:1.62E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.43|P-value:2.53E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:5.77|P-value:6.44E-8 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.28|P-value:4.55E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.40|P-value:9.44E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.14|P-value:7.66E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.51|P-value:6.65E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.54|P-value:6.14E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:5.31|P-value:6.04E-7 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.41|P-value:9.19E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.08|P-value:9.41E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.78|P-value:6.25E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.57|P-value:5.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:5.40|P-value:3.96E-7 ID:SGTC_1752|Compound:st044819|FD-Score:4.69|P-value:9.08E-6 ID:SGTC_1779|Compound:st039427|FD-Score:-4.35|P-value:3.42E-5 ID:SGTC_1783|Compound:st039459|FD-Score:-3.63|P-value:4.46E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.15|P-value:1.26E-6 ID:SGTC_1915|Compound:st067105|FD-Score:4.42|P-value:2.62E-5 ID:SGTC_1960|Compound:st011366|FD-Score:3.80|P-value:2.61E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.93|P-value:1.63E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.49|P-value:7.14E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.51|P-value:1.84E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.60|P-value:5.04E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.39|P-value:9.56E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.58|P-value:5.33E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.56|P-value:5.60E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.12|P-value:8.07E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.77|P-value:2.83E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.74|P-value:7.31E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.70|P-value:3.58E-4 ID:SGTC_2942|Compound:9052777|FD-Score:9.75|P-value:2.38E-19 ID:SGTC_2947|Compound:9072639|FD-Score:3.40|P-value:9.38E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.48|P-value:2.14E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.63|P-value:4.57E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.73|P-value:8.01E-8 ID:SGTC_52|Compound:0329-0193|FD-Score:4.69|P-value:9.06E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.61|P-value:1.27E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:5.36|P-value:4.74E-7 ID:SGTC_599|Compound:1935-0052|FD-Score:3.48|P-value:7.24E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.04|P-value:1.11E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.25|P-value:7.91E-7 ID:SGTC_638|Compound:3970-0837|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.67|P-value:3.84E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.42|P-value:2.66E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.74|P-value:7.25E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:3.63|P-value:4.57E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.02|P-value:1.19E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.92|P-value:1.62E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.43|P-value:2.53E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:5.77|P-value:6.44E-8 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.28|P-value:4.55E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.40|P-value:9.44E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.14|P-value:7.66E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.51|P-value:6.65E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.54|P-value:6.14E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:5.31|P-value:6.04E-7 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.41|P-value:9.19E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:4.08|P-value:9.41E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.78|P-value:6.25E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.57|P-value:5.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:5.40|P-value:3.96E-7 ID:SGTC_1752|Compound:st044819|FD-Score:4.69|P-value:9.08E-6 ID:SGTC_1779|Compound:st039427|FD-Score:-4.35|P-value:3.42E-5 ID:SGTC_1783|Compound:st039459|FD-Score:-3.63|P-value:4.46E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.15|P-value:1.26E-6 ID:SGTC_1915|Compound:st067105|FD-Score:4.42|P-value:2.62E-5 ID:SGTC_1960|Compound:st011366|FD-Score:3.80|P-value:2.61E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.93|P-value:1.63E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.49|P-value:7.14E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.51|P-value:1.84E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.60|P-value:5.04E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.39|P-value:9.56E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.58|P-value:5.33E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.56|P-value:5.60E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.12|P-value:8.07E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.77|P-value:2.83E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.74|P-value:7.31E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.70|P-value:3.58E-4 ID:SGTC_2942|Compound:9052777|FD-Score:9.75|P-value:2.38E-19 ID:SGTC_2947|Compound:9072639|FD-Score:3.40|P-value:9.38E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.48|P-value:2.14E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.63|P-value:4.57E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.73|P-value:8.01E-8

Top fitness defect scores for YNL108C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2942 9052777 9.75 62.2 µM 2.38E-19 1 9.38E-23
2 SGTC_975 1335-0046 5.77 28.5 µM 6.44E-8 RPP1 & pyrimidine depletion 10 3.86E-9
3 SGTC_3247 9135149 5.73 49.5 µM 8.01E-8 DNA damage response 14 5.01E-9
4 SGTC_1747 st037496 5.40 66.6 µM 3.96E-7 6 3.35E-8
5 SGTC_285 1486-1325 5.36 46.0 µM 4.74E-7 12 4.15E-8
6 SGTC_1323 1348-1351 5.31 11.2 µM 6.04E-7 1 5.53E-8
7 SGTC_632 0781-2353 5.25 4.7 µM 7.91E-7 Golgi 15 7.61E-8
8 SGTC_1909 st060837 5.15 51.5 µM 1.26E-6 27 1.33E-7
9 SGTC_1521 st012942 4.78 49.4 µM 6.25E-6 16 8.86E-7
10 SGTC_2926 9010726 4.74 65.2 µM 7.31E-6 18 1.07E-6
11 SGTC_52 0329-0193 4.69 875.0 nM 9.06E-6 TSC3-RPN4 17 1.38E-6
12 SGTC_1752 st044819 4.69 83.0 µM 9.08E-6 13 1.38E-6
13 SGTC_208 k072-0098 4.61 12.4 µM 1.27E-5 heme biosynthesis & mitochondrial translocase 28 2.06E-6
14 SGTC_2951 9072950 4.48 58.1 µM 2.14E-5 ERG2 15 3.82E-6
15 SGTC_970 1315-0089 4.43 19.5 µM 2.53E-5 RSC & ERG11 14 4.65E-6
16 SGTC_1915 st067105 4.42 30.6 µM 2.62E-5 RNA pol III & RNase P/MRP 26 4.85E-6
17 SGTC_706 4262-0057 4.42 46.9 µM 2.66E-5 fatty acid desaturase (OLE1) 19 4.94E-6
18 SGTC_1034 k072-0165 4.28 12.7 µM 4.55E-5 Golgi 15 9.34E-6
19 SGTC_1272 0839-0021 4.14 27.0 µM 7.66E-5 14 1.73E-5
20 SGTC_1482 3346-2049 4.08 8.5 µM 9.41E-5 26 2.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.30E-13 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.113 6.32E-11 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.112 6.51E-11 YOL006C TOP1 hom Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.110 1.91E-10 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.103 1.94E-9 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.101 4.33E-9 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.091 1.37E-7 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
0.091 1.42E-7 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.091 1.47E-7 YDR037W KRS1 het Lysyl-tRNA synthetase
0.088 2.95E-7 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.085 7.35E-7 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.084 1.33E-6 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.35E-6 YER128W VFA1 hom Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
0.083 1.41E-6 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.082 2.16E-6 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases