YNL110C / NOP15

Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL110C / NOP15

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.84|P-value:9.32E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:9.15|P-value:4.70E-14 ID:SGTC_108|Compound:0509-0257|FD-Score:4.85|P-value:4.04E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.01|P-value:2.40E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.65|P-value:2.20E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.96|P-value:2.83E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.28|P-value:9.08E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:4.09|P-value:4.54E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.55|P-value:1.11E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.17|P-value:3.56E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:4.58|P-value:1.01E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.96|P-value:2.81E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.37|P-value:1.97E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.32|P-value:2.28E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.99|P-value:5.36E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:5.49|P-value:4.04E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:3.85|P-value:8.86E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.75|P-value:5.84E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:7.02|P-value:5.79E-9 ID:SGTC_944|Compound:3370-0224|FD-Score:3.96|P-value:6.54E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.97|P-value:2.73E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.61|P-value:9.20E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.22|P-value:3.10E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:5.34|P-value:7.17E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.70|P-value:1.80E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:5.75|P-value:1.50E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:5.00|P-value:2.46E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:10.40|P-value:1.21E-17 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.82|P-value:3.93E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.94|P-value:6.17E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.94|P-value:3.06E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:5.04|P-value:2.16E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:6.73|P-value:2.23E-8 ID:SGTC_1673|Compound:st016611|FD-Score:-5.70|P-value:1.53E-6 ID:SGTC_1769|Compound:st044406|FD-Score:5.30|P-value:8.40E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.08|P-value:4.05E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.78|P-value:9.47E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-5.20|P-value:1.02E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-5.12|P-value:1.37E-5 ID:SGTC_2323|Compound:6148992|FD-Score:6.96|P-value:7.74E-9 ID:SGTC_2327|Compound:6189656|FD-Score:4.19|P-value:3.34E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.89|P-value:7.01E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.95|P-value:6.73E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:6.21|P-value:2.24E-7 ID:SGTC_2785|Compound:7756463|FD-Score:4.85|P-value:4.16E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.33|P-value:1.32E-7 ID:SGTC_2801|Compound:7907800|FD-Score:7.02|P-value:5.72E-9 ID:SGTC_2858|Compound:9025781|FD-Score:4.55|P-value:1.10E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.27|P-value:7.86E-6 ID:SGTC_2991|Compound:9074669|FD-Score:-3.84|P-value:8.16E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-4.36|P-value:1.77E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-4.52|P-value:1.05E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-5.20|P-value:1.01E-5 ID:SGTC_3312|Compound:9133330|FD-Score:4.32|P-value:2.26E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-4.19|P-value:2.95E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.84|P-value:9.32E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:9.15|P-value:4.70E-14 ID:SGTC_108|Compound:0509-0257|FD-Score:4.85|P-value:4.04E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.01|P-value:2.40E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.65|P-value:2.20E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.96|P-value:2.83E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.28|P-value:9.08E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:4.09|P-value:4.54E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.55|P-value:1.11E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.17|P-value:3.56E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:4.58|P-value:1.01E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.96|P-value:2.81E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.37|P-value:1.97E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.32|P-value:2.28E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.99|P-value:5.36E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:5.49|P-value:4.04E-6 ID:SGTC_830|Compound:4076-0286|FD-Score:3.85|P-value:8.86E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.75|P-value:5.84E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:7.02|P-value:5.79E-9 ID:SGTC_944|Compound:3370-0224|FD-Score:3.96|P-value:6.54E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.97|P-value:2.73E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.61|P-value:9.20E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.22|P-value:3.10E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:5.34|P-value:7.17E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.70|P-value:1.80E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:5.75|P-value:1.50E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:5.00|P-value:2.46E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:10.40|P-value:1.21E-17 ID:SGTC_1405|Compound:3909-7894|FD-Score:-4.82|P-value:3.93E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.94|P-value:6.17E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.94|P-value:3.06E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:5.04|P-value:2.16E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:6.73|P-value:2.23E-8 ID:SGTC_1673|Compound:st016611|FD-Score:-5.70|P-value:1.53E-6 ID:SGTC_1769|Compound:st044406|FD-Score:5.30|P-value:8.40E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.08|P-value:4.05E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.78|P-value:9.47E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-5.20|P-value:1.02E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-5.12|P-value:1.37E-5 ID:SGTC_2323|Compound:6148992|FD-Score:6.96|P-value:7.74E-9 ID:SGTC_2327|Compound:6189656|FD-Score:4.19|P-value:3.34E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.89|P-value:7.01E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.95|P-value:6.73E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:6.21|P-value:2.24E-7 ID:SGTC_2785|Compound:7756463|FD-Score:4.85|P-value:4.16E-5 ID:SGTC_2788|Compound:5282734|FD-Score:6.33|P-value:1.32E-7 ID:SGTC_2801|Compound:7907800|FD-Score:7.02|P-value:5.72E-9 ID:SGTC_2858|Compound:9025781|FD-Score:4.55|P-value:1.10E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.27|P-value:7.86E-6 ID:SGTC_2991|Compound:9074669|FD-Score:-3.84|P-value:8.16E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-4.36|P-value:1.77E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-4.52|P-value:1.05E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-5.20|P-value:1.01E-5 ID:SGTC_3312|Compound:9133330|FD-Score:4.32|P-value:2.26E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-4.19|P-value:2.95E-4

Top fitness defect scores for YNL110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1154 4088-0362 10.40 150.0 µM 1.21E-17 1 1.15E-25 4.83
2 SGTC_104 0074-0074 9.15 591.0 µM 4.70E-14 1 2.75E-20 2.12
3 SGTC_2801 7907800 7.02 81.8 µM 5.72E-9 1 1.11E-12 0.98
4 SGTC_927 2425-1185 7.02 123.0 µM 5.79E-9 1 1.13E-12 2.20
5 SGTC_2323 6148992 6.96 148.3 µM 7.74E-9 4 1.75E-12 0.27
6 SGTC_1469 k284-2957 6.73 126.0 µM 2.23E-8 2 8.46E-12 0.77
7 SGTC_2788 5282734 6.33 71.4 µM 1.32E-7 1 1.20E-10 1.48
8 SGTC_2497 7-hydroxyflavone 6.21 100.0 µM 2.24E-7 1 2.65E-10 0.83
9 SGTC_1124 fisetin 5.75 1.2 µM 1.50E-6 5 4.50E-9 0.88
10 SGTC_1077 5-fluorocytosine 5.70 377.0 nM 1.80E-6 exosome 11 5.91E-9 0.16
11 SGTC_118 0083-0097 5.65 135.3 µM 2.20E-6 translation 5 7.96E-9 0.11
12 SGTC_782 0083-0095 5.49 30.5 µM 4.04E-6 2 1.97E-8 1.10
13 SGTC_1074 carmofur 5.34 3.8 µM 7.17E-6 exosome 18 4.62E-8 0.07
14 SGTC_1769 st044406 5.30 64.4 µM 8.40E-6 2 5.84E-8 0.71
15 SGTC_273 hydroxyurea 5.28 18.1 mM 9.08E-6 heme biosynthesis & mitochondrial translocase 9 6.55E-8 0.12
16 SGTC_1466 k213-0079 5.04 57.5 µM 2.16E-5 3 2.37E-7 0.46
17 SGTC_115 0527-0192 5.01 112.0 µM 2.40E-5 10 2.77E-7 0.14
18 SGTC_1153 4055-0057 5.00 267.0 µM 2.46E-5 2 2.89E-7 0.34
19 SGTC_957 1187-1561 4.97 14.1 µM 2.73E-5 4 3.36E-7 0.55
20 SGTC_610 4215-0184 4.96 155.0 µM 2.81E-5 exosome 17 3.51E-7 0.37

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 3.66E-30 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.188 6.46E-28 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.180 1.10E-25 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.178 4.16E-25 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.158 4.31E-20 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.156 9.54E-20 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.153 4.29E-19 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.145 3.16E-17 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.144 4.70E-17 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.141 1.84E-16 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.136 3.15E-15 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.130 4.13E-14 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.130 5.05E-14 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.127 1.39E-13 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.127 1.86E-13 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication