YNL114C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL114C / YNL114C

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:4.47|P-value:5.75E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:4.48|P-value:5.49E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:3.62|P-value:9.03E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:9.18|P-value:9.74E-16 ID:SGTC_104|Compound:0074-0074|FD-Score:3.91|P-value:3.72E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.72|P-value:3.91E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:4.78|P-value:1.83E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.69|P-value:2.18E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.77|P-value:5.04E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.48|P-value:5.48E-5 ID:SGTC_263|Compound:alizarin|FD-Score:-4.75|P-value:1.72E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.71|P-value:2.37E-14 ID:SGTC_302|Compound:1094-0063|FD-Score:6.21|P-value:3.90E-8 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.70|P-value:6.10E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:6.34|P-value:2.15E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.15|P-value:1.45E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.93|P-value:3.52E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.28|P-value:1.10E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.80|P-value:1.40E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:3.67|P-value:7.83E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.68|P-value:6.47E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-4.32|P-value:8.21E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.74|P-value:6.36E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.19|P-value:1.50E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.29|P-value:1.07E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-5.62|P-value:4.91E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.92|P-value:3.08E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:7.64|P-value:1.92E-11 ID:SGTC_900|Compound:1112-0045|FD-Score:3.73|P-value:6.41E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-11.00|P-value:4.63E-22 ID:SGTC_933|Compound:2914-0560|FD-Score:3.77|P-value:5.81E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.91|P-value:3.75E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.63|P-value:8.79E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.79|P-value:4.73E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.94|P-value:2.89E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.59|P-value:9.72E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.89|P-value:1.27E-9 ID:SGTC_1313|Compound:1220-0047|FD-Score:-5.17|P-value:3.32E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.96|P-value:3.18E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-5.38|P-value:1.34E-6 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-4.03|P-value:2.18E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.76|P-value:5.86E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.99|P-value:2.86E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.78|P-value:5.49E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.66|P-value:8.02E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-3.61|P-value:8.12E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.97|P-value:3.07E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.18|P-value:1.54E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.94|P-value:3.43E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.72|P-value:2.26E-5 ID:SGTC_2004|Compound:4023728|FD-Score:8.26|P-value:4.45E-13 ID:SGTC_2164|Compound:5685496|FD-Score:-3.67|P-value:6.77E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.24|P-value:1.28E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.53|P-value:4.67E-5 ID:SGTC_2339|Compound:9000433|FD-Score:5.65|P-value:5.27E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.07|P-value:5.96E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:4.91|P-value:1.12E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.67|P-value:7.78E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.44|P-value:6.43E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.94|P-value:3.38E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.83|P-value:1.28E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.97|P-value:3.04E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.92|P-value:3.12E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.81|P-value:5.03E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.97|P-value:3.05E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.10|P-value:1.99E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:4.47|P-value:5.75E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:4.48|P-value:5.49E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:3.62|P-value:9.03E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:9.18|P-value:9.74E-16 ID:SGTC_104|Compound:0074-0074|FD-Score:3.91|P-value:3.72E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.72|P-value:3.91E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:4.78|P-value:1.83E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.69|P-value:2.18E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.77|P-value:5.04E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.48|P-value:5.48E-5 ID:SGTC_263|Compound:alizarin|FD-Score:-4.75|P-value:1.72E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.71|P-value:2.37E-14 ID:SGTC_302|Compound:1094-0063|FD-Score:6.21|P-value:3.90E-8 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.70|P-value:6.10E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:6.34|P-value:2.15E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.15|P-value:1.45E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.93|P-value:3.52E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.28|P-value:1.10E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.80|P-value:1.40E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:3.67|P-value:7.83E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.68|P-value:6.47E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-4.32|P-value:8.21E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.74|P-value:6.36E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.19|P-value:1.50E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.29|P-value:1.07E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-5.62|P-value:4.91E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.92|P-value:3.08E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:7.64|P-value:1.92E-11 ID:SGTC_900|Compound:1112-0045|FD-Score:3.73|P-value:6.41E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-11.00|P-value:4.63E-22 ID:SGTC_933|Compound:2914-0560|FD-Score:3.77|P-value:5.81E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.91|P-value:3.75E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.63|P-value:8.79E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.79|P-value:4.73E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.94|P-value:2.89E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.59|P-value:9.72E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.89|P-value:1.27E-9 ID:SGTC_1313|Compound:1220-0047|FD-Score:-5.17|P-value:3.32E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.96|P-value:3.18E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:-5.38|P-value:1.34E-6 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-4.03|P-value:2.18E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.76|P-value:5.86E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.99|P-value:2.86E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.78|P-value:5.49E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.66|P-value:8.02E-4 ID:SGTC_1817|Compound:st052116|FD-Score:-3.61|P-value:8.12E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.97|P-value:3.07E-4 ID:SGTC_1922|Compound:5578187|FD-Score:4.18|P-value:1.54E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.94|P-value:3.43E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.72|P-value:2.26E-5 ID:SGTC_2004|Compound:4023728|FD-Score:8.26|P-value:4.45E-13 ID:SGTC_2164|Compound:5685496|FD-Score:-3.67|P-value:6.77E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.24|P-value:1.28E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.53|P-value:4.67E-5 ID:SGTC_2339|Compound:9000433|FD-Score:5.65|P-value:5.27E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.07|P-value:5.96E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:4.91|P-value:1.12E-5 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.67|P-value:7.78E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.44|P-value:6.43E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.94|P-value:3.38E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.83|P-value:1.28E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.97|P-value:3.04E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.92|P-value:3.12E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.81|P-value:5.03E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.97|P-value:3.05E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.10|P-value:1.99E-4

Top fitness defect scores for YNL114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_81 0411-0046 9.18 10.0 µM 9.74E-16 9 2.21E-20 0.22
2 SGTC_273 hydroxyurea 8.71 18.1 mM 2.37E-14 heme biosynthesis & mitochondrial translocase 2 1.52E-18 1.10
3 SGTC_2004 4023728 8.26 41.9 µM 4.45E-13 11 7.41E-17 1.13
4 SGTC_897 1000-0139 7.64 31.4 µM 1.92E-11 3 1.09E-14 1.33
5 SGTC_1310 1188-0297 6.89 994.0 nM 1.27E-9 azole & statin 4 2.79E-12 0.14
6 SGTC_309 k408-0051 6.34 1.5 µM 2.15E-8 7 1.18E-10 0.15
7 SGTC_302 1094-0063 6.21 18.9 µM 3.90E-8 3 2.60E-10 0.57
8 SGTC_108 0509-0257 5.72 621.1 µM 3.91E-7 7 5.47E-9 0.23
9 SGTC_2339 9000433 5.65 200.0 µM 5.27E-7 3 8.13E-9 1.79
10 SGTC_2541 muurolladie-3-one 5.07 83.1 µM 5.96E-6 excess fatty acid 10 2.00E-7 0.04
11 SGTC_2576 guaiol 4.91 23.1 µM 1.12E-5 4 4.58E-7 0.18
12 SGTC_115 0527-0192 4.78 112.0 µM 1.83E-5 12 8.80E-7 0.08
13 SGTC_1993 st073995 4.72 70.8 µM 2.26E-5 3 1.16E-6 0.08
14 SGTC_2307 7538926 4.53 6.3 µM 4.67E-5 16 3.02E-6 0.05
15 SGTC_210 3551-0445 4.48 56.8 µM 5.48E-5 10 3.72E-6 0.26
16 SGTC_11 0438-0307 4.48 1.3 µM 5.49E-5 3 3.73E-6 0.09
17 SGTC_1 0258-0098 4.47 57.4 µM 5.75E-5 heme biosynthesis & mitochondrial translocase 14 3.96E-6 0.40
18 SGTC_2797 7859098 4.44 81.8 µM 6.43E-5 8 4.60E-6 0.72
19 SGTC_800 3448-7362 4.29 155.0 µM 1.07E-4 translation 42 8.93E-6 0.02
20 SGTC_429 1112-0049 4.28 25.5 µM 1.10E-4 DNA damage response 7 9.35E-6 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.289 1.05E-65 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.281 4.32E-62 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.249 9.86E-49 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.240 2.31E-45 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.181 4.87E-26 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.142 1.49E-16 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.138 9.34E-16 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.130 3.85E-14 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.122 1.10E-12 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.120 2.92E-12 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
0.110 1.98E-10 YGR116W SPT6 het Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
0.104 1.61E-9 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.100 6.18E-9 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.100 6.72E-9 YOR262W GPN2 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
0.099 1.02E-8 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus