YNL113W / RPC19

RNA polymerase subunit AC19, common to RNA polymerases I and III

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL113W / RPC19

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.47|P-value:7.14E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-4.40|P-value:2.24E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.42|P-value:2.35E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.47|P-value:1.94E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.85|P-value:1.73E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.79|P-value:5.08E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.50|P-value:5.71E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:5.60|P-value:1.21E-7 ID:SGTC_533|Compound:1222-0222|FD-Score:4.50|P-value:1.71E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.23|P-value:4.96E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.64|P-value:8.22E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:3.91|P-value:1.59E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.55|P-value:5.38E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.59|P-value:4.72E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.25|P-value:4.56E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.04|P-value:8.89E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.74|P-value:2.55E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:5.71|P-value:7.01E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.61|P-value:4.51E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.16|P-value:6.42E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.72|P-value:3.10E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.59|P-value:4.73E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.57|P-value:5.12E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:6.25|P-value:4.21E-9 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.61|P-value:4.43E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:5.30|P-value:5.13E-7 ID:SGTC_1588|Compound:farnesol|FD-Score:3.62|P-value:4.29E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.19|P-value:4.95E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.43|P-value:2.24E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.70|P-value:3.33E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.39|P-value:8.97E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.38|P-value:2.72E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.36|P-value:9.95E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.68|P-value:3.54E-4 ID:SGTC_1864|Compound:st057645|FD-Score:4.10|P-value:8.04E-5 ID:SGTC_1942|Compound:st076330|FD-Score:5.12|P-value:1.19E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.89|P-value:1.70E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.40|P-value:2.18E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:3.66|P-value:3.74E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.46|P-value:1.96E-5 ID:SGTC_2273|Compound:7815444|FD-Score:4.19|P-value:5.69E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.38|P-value:9.26E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.03|P-value:9.26E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.49|P-value:1.76E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.57|P-value:4.60E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.06|P-value:9.19E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.36|P-value:9.08E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.50|P-value:6.43E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-3.34|P-value:9.53E-4 ID:SGTC_2908|Compound:7930301|FD-Score:5.08|P-value:1.43E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-3.47|P-value:6.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.70|P-value:3.35E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-4.32|P-value:2.98E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.47|P-value:7.14E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-4.40|P-value:2.24E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.42|P-value:2.35E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.47|P-value:1.94E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.85|P-value:1.73E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.79|P-value:5.08E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.50|P-value:5.71E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:5.60|P-value:1.21E-7 ID:SGTC_533|Compound:1222-0222|FD-Score:4.50|P-value:1.71E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.23|P-value:4.96E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.64|P-value:8.22E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:3.91|P-value:1.59E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.55|P-value:5.38E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.59|P-value:4.72E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.25|P-value:4.56E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.04|P-value:8.89E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.74|P-value:2.55E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:5.71|P-value:7.01E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.61|P-value:4.51E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.16|P-value:6.42E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.72|P-value:3.10E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.59|P-value:4.73E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.57|P-value:5.12E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:6.25|P-value:4.21E-9 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.61|P-value:4.43E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:5.30|P-value:5.13E-7 ID:SGTC_1588|Compound:farnesol|FD-Score:3.62|P-value:4.29E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.19|P-value:4.95E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.43|P-value:2.24E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.70|P-value:3.33E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.39|P-value:8.97E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.38|P-value:2.72E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.36|P-value:9.95E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.68|P-value:3.54E-4 ID:SGTC_1864|Compound:st057645|FD-Score:4.10|P-value:8.04E-5 ID:SGTC_1942|Compound:st076330|FD-Score:5.12|P-value:1.19E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.89|P-value:1.70E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.40|P-value:2.18E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:3.66|P-value:3.74E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.46|P-value:1.96E-5 ID:SGTC_2273|Compound:7815444|FD-Score:4.19|P-value:5.69E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.38|P-value:9.26E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.03|P-value:9.26E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.49|P-value:1.76E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.57|P-value:4.60E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.06|P-value:9.19E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.36|P-value:9.08E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.50|P-value:6.43E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-3.34|P-value:9.53E-4 ID:SGTC_2908|Compound:7930301|FD-Score:5.08|P-value:1.43E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-3.47|P-value:6.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.70|P-value:3.35E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-4.32|P-value:2.98E-5

Top fitness defect scores for YNL113W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1473 k844-0725 6.25 134.0 µM 4.21E-9 1 2.08E-10 0.99
2 SGTC_1023 4482-3888 5.71 16.0 µM 7.01E-8 TSC3-RPN4 4 5.56E-9 0.95
3 SGTC_518 1021-0119 5.60 62.6 µM 1.21E-7 ERG2 2 1.05E-8 0.10
4 SGTC_1532 4',5'-dihydroxyflavone 5.30 78.7 µM 5.13E-7 Golgi 1 5.69E-8 0.58
5 SGTC_1942 st076330 5.12 65.2 µM 1.19E-6 3 1.51E-7 0.70
6 SGTC_2908 7930301 5.08 100.0 µM 1.43E-6 1 1.88E-7 0.69
7 SGTC_445 e6 berbamine 4.79 66.0 µM 5.08E-6 NEO1-PIK1 22 8.26E-7 0.35
8 SGTC_533 1222-0222 4.50 6.7 µM 1.71E-5 PDR1 7 3.40E-6 2.48E-4
9 SGTC_2526 patulin 4.49 37.6 µM 1.76E-5 8 3.53E-6 0.02
10 SGTC_245 methotrexate 4.47 289.6 µM 1.94E-5 10 3.94E-6 0.01
11 SGTC_2265 7929201 4.46 200.0 µM 1.96E-5 4 4.00E-6 0.12
12 SGTC_1631 benzylvanillin 4.43 81.9 µM 2.24E-5 Golgi 3 4.67E-6 0.08
13 SGTC_93 0109-0045 4.42 59.2 µM 2.35E-5 DNA damage response 17 4.94E-6 0.00
14 SGTC_1752 st044819 4.38 83.0 µM 2.72E-5 6 5.85E-6 0.36
15 SGTC_708 3448-5400 4.25 146.0 µM 4.56E-5 14 1.07E-5 0.04
16 SGTC_534 k292-0788 4.23 63.4 µM 4.96E-5 mitochondrial processes 8 1.18E-5 0.02
17 SGTC_2273 7815444 4.19 169.1 µM 5.69E-5 2 1.38E-5 0.30
18 SGTC_1230 0170-0365 4.16 3.8 µM 6.42E-5 endomembrane recycling 21 1.59E-5 0.06
19 SGTC_1864 st057645 4.10 30.4 µM 8.04E-5 amide catabolism 2 2.07E-5 0.23
20 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.06 100.0 µM 9.19E-5 10 2.42E-5 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.80E-9 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.102 2.98E-9 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.097 2.17E-8 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.094 5.13E-8 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.089 2.52E-7 YOR210W RPB10 het RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
0.086 5.33E-7 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.086 6.84E-7 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.081 2.43E-6 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.079 4.11E-6 YLR198C_d YLR198C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
0.078 6.64E-6 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.077 8.10E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.076 9.38E-6 YGR168C_p YGR168C_p hom Putative protein of unknown function; YGR168C is not an essential gene
0.076 1.04E-5 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.075 1.25E-5 YPL178W CBC2 hom Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
0.075 1.30E-5 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast