YNL121C / TOM70

Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL121C / TOM70

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:4.83|P-value:4.74E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.87|P-value:8.71E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.30|P-value:2.51E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:5.37|P-value:6.99E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.93|P-value:7.40E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.96|P-value:6.79E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.91|P-value:7.93E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.80|P-value:5.19E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.96|P-value:6.72E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:5.44|P-value:5.43E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:5.17|P-value:1.46E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.15|P-value:1.55E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:4.22|P-value:3.17E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.67|P-value:8.03E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.92|P-value:3.51E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.88|P-value:8.60E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.34|P-value:2.23E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:4.50|P-value:1.38E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.00|P-value:2.67E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:3.94|P-value:7.29E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.31|P-value:2.46E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.45|P-value:5.25E-6 ID:SGTC_1953|Compound:st076800|FD-Score:5.75|P-value:1.65E-6 ID:SGTC_1983|Compound:st071813|FD-Score:-4.10|P-value:4.55E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-4.01|P-value:5.80E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.83|P-value:9.73E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.92|P-value:7.57E-4 ID:SGTC_1993|Compound:st073995|FD-Score:6.27|P-value:2.01E-7 ID:SGTC_2006|Compound:4011487|FD-Score:4.14|P-value:4.04E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.83|P-value:9.55E-4 ID:SGTC_2051|Compound:5263410|FD-Score:4.84|P-value:4.53E-5 ID:SGTC_2159|Compound:5658611|FD-Score:4.72|P-value:6.63E-5 ID:SGTC_2197|Compound:6588183|FD-Score:4.89|P-value:3.76E-5 ID:SGTC_2208|Compound:7283366|FD-Score:-4.16|P-value:3.81E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.24|P-value:1.13E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-4.21|P-value:3.28E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.37|P-value:2.05E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.81|P-value:5.01E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.73|P-value:6.49E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.46|P-value:1.54E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.49|P-value:1.42E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.37|P-value:2.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.92|P-value:3.47E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.45|P-value:5.16E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.11|P-value:1.78E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.61|P-value:9.74E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.96|P-value:6.73E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:4.83|P-value:4.74E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.87|P-value:8.71E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.30|P-value:2.51E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:5.37|P-value:6.99E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.93|P-value:7.40E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.96|P-value:6.79E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.91|P-value:7.93E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.80|P-value:5.19E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.96|P-value:6.72E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:5.44|P-value:5.43E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:5.17|P-value:1.46E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.15|P-value:1.55E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:4.22|P-value:3.17E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.67|P-value:8.03E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.92|P-value:3.51E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.88|P-value:8.60E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.34|P-value:2.23E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:4.50|P-value:1.38E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:5.00|P-value:2.67E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:3.94|P-value:7.29E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.31|P-value:2.46E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.45|P-value:5.25E-6 ID:SGTC_1953|Compound:st076800|FD-Score:5.75|P-value:1.65E-6 ID:SGTC_1983|Compound:st071813|FD-Score:-4.10|P-value:4.55E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-4.01|P-value:5.80E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.83|P-value:9.73E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.92|P-value:7.57E-4 ID:SGTC_1993|Compound:st073995|FD-Score:6.27|P-value:2.01E-7 ID:SGTC_2006|Compound:4011487|FD-Score:4.14|P-value:4.04E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.83|P-value:9.55E-4 ID:SGTC_2051|Compound:5263410|FD-Score:4.84|P-value:4.53E-5 ID:SGTC_2159|Compound:5658611|FD-Score:4.72|P-value:6.63E-5 ID:SGTC_2197|Compound:6588183|FD-Score:4.89|P-value:3.76E-5 ID:SGTC_2208|Compound:7283366|FD-Score:-4.16|P-value:3.81E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.24|P-value:1.13E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-4.21|P-value:3.28E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.37|P-value:2.05E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.81|P-value:5.01E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.73|P-value:6.49E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.46|P-value:1.54E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.49|P-value:1.42E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.37|P-value:2.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.92|P-value:3.47E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.45|P-value:5.16E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.11|P-value:1.78E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.61|P-value:9.74E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.96|P-value:6.73E-4

Top fitness defect scores for YNL121C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1993 st073995 6.27 70.8 µM 2.01E-7 2 1.85E-10
2 SGTC_1953 st076800 5.75 12.1 µM 1.65E-6 14 4.47E-9
3 SGTC_2697 mebhydrolin 5.45 72.4 µM 5.16E-6 NEO1 39 2.48E-8
4 SGTC_1425 4048-4433 5.45 7.3 µM 5.25E-6 copper-dependent oxidative stress 15 2.55E-8
5 SGTC_176 1486-1328 5.44 72.8 µM 5.43E-6 28 2.68E-8
6 SGTC_140 0062-0056 5.37 502.5 µM 6.99E-6 7 3.92E-8
7 SGTC_2232 chlorophetanol 5.24 41.5 µM 1.13E-5 TRP & mitochondrial translation 67 8.03E-8
8 SGTC_181 1447-1644 5.17 8.1 µM 1.46E-5 endomembrane recycling 19 1.18E-7
9 SGTC_241 5hr heat shock (37°C) + cantharidin 5.15 155.4 µM 1.55E-5 cell wall signaling 43 1.30E-7
10 SGTC_2749 bexarotene 5.11 57.4 µM 1.78E-5 7 1.60E-7
11 SGTC_881 0833-0569 5.00 170.0 µM 2.67E-5 6 2.94E-7
12 SGTC_2633 5,7-dihydroxyisoflavone 4.92 100.0 µM 3.47E-5 18 4.36E-7
13 SGTC_612 0302-0167 4.92 22.4 µM 3.51E-5 copper-dependent oxidative stress 12 4.43E-7
14 SGTC_2197 6588183 4.89 93.1 µM 3.76E-5 14 4.93E-7
15 SGTC_2051 5263410 4.84 176.0 µM 4.53E-5 11 6.51E-7
16 SGTC_5 0352-0601 4.83 109.9 µM 4.74E-5 ERG2 10 6.95E-7
17 SGTC_2340 7987427 4.81 183.4 µM 5.01E-5 16 7.56E-7
18 SGTC_2366 9070441 4.73 60.6 µM 6.49E-5 16 1.12E-6
19 SGTC_2159 5658611 4.72 73.8 µM 6.63E-5 2 1.15E-6
20 SGTC_541 4513-1321 4.67 94.0 µM 8.03E-5 11 1.54E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.47E-9 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.094 5.22E-8 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.094 5.31E-8 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.090 1.96E-7 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.083 1.75E-6 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.081 3.02E-6 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.080 3.19E-6 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.080 3.63E-6 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.078 6.17E-6 YLR388W RPS29A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication
0.075 1.43E-5 YBR188C NTC20 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.074 1.58E-5 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.073 2.03E-5 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.073 2.17E-5 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.073 2.57E-5 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.071 3.67E-5 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER