YNL120C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL120C / YNL120C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:2.94|P-value:9.21E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.91|P-value:1.80E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:2.93|P-value:9.76E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.16|P-value:4.09E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.09|P-value:5.50E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.06|P-value:6.03E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.77|P-value:3.35E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:4.88|P-value:1.25E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:4.22|P-value:3.97E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.01|P-value:1.12E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.47|P-value:1.20E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:4.60|P-value:5.66E-7 ID:SGTC_558|Compound:k064-0027|FD-Score:3.74|P-value:3.84E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:3.07|P-value:5.74E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:6.35|P-value:8.99E-12 ID:SGTC_704|Compound:1310-0270|FD-Score:4.71|P-value:3.17E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:3.00|P-value:7.46E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.01|P-value:7.31E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:2.98|P-value:7.97E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.90|P-value:1.87E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.59|P-value:7.25E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.31|P-value:2.35E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.65|P-value:5.70E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.80|P-value:2.95E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.16|P-value:4.12E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.91|P-value:1.75E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.88|P-value:1.98E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.89|P-value:1.18E-7 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.60|P-value:5.70E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.70|P-value:4.58E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.52|P-value:9.71E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.12|P-value:4.88E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.10|P-value:7.16E-6 ID:SGTC_1784|Compound:st039334|FD-Score:-3.48|P-value:1.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.83|P-value:1.62E-7 ID:SGTC_1910|Compound:st062352|FD-Score:8.28|P-value:9.97E-19 ID:SGTC_1947|Compound:st076332|FD-Score:2.96|P-value:8.83E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.64|P-value:4.56E-7 ID:SGTC_2058|Compound:5236698|FD-Score:3.77|P-value:3.31E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-5.10|P-value:3.41E-8 ID:SGTC_2320|Compound:7373003|FD-Score:-3.88|P-value:2.01E-5 ID:SGTC_2373|Compound:9071805|FD-Score:-3.03|P-value:6.83E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.08|P-value:7.90E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.69|P-value:3.57E-7 ID:SGTC_2476|Compound:5806916|FD-Score:3.59|P-value:7.42E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.39|P-value:1.67E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.57|P-value:7.91E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.95|P-value:1.49E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.36|P-value:1.89E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.04|P-value:6.59E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.33|P-value:2.14E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.45|P-value:1.29E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.36|P-value:1.97E-6 ID:SGTC_2962|Compound:9082311|FD-Score:-4.46|P-value:1.17E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-6.18|P-value:3.13E-11 ID:SGTC_3046|Compound:9092212|FD-Score:3.82|P-value:2.70E-5 ID:SGTC_3052|Compound:9092717|FD-Score:7.26|P-value:8.28E-15 ID:SGTC_3054|Compound:9094397|FD-Score:3.91|P-value:1.74E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.79|P-value:3.07E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.11|P-value:5.11E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.00|P-value:7.61E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.64|P-value:6.02E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.68|P-value:4.92E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.37|P-value:1.80E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.90|P-value:1.88E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.62|P-value:6.37E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:2.94|P-value:9.21E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.91|P-value:1.80E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:2.93|P-value:9.76E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.16|P-value:4.09E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.09|P-value:5.50E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.06|P-value:6.03E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.77|P-value:3.35E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:4.88|P-value:1.25E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:4.22|P-value:3.97E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.01|P-value:1.12E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.47|P-value:1.20E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:4.60|P-value:5.66E-7 ID:SGTC_558|Compound:k064-0027|FD-Score:3.74|P-value:3.84E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:3.07|P-value:5.74E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:6.35|P-value:8.99E-12 ID:SGTC_704|Compound:1310-0270|FD-Score:4.71|P-value:3.17E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:3.00|P-value:7.46E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.01|P-value:7.31E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:2.98|P-value:7.97E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.90|P-value:1.87E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.59|P-value:7.25E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.31|P-value:2.35E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.65|P-value:5.70E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.80|P-value:2.95E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.16|P-value:4.12E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.91|P-value:1.75E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.88|P-value:1.98E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.89|P-value:1.18E-7 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.60|P-value:5.70E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.70|P-value:4.58E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.52|P-value:9.71E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.12|P-value:4.88E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.10|P-value:7.16E-6 ID:SGTC_1784|Compound:st039334|FD-Score:-3.48|P-value:1.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.83|P-value:1.62E-7 ID:SGTC_1910|Compound:st062352|FD-Score:8.28|P-value:9.97E-19 ID:SGTC_1947|Compound:st076332|FD-Score:2.96|P-value:8.83E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.64|P-value:4.56E-7 ID:SGTC_2058|Compound:5236698|FD-Score:3.77|P-value:3.31E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-5.10|P-value:3.41E-8 ID:SGTC_2320|Compound:7373003|FD-Score:-3.88|P-value:2.01E-5 ID:SGTC_2373|Compound:9071805|FD-Score:-3.03|P-value:6.83E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.08|P-value:7.90E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.69|P-value:3.57E-7 ID:SGTC_2476|Compound:5806916|FD-Score:3.59|P-value:7.42E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.39|P-value:1.67E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.57|P-value:7.91E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.95|P-value:1.49E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.36|P-value:1.89E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.04|P-value:6.59E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.33|P-value:2.14E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.45|P-value:1.29E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.36|P-value:1.97E-6 ID:SGTC_2962|Compound:9082311|FD-Score:-4.46|P-value:1.17E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-6.18|P-value:3.13E-11 ID:SGTC_3046|Compound:9092212|FD-Score:3.82|P-value:2.70E-5 ID:SGTC_3052|Compound:9092717|FD-Score:7.26|P-value:8.28E-15 ID:SGTC_3054|Compound:9094397|FD-Score:3.91|P-value:1.74E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.79|P-value:3.07E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.11|P-value:5.11E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.00|P-value:7.61E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.64|P-value:6.02E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.68|P-value:4.92E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.37|P-value:1.80E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.90|P-value:1.88E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.62|P-value:6.37E-5

Top fitness defect scores for YNL120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1910 st062352 8.28 60.4 µM 9.97E-19 3 6.16E-17
2 SGTC_3052 9092717 7.26 49.5 µM 8.28E-15 1 1.99E-13
3 SGTC_691 1548-0686 6.35 185.0 µM 8.99E-12 2 1.04E-10
4 SGTC_1457 k015-0032 4.89 57.3 µM 1.18E-7 15 5.15E-7
5 SGTC_307 1501-1223 4.88 22.3 µM 1.25E-7 3 5.40E-7
6 SGTC_1844 rapamycin 4.83 4.0 nM 1.62E-7 120 6.81E-7
7 SGTC_704 1310-0270 4.71 142.0 µM 3.17E-7 21 1.25E-6
8 SGTC_2472 5377652 4.69 49.4 µM 3.57E-7 TRP & mitochondrial translation 36 1.39E-6
9 SGTC_2008 4012253 4.64 172.0 µM 4.56E-7 10 1.73E-6
10 SGTC_465 cgp-37157 4.60 41.0 µM 5.66E-7 8 2.10E-6
11 SGTC_1471 k673-0312 4.60 37.0 µM 5.70E-7 RNA processing & uracil transport 8 2.11E-6
12 SGTC_2960 9079389 4.36 6.0 µM 1.97E-6 17 6.42E-6
13 SGTC_326 k292-0812 4.22 17.5 µM 3.97E-6 4 1.20E-5
14 SGTC_1783 st039459 4.10 87.5 µM 7.16E-6 Golgi 20 2.05E-5
15 SGTC_2461 5755302 4.08 26.1 µM 7.90E-6 29 2.24E-5
16 SGTC_391 gliotoxin 4.01 8.3 µM 1.12E-5 57 3.06E-5
17 SGTC_2679 rapamycin 3.95 1.0 nM 1.49E-5 144 3.96E-5
18 SGTC_3054 9094397 3.91 49.5 µM 1.74E-5 fatty acid desaturase (OLE1) 32 4.55E-5
19 SGTC_1405 3909-7894 3.91 12.0 µM 1.75E-5 60S ribosome export 11 4.58E-5
20 SGTC_78 0336-0123 3.91 156.8 µM 1.80E-5 24 4.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.49E-19 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.140 4.60E-16 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.139 6.13E-16 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.137 1.86E-15 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.132 1.49E-14 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.126 2.16E-13 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.117 1.03E-11 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.115 2.47E-11 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.114 3.54E-11 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.113 5.09E-11 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.113 4.97E-11 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.112 7.22E-11 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.108 3.52E-10 YPL102C_d YPL102C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4
0.108 4.08E-10 YCR017C CWH43 hom Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
0.106 7.64E-10 YOR099W KTR1 hom Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress