YNL109W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL109W / YNL109W

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.13|P-value:9.39E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.34|P-value:4.11E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.13|P-value:9.43E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.22|P-value:1.22E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.37|P-value:4.08E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.09|P-value:2.45E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.02|P-value:3.34E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.65|P-value:1.47E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.24|P-value:6.60E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.10|P-value:9.51E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.43|P-value:5.41E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.10|P-value:9.40E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.92|P-value:4.99E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.35|P-value:4.47E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.35|P-value:5.36E-8 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.42|P-value:3.58E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.02|P-value:3.27E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.99|P-value:3.31E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.31|P-value:5.11E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.41|P-value:3.14E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.24|P-value:6.46E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.13|P-value:1.81E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.92|P-value:4.95E-5 ID:SGTC_1921|Compound:5740136|FD-Score:3.97|P-value:4.10E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-4.68|P-value:1.44E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.39|P-value:3.49E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.94|P-value:4.67E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.38|P-value:3.52E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.12|P-value:9.74E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.17|P-value:7.61E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.24|P-value:6.62E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.37|P-value:3.67E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.20|P-value:1.54E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.91|P-value:5.21E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.22|P-value:6.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.13|P-value:9.52E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.63|P-value:1.41E-4 ID:SGTC_3106|Compound:9121286|FD-Score:5.93|P-value:1.92E-9 ID:SGTC_3127|Compound:9126946|FD-Score:3.90|P-value:5.38E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.12|P-value:9.87E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.13|P-value:9.39E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.34|P-value:4.11E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.13|P-value:9.43E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.22|P-value:1.22E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.37|P-value:4.08E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.09|P-value:2.45E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.02|P-value:3.34E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.65|P-value:1.47E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.24|P-value:6.60E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.10|P-value:9.51E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.43|P-value:5.41E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.10|P-value:9.40E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.92|P-value:4.99E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.35|P-value:4.47E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.35|P-value:5.36E-8 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.42|P-value:3.58E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.02|P-value:3.27E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.99|P-value:3.31E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.31|P-value:5.11E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.41|P-value:3.14E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.24|P-value:6.46E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.13|P-value:1.81E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.92|P-value:4.95E-5 ID:SGTC_1921|Compound:5740136|FD-Score:3.97|P-value:4.10E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-4.68|P-value:1.44E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.39|P-value:3.49E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.94|P-value:4.67E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.38|P-value:3.52E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.12|P-value:9.74E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.17|P-value:7.61E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.24|P-value:6.62E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.37|P-value:3.67E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.20|P-value:1.54E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.91|P-value:5.21E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.22|P-value:6.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.13|P-value:9.52E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.63|P-value:1.41E-4 ID:SGTC_3106|Compound:9121286|FD-Score:5.93|P-value:1.92E-9 ID:SGTC_3127|Compound:9126946|FD-Score:3.90|P-value:5.38E-5 ID:SGTC_3224|Compound:9130643|FD-Score:3.12|P-value:9.87E-4

Top fitness defect scores for YNL109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3106 9121286 5.93 49.5 µM 1.92E-9 2 1.55E-9
2 SGTC_1468 k284-1086 5.42 134.0 µM 3.58E-8 DNA intercalators 8 2.97E-8
3 SGTC_1132 3456-3614 5.35 2.5 µM 5.36E-8 tubulin folding & SWR complex 14 4.47E-8
4 SGTC_915 methyl methanesulfonate (MMS) 4.43 110.0 mM 5.41E-6 DNA damage response 30 4.72E-6
5 SGTC_2567 aureobasidin a 4.20 60.0 nM 1.54E-5 84 1.35E-5
6 SGTC_530 4358-1714 4.09 28.0 µM 2.45E-5 41 2.17E-5
7 SGTC_1475 4092-1048 4.02 11.7 µM 3.27E-5 plasma membrane duress 29 2.90E-5
8 SGTC_610 4215-0184 4.02 155.0 µM 3.34E-5 exosome 11 2.96E-5
9 SGTC_1921 5740136 3.97 50.0 µM 4.10E-5 TRP & mitochondrial translation 58 3.64E-5
10 SGTC_1935 st074532 3.94 41.6 µM 4.67E-5 33 4.15E-5
11 SGTC_1910 st062352 3.92 60.4 µM 4.95E-5 39 4.40E-5
12 SGTC_992 3909-8734 3.92 162.0 µM 4.99E-5 22 4.44E-5
13 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.91 100.0 µM 5.21E-5 35 4.64E-5
14 SGTC_3127 9126946 3.90 49.5 µM 5.38E-5 ERG2 18 4.79E-5
15 SGTC_2688 kanamycin b 3.72 96.7 µM 1.12E-4 calcium & mitochondrial duress 403 1.00E-4
16 SGTC_760 0568-0725 3.65 82.9 µM 1.47E-4 16 1.32E-4
17 SGTC_517 1365-0151 3.37 113.0 µM 4.08E-4 51 3.71E-4
18 SGTC_1129 3453-1384 3.35 223.0 µM 4.47E-4 68 4.06E-4
19 SGTC_163 1327-0036 3.34 7.5 µM 4.57E-4 155 4.16E-4
20 SGTC_1671 st016596 3.31 74.5 µM 5.11E-4 30 4.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.36E-18 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.151 1.54E-18 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.126 2.89E-13 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.120 3.20E-12 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.116 1.87E-11 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.107 4.57E-10 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.105 1.11E-9 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.105 1.20E-9 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.103 1.84E-9 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.101 4.89E-9 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.100 5.62E-9 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.100 6.91E-9 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.099 8.73E-9 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.096 2.84E-8 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.095 3.20E-8 YJL027C_p YJL027C_p hom Putative protein of unknown function