YNL123W / NMA111

Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL123W / NMA111

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-15.20|P-value:5.71E-48 ID:SGTC_54|Compound:0159-0055|FD-Score:-6.27|P-value:8.60E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:-5.76|P-value:1.47E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:4.71|P-value:6.17E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:4.55|P-value:1.23E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:4.17|P-value:5.50E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.60|P-value:2.37E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.27|P-value:7.36E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-9.83|P-value:2.85E-21 ID:SGTC_366|Compound:0181-0206|FD-Score:3.45|P-value:7.23E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.44|P-value:1.99E-7 ID:SGTC_404|Compound:fumagillin|FD-Score:4.75|P-value:5.22E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.98|P-value:1.86E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.20|P-value:2.40E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.34|P-value:5.74E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-15.60|P-value:1.58E-50 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.31|P-value:6.40E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:5.77|P-value:3.85E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.66|P-value:1.89E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.66|P-value:3.64E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.47|P-value:1.70E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.92|P-value:2.44E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.62|P-value:4.23E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.38|P-value:9.20E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-6.72|P-value:5.50E-11 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.64|P-value:2.03E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.29|P-value:6.82E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.97|P-value:1.21E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:6.42|P-value:1.05E-9 ID:SGTC_1622|Compound:st003707|FD-Score:3.97|P-value:1.19E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.81|P-value:2.16E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.92|P-value:1.44E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.46|P-value:3.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.82|P-value:2.08E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.58|P-value:1.05E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.45|P-value:1.83E-5 ID:SGTC_1960|Compound:st011366|FD-Score:3.82|P-value:2.08E-4 ID:SGTC_2088|Compound:5278280|FD-Score:6.75|P-value:1.46E-10 ID:SGTC_2098|Compound:5376439|FD-Score:-3.19|P-value:9.47E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.27|P-value:7.21E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.41|P-value:2.17E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.91|P-value:1.51E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.22|P-value:8.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.60|P-value:4.43E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.91|P-value:1.49E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.38|P-value:9.33E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.74|P-value:2.77E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.78|P-value:2.38E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.65|P-value:3.80E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.24|P-value:8.03E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.62|P-value:4.17E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.49|P-value:1.58E-5 ID:SGTC_2825|Compound:7998094|FD-Score:6.60|P-value:3.43E-10 ID:SGTC_2880|Compound:9042983|FD-Score:-3.43|P-value:4.27E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.82|P-value:3.82E-6 ID:SGTC_2884|Compound:9058502|FD-Score:5.19|P-value:6.87E-7 ID:SGTC_2889|Compound:9059656|FD-Score:5.05|P-value:1.31E-6 ID:SGTC_2934|Compound:9036370|FD-Score:4.30|P-value:3.36E-5 ID:SGTC_2937|Compound:9044753|FD-Score:5.48|P-value:1.67E-7 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:5.94E-5 ID:SGTC_3089|Compound:9117425|FD-Score:5.11|P-value:1.02E-6 ID:SGTC_3187|Compound:9109394|FD-Score:4.30|P-value:3.41E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-4.69|P-value:3.02E-6 ID:SGTC_3205|Compound:9113483|FD-Score:3.52|P-value:5.88E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-4.33|P-value:1.43E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.75|P-value:2.69E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.83|P-value:1.02E-4 ID:SGTC_3216|Compound:9129716|FD-Score:5.35|P-value:3.16E-7 ID:SGTC_3224|Compound:9130643|FD-Score:4.44|P-value:1.90E-5 ID:SGTC_3226|Compound:9131256|FD-Score:-3.76|P-value:1.31E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.36|P-value:9.73E-4 ID:SGTC_3250|Compound:9135583|FD-Score:4.83|P-value:3.66E-6 ID:SGTC_3258|Compound:9138477|FD-Score:4.14|P-value:6.40E-5 ID:SGTC_3353|Compound:9151644|FD-Score:5.72|P-value:5.00E-8 ID:SGTC_44|Compound:0929-0055|FD-Score:-15.20|P-value:5.71E-48 ID:SGTC_54|Compound:0159-0055|FD-Score:-6.27|P-value:8.60E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:-5.76|P-value:1.47E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:4.71|P-value:6.17E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:4.55|P-value:1.23E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:4.17|P-value:5.50E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.60|P-value:2.37E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.27|P-value:7.36E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-9.83|P-value:2.85E-21 ID:SGTC_366|Compound:0181-0206|FD-Score:3.45|P-value:7.23E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.44|P-value:1.99E-7 ID:SGTC_404|Compound:fumagillin|FD-Score:4.75|P-value:5.22E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.98|P-value:1.86E-6 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.20|P-value:2.40E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.34|P-value:5.74E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-15.60|P-value:1.58E-50 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.31|P-value:6.40E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:5.77|P-value:3.85E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.66|P-value:1.89E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.66|P-value:3.64E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.47|P-value:1.70E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.92|P-value:2.44E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.62|P-value:4.23E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.38|P-value:9.20E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-6.72|P-value:5.50E-11 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.64|P-value:2.03E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.29|P-value:6.82E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.97|P-value:1.21E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:6.42|P-value:1.05E-9 ID:SGTC_1622|Compound:st003707|FD-Score:3.97|P-value:1.19E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.81|P-value:2.16E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.92|P-value:1.44E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.46|P-value:3.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.82|P-value:2.08E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.58|P-value:1.05E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.45|P-value:1.83E-5 ID:SGTC_1960|Compound:st011366|FD-Score:3.82|P-value:2.08E-4 ID:SGTC_2088|Compound:5278280|FD-Score:6.75|P-value:1.46E-10 ID:SGTC_2098|Compound:5376439|FD-Score:-3.19|P-value:9.47E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.27|P-value:7.21E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.41|P-value:2.17E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.91|P-value:1.51E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.22|P-value:8.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.60|P-value:4.43E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.91|P-value:1.49E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.38|P-value:9.33E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.74|P-value:2.77E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.78|P-value:2.38E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.65|P-value:3.80E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.24|P-value:8.03E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.62|P-value:4.17E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.49|P-value:1.58E-5 ID:SGTC_2825|Compound:7998094|FD-Score:6.60|P-value:3.43E-10 ID:SGTC_2880|Compound:9042983|FD-Score:-3.43|P-value:4.27E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.82|P-value:3.82E-6 ID:SGTC_2884|Compound:9058502|FD-Score:5.19|P-value:6.87E-7 ID:SGTC_2889|Compound:9059656|FD-Score:5.05|P-value:1.31E-6 ID:SGTC_2934|Compound:9036370|FD-Score:4.30|P-value:3.36E-5 ID:SGTC_2937|Compound:9044753|FD-Score:5.48|P-value:1.67E-7 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:5.94E-5 ID:SGTC_3089|Compound:9117425|FD-Score:5.11|P-value:1.02E-6 ID:SGTC_3187|Compound:9109394|FD-Score:4.30|P-value:3.41E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-4.69|P-value:3.02E-6 ID:SGTC_3205|Compound:9113483|FD-Score:3.52|P-value:5.88E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-4.33|P-value:1.43E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.75|P-value:2.69E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.83|P-value:1.02E-4 ID:SGTC_3216|Compound:9129716|FD-Score:5.35|P-value:3.16E-7 ID:SGTC_3224|Compound:9130643|FD-Score:4.44|P-value:1.90E-5 ID:SGTC_3226|Compound:9131256|FD-Score:-3.76|P-value:1.31E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.36|P-value:9.73E-4 ID:SGTC_3250|Compound:9135583|FD-Score:4.83|P-value:3.66E-6 ID:SGTC_3258|Compound:9138477|FD-Score:4.14|P-value:6.40E-5 ID:SGTC_3353|Compound:9151644|FD-Score:5.72|P-value:5.00E-8

Top fitness defect scores for YNL123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2088 5278280 6.75 127.4 µM 1.46E-10 3 7.59E-12
2 SGTC_2825 7998094 6.60 58.4 µM 3.43E-10 fatty acid desaturase (OLE1) 8 1.99E-11
3 SGTC_1489 4065-0444 6.42 182.0 µM 1.05E-9 2 6.98E-11
4 SGTC_961 1252-1571 5.77 372.0 µM 3.85E-8 10 4.07E-9
5 SGTC_3353 9151644 5.72 39.3 µM 5.00E-8 3 5.46E-9
6 SGTC_2937 9044753 5.48 11.3 µM 1.67E-7 60S ribosome export 10 2.14E-8
7 SGTC_373 0844-0104 5.44 25.9 µM 1.99E-7 ERAD & cell cycle 25 2.59E-8
8 SGTC_3216 9129716 5.35 49.5 µM 3.16E-7 RPP1 & pyrimidine depletion 9 4.38E-8
9 SGTC_2884 9058502 5.19 52.0 µM 6.87E-7 9 1.05E-7
10 SGTC_3089 9117425 5.11 49.5 µM 1.02E-6 6 1.65E-7
11 SGTC_2889 9059656 5.05 52.0 µM 1.31E-6 2 2.18E-7
12 SGTC_420 mitomycin C 4.98 81.9 mM 1.86E-6 5 3.25E-7
13 SGTC_1109 tnp00067 4.92 928.3 nM 2.44E-6 4 4.40E-7
14 SGTC_3250 9135583 4.83 49.5 µM 3.66E-6 4 6.97E-7
15 SGTC_2882 9058044 4.82 58.4 µM 3.82E-6 7 7.31E-7
16 SGTC_404 fumagillin 4.75 50.0 µM 5.22E-6 7 1.04E-6
17 SGTC_172 1112-0046 4.71 2.6 µM 6.17E-6 NEO1 24 1.26E-6
18 SGTC_1845 st056753 4.58 3.0 µM 1.05E-5 TSC3-RPN4 24 2.28E-6
19 SGTC_174 3553-0389 4.55 74.3 µM 1.23E-5 12 2.73E-6
20 SGTC_2758 dehydroepiandrosterone 4.49 69.3 µM 1.58E-5 27 3.64E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 3.97E-71 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.291 2.25E-66 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.269 8.88E-57 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.258 2.50E-52 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.245 3.10E-47 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.234 3.62E-43 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.234 4.39E-43 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.222 7.67E-39 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.218 1.57E-37 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.205 3.49E-33 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.201 7.07E-32 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.197 1.10E-30 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.188 5.37E-28 YOR014W RTS1 hom B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A
0.180 7.05E-26 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.180 8.42E-26 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress