YNL112W / DBP2

ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL112W / DBP2

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:8.28|P-value:3.20E-13 ID:SGTC_8|Compound:0354-0001|FD-Score:6.08|P-value:6.37E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:9.21|P-value:5.93E-16 ID:SGTC_97|Compound:0535-0701|FD-Score:3.91|P-value:3.35E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.78|P-value:1.62E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:6.01|P-value:8.94E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:4.25|P-value:1.11E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.70|P-value:6.48E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.79|P-value:2.48E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:3.59|P-value:9.18E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:11.10|P-value:1.88E-22 ID:SGTC_187|Compound:1488-2104|FD-Score:-4.06|P-value:2.10E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.30|P-value:2.05E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.43|P-value:5.92E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:5.23|P-value:2.75E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:6.91|P-value:9.37E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:4.77|P-value:1.67E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:6.63|P-value:4.26E-9 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.83|P-value:1.36E-5 ID:SGTC_263|Compound:alizarin|FD-Score:-4.53|P-value:4.15E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.96|P-value:8.06E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.73|P-value:3.13E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:6.19|P-value:3.75E-8 ID:SGTC_316|Compound:k060-0003|FD-Score:3.85|P-value:4.13E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.54|P-value:3.98E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.60|P-value:3.23E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.86|P-value:3.93E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.32|P-value:1.88E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.12|P-value:1.74E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.75|P-value:1.84E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.53|P-value:4.07E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.72|P-value:6.12E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.95|P-value:1.18E-7 ID:SGTC_611|Compound:3453-1652|FD-Score:6.97|P-value:6.92E-10 ID:SGTC_639|Compound:0833-0042|FD-Score:4.26|P-value:1.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.41|P-value:1.27E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:5.61|P-value:5.49E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:5.01|P-value:6.68E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:4.62|P-value:3.02E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.73|P-value:5.96E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:7.20|P-value:1.95E-10 ID:SGTC_842|Compound:0271-0008|FD-Score:4.21|P-value:1.28E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:8.74|P-value:1.49E-14 ID:SGTC_897|Compound:1000-0139|FD-Score:3.61|P-value:8.49E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.91|P-value:9.85E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:3.59|P-value:9.12E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.71|P-value:6.33E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:7.01|P-value:5.49E-10 ID:SGTC_961|Compound:1252-1571|FD-Score:3.67|P-value:7.09E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.67|P-value:2.47E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.62|P-value:8.18E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.38|P-value:1.46E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:8.01|P-value:1.71E-12 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.20|P-value:1.29E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.76|P-value:1.79E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.86|P-value:1.20E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.58|P-value:9.36E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:9.92|P-value:3.32E-18 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.48|P-value:4.88E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.44|P-value:5.62E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.34|P-value:7.99E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.33|P-value:8.37E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.56|P-value:6.67E-7 ID:SGTC_1647|Compound:st011722|FD-Score:4.60|P-value:3.15E-5 ID:SGTC_1660|Compound:st012960|FD-Score:4.32|P-value:8.73E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.99|P-value:2.60E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.37|P-value:7.21E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.66|P-value:7.46E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.76|P-value:2.81E-7 ID:SGTC_1846|Compound:st056244|FD-Score:-3.62|P-value:8.38E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.83|P-value:1.46E-9 ID:SGTC_1962|Compound:st076595|FD-Score:5.91|P-value:1.38E-7 ID:SGTC_1967|Compound:st070177|FD-Score:-3.80|P-value:4.76E-4 ID:SGTC_2004|Compound:4023728|FD-Score:13.70|P-value:3.51E-33 ID:SGTC_2016|Compound:5121758|FD-Score:3.80|P-value:4.74E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.76|P-value:1.77E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.61|P-value:8.52E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.03|P-value:2.33E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.49|P-value:4.83E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.92|P-value:3.27E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.03|P-value:6.25E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.77|P-value:5.35E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.16|P-value:1.51E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.27|P-value:1.03E-4 ID:SGTC_2451|Compound:5856223|FD-Score:5.06|P-value:5.50E-6 ID:SGTC_2466|Compound:5983409|FD-Score:4.34|P-value:8.16E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.76|P-value:5.44E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.11|P-value:1.80E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.88|P-value:1.61E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:5.87|P-value:1.70E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.59|P-value:8.90E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-6.89|P-value:1.05E-9 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.52|P-value:7.21E-9 ID:SGTC_2760|Compound:etidronate|FD-Score:3.57|P-value:9.75E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.15|P-value:1.58E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.39|P-value:1.42E-6 ID:SGTC_2804|Compound:7954240|FD-Score:-4.86|P-value:1.20E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.77|P-value:5.29E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-3.57|P-value:9.54E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.56|P-value:3.66E-5 ID:SGTC_2930|Compound:9013230|FD-Score:6.81|P-value:1.67E-9 ID:SGTC_2958|Compound:9077254|FD-Score:3.81|P-value:4.63E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.81|P-value:4.64E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.12|P-value:1.70E-4 ID:SGTC_3141|Compound:9094609|FD-Score:6.71|P-value:2.73E-9 ID:SGTC_3142|Compound:9086498|FD-Score:8.69|P-value:2.11E-14 ID:SGTC_3161|Compound:9100388|FD-Score:6.16|P-value:4.38E-8 ID:SGTC_3175|Compound:9106517|FD-Score:5.49|P-value:9.10E-7 ID:SGTC_3181|Compound:9108277|FD-Score:4.52|P-value:4.25E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.53|P-value:7.84E-7 ID:SGTC_3201|Compound:9113999|FD-Score:-3.84|P-value:4.22E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.13|P-value:1.65E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.68|P-value:6.84E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:8.28|P-value:3.20E-13 ID:SGTC_8|Compound:0354-0001|FD-Score:6.08|P-value:6.37E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:9.21|P-value:5.93E-16 ID:SGTC_97|Compound:0535-0701|FD-Score:3.91|P-value:3.35E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:4.78|P-value:1.62E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:6.01|P-value:8.94E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:4.25|P-value:1.11E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.70|P-value:6.48E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.79|P-value:2.48E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:3.59|P-value:9.18E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:11.10|P-value:1.88E-22 ID:SGTC_187|Compound:1488-2104|FD-Score:-4.06|P-value:2.10E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.30|P-value:2.05E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.43|P-value:5.92E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:5.23|P-value:2.75E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:6.91|P-value:9.37E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:4.77|P-value:1.67E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:6.63|P-value:4.26E-9 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.83|P-value:1.36E-5 ID:SGTC_263|Compound:alizarin|FD-Score:-4.53|P-value:4.15E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.96|P-value:8.06E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.73|P-value:3.13E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:6.19|P-value:3.75E-8 ID:SGTC_316|Compound:k060-0003|FD-Score:3.85|P-value:4.13E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.54|P-value:3.98E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.60|P-value:3.23E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.86|P-value:3.93E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:5.32|P-value:1.88E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.12|P-value:1.74E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.75|P-value:1.84E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.53|P-value:4.07E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.72|P-value:6.12E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.95|P-value:1.18E-7 ID:SGTC_611|Compound:3453-1652|FD-Score:6.97|P-value:6.92E-10 ID:SGTC_639|Compound:0833-0042|FD-Score:4.26|P-value:1.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.41|P-value:1.27E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:5.61|P-value:5.49E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:5.01|P-value:6.68E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:4.62|P-value:3.02E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.73|P-value:5.96E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:7.20|P-value:1.95E-10 ID:SGTC_842|Compound:0271-0008|FD-Score:4.21|P-value:1.28E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:8.74|P-value:1.49E-14 ID:SGTC_897|Compound:1000-0139|FD-Score:3.61|P-value:8.49E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.91|P-value:9.85E-6 ID:SGTC_926|Compound:2268-1401|FD-Score:3.59|P-value:9.12E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.71|P-value:6.33E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:7.01|P-value:5.49E-10 ID:SGTC_961|Compound:1252-1571|FD-Score:3.67|P-value:7.09E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.67|P-value:2.47E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.62|P-value:8.18E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.38|P-value:1.46E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:8.01|P-value:1.71E-12 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.20|P-value:1.29E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.76|P-value:1.79E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.86|P-value:1.20E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.58|P-value:9.36E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:9.92|P-value:3.32E-18 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.48|P-value:4.88E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.44|P-value:5.62E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.34|P-value:7.99E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.33|P-value:8.37E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.56|P-value:6.67E-7 ID:SGTC_1647|Compound:st011722|FD-Score:4.60|P-value:3.15E-5 ID:SGTC_1660|Compound:st012960|FD-Score:4.32|P-value:8.73E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.99|P-value:2.60E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.37|P-value:7.21E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.66|P-value:7.46E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.76|P-value:2.81E-7 ID:SGTC_1846|Compound:st056244|FD-Score:-3.62|P-value:8.38E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.83|P-value:1.46E-9 ID:SGTC_1962|Compound:st076595|FD-Score:5.91|P-value:1.38E-7 ID:SGTC_1967|Compound:st070177|FD-Score:-3.80|P-value:4.76E-4 ID:SGTC_2004|Compound:4023728|FD-Score:13.70|P-value:3.51E-33 ID:SGTC_2016|Compound:5121758|FD-Score:3.80|P-value:4.74E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.76|P-value:1.77E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.61|P-value:8.52E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.03|P-value:2.33E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.49|P-value:4.83E-5 ID:SGTC_2172|Compound:5754775|FD-Score:3.92|P-value:3.27E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.03|P-value:6.25E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.77|P-value:5.35E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.16|P-value:1.51E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.27|P-value:1.03E-4 ID:SGTC_2451|Compound:5856223|FD-Score:5.06|P-value:5.50E-6 ID:SGTC_2466|Compound:5983409|FD-Score:4.34|P-value:8.16E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.76|P-value:5.44E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.11|P-value:1.80E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.88|P-value:1.61E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:5.87|P-value:1.70E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.59|P-value:8.90E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-6.89|P-value:1.05E-9 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.52|P-value:7.21E-9 ID:SGTC_2760|Compound:etidronate|FD-Score:3.57|P-value:9.75E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.15|P-value:1.58E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.39|P-value:1.42E-6 ID:SGTC_2804|Compound:7954240|FD-Score:-4.86|P-value:1.20E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.77|P-value:5.29E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-3.57|P-value:9.54E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.56|P-value:3.66E-5 ID:SGTC_2930|Compound:9013230|FD-Score:6.81|P-value:1.67E-9 ID:SGTC_2958|Compound:9077254|FD-Score:3.81|P-value:4.63E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.81|P-value:4.64E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.12|P-value:1.70E-4 ID:SGTC_3141|Compound:9094609|FD-Score:6.71|P-value:2.73E-9 ID:SGTC_3142|Compound:9086498|FD-Score:8.69|P-value:2.11E-14 ID:SGTC_3161|Compound:9100388|FD-Score:6.16|P-value:4.38E-8 ID:SGTC_3175|Compound:9106517|FD-Score:5.49|P-value:9.10E-7 ID:SGTC_3181|Compound:9108277|FD-Score:4.52|P-value:4.25E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.53|P-value:7.84E-7 ID:SGTC_3201|Compound:9113999|FD-Score:-3.84|P-value:4.22E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.13|P-value:1.65E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.68|P-value:6.84E-4

Top fitness defect scores for YNL112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2004 4023728 13.70 41.9 µM 3.51E-33 3 2.79E-43 0.94
2 SGTC_184 1494-0393 11.10 24.7 µM 1.88E-22 3 4.18E-29 3.26
3 SGTC_1310 1188-0297 9.92 994.0 nM 3.32E-18 azole & statin 1 1.70E-23 2.63
4 SGTC_81 0411-0046 9.21 10.0 µM 5.93E-16 8 1.59E-20 0.04
5 SGTC_851 0394-0702 8.74 453.0 µM 1.49E-14 mitochondrial processes 3 1.12E-18 1.62
6 SGTC_3142 9086498 8.69 49.5 µM 2.11E-14 iron homeostasis 11 1.77E-18 0.09
7 SGTC_1 0258-0098 8.28 57.4 µM 3.20E-13 heme biosynthesis & mitochondrial translocase 3 6.38E-17 1.83
8 SGTC_1113 artemisinin 8.01 1.2 µM 1.71E-12 heme biosynthesis & mitochondrial translocase 9 5.81E-16 0.54
9 SGTC_833 3852-0053 7.20 558.0 µM 1.95E-10 1 2.99E-13 1.79
10 SGTC_953 1188-0045 7.01 9.7 µM 5.49E-10 60S ribosome export 2 1.16E-12 0.09
11 SGTC_611 3453-1652 6.97 23.7 µM 6.92E-10 5 1.58E-12 0.07
12 SGTC_212 3807-4682 6.91 38.8 µM 9.37E-10 tubulin folding & SWR complex 10 2.35E-12 0.12
13 SGTC_1959 st077091 6.83 55.8 µM 1.46E-9 RPP1 & pyrimidine depletion 9 4.24E-12 0.02
14 SGTC_2930 9013230 6.81 14.9 µM 1.67E-9 heme biosynthesis & mitochondrial translocase 10 5.03E-12 0.38
15 SGTC_3141 9094609 6.71 49.5 µM 2.73E-9 iron homeostasis 5 9.62E-12 0.58
16 SGTC_217 ketoconazole 6.63 989.0 nM 4.26E-9 ergosterol depletion effects on membrane 4 1.73E-11 0.09
17 SGTC_2759 disulfiram 6.52 3.4 µM 7.21E-9 6 3.45E-11 0.22
18 SGTC_309 k408-0051 6.19 1.5 µM 3.75E-8 8 3.01E-10 0.07
19 SGTC_3161 9100388 6.16 49.5 µM 4.38E-8 iron homeostasis 4 3.69E-10 1.76
20 SGTC_8 0354-0001 6.08 70.0 µM 6.37E-8 2 6.05E-10 0.54

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.303 4.16E-72 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.291 2.74E-66 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.289 1.05E-65 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.289 1.75E-65 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.238 2.56E-44 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.225 9.60E-40 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.217 5.39E-37 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.216 1.07E-36 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.211 5.02E-35 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.193 2.51E-29 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.183 1.15E-26 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.178 2.38E-25 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.175 2.42E-24 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.150 2.84E-18 YER112W LSM4 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
0.143 9.42E-17 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein