YNL124W / NAF1

RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL124W / NAF1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.16|P-value:3.96E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.20|P-value:3.48E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.06|P-value:8.31E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:7.59|P-value:4.10E-16 ID:SGTC_145|Compound:3737-0113|FD-Score:10.70|P-value:3.84E-30 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.20|P-value:3.36E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.39|P-value:1.65E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.06|P-value:5.80E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.14|P-value:4.30E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.42|P-value:1.42E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.92|P-value:9.68E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.13|P-value:4.53E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.55|P-value:8.44E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.43|P-value:1.41E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.08|P-value:5.40E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.80|P-value:1.81E-7 ID:SGTC_657|Compound:3534-0529|FD-Score:5.06|P-value:4.13E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:3.83|P-value:2.43E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.33|P-value:2.24E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:3.52|P-value:9.70E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.61|P-value:6.53E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:3.31|P-value:2.25E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.93|P-value:9.48E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:6.50|P-value:2.75E-12 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.48|P-value:1.10E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.34|P-value:2.00E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.99|P-value:1.20E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.16|P-value:4.03E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-4.47|P-value:1.02E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.46|P-value:1.25E-4 ID:SGTC_1530|Compound:rhein|FD-Score:2.99|P-value:7.71E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.03|P-value:6.69E-4 ID:SGTC_1615|Compound:st002656|FD-Score:2.95|P-value:8.82E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-2.98|P-value:7.93E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.70|P-value:3.12E-7 ID:SGTC_1964|Compound:st076914|FD-Score:-3.65|P-value:5.44E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-4.03|P-value:9.32E-6 ID:SGTC_2050|Compound:5263056|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.00|P-value:7.37E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.29|P-value:2.68E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.04|P-value:6.29E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.20|P-value:3.42E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.37|P-value:1.78E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.92|P-value:9.63E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.07|P-value:6.07E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.16|P-value:4.10E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.18|P-value:3.68E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.21|P-value:3.27E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.47|P-value:1.20E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.34|P-value:1.96E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.25|P-value:2.85E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.22|P-value:3.86E-6 ID:SGTC_3207|Compound:9114163|FD-Score:4.22|P-value:3.85E-6 ID:SGTC_3265|Compound:9137266|FD-Score:3.98|P-value:1.25E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.16|P-value:3.96E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.20|P-value:3.48E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.06|P-value:8.31E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:7.59|P-value:4.10E-16 ID:SGTC_145|Compound:3737-0113|FD-Score:10.70|P-value:3.84E-30 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.20|P-value:3.36E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.39|P-value:1.65E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.06|P-value:5.80E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.14|P-value:4.30E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.42|P-value:1.42E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.92|P-value:9.68E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.13|P-value:4.53E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.55|P-value:8.44E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.43|P-value:1.41E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.08|P-value:5.40E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.80|P-value:1.81E-7 ID:SGTC_657|Compound:3534-0529|FD-Score:5.06|P-value:4.13E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:3.83|P-value:2.43E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.33|P-value:2.24E-6 ID:SGTC_960|Compound:1222-0186|FD-Score:3.52|P-value:9.70E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.61|P-value:6.53E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:3.31|P-value:2.25E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.93|P-value:9.48E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:6.50|P-value:2.75E-12 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.48|P-value:1.10E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.34|P-value:2.00E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.99|P-value:1.20E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.16|P-value:4.03E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-4.47|P-value:1.02E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.46|P-value:1.25E-4 ID:SGTC_1530|Compound:rhein|FD-Score:2.99|P-value:7.71E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.03|P-value:6.69E-4 ID:SGTC_1615|Compound:st002656|FD-Score:2.95|P-value:8.82E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-2.98|P-value:7.93E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.70|P-value:3.12E-7 ID:SGTC_1964|Compound:st076914|FD-Score:-3.65|P-value:5.44E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-4.03|P-value:9.32E-6 ID:SGTC_2050|Compound:5263056|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.00|P-value:7.37E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.29|P-value:2.68E-6 ID:SGTC_2436|Compound:5633522|FD-Score:3.04|P-value:6.29E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.20|P-value:3.42E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.37|P-value:1.78E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.92|P-value:9.63E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.07|P-value:6.07E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.16|P-value:4.10E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.18|P-value:3.68E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.21|P-value:3.27E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.47|P-value:1.20E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.34|P-value:1.96E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.25|P-value:2.85E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.22|P-value:3.86E-6 ID:SGTC_3207|Compound:9114163|FD-Score:4.22|P-value:3.85E-6 ID:SGTC_3265|Compound:9137266|FD-Score:3.98|P-value:1.25E-5

Top fitness defect scores for YNL124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_145 3737-0113 10.70 38.4 µM 3.84E-30 DNA intercalators 4 5.06E-27 2.06
2 SGTC_144 4161-2749 7.59 112.4 µM 4.10E-16 DNA intercalators 3 1.56E-14 1.76
3 SGTC_1150 3909-7983 6.50 10.9 µM 2.75E-12 1 4.01E-11 2.25
4 SGTC_2564 betulinic acid 6.07 100.0 µM 6.07E-11 2 6.32E-10 0.71
5 SGTC_657 3534-0529 5.06 86.7 µM 4.13E-8 2 2.13E-7 1.11
6 SGTC_646 4092-0839 4.80 27.3 µM 1.81E-7 plasma membrane duress 4 7.95E-7 0.41
7 SGTC_1926 methyl fluorone black 4.70 53.6 µM 3.12E-7 DNA intercalators 21 1.29E-6 0.06
8 SGTC_221 trifluoperazine 4.39 10.3 µM 1.65E-6 NEO1-PIK1 26 5.74E-6 0.08
9 SGTC_913 3487-1245 4.33 167.0 µM 2.24E-6 10 7.55E-6 0.14
10 SGTC_2245 6637752 4.29 200.0 µM 2.68E-6 4 8.85E-6 0.20
11 SGTC_3207 9114163 4.22 49.5 µM 3.85E-6 7 1.22E-5 0.04
12 SGTC_3149 9097855 4.22 49.5 µM 3.86E-6 Golgi 7 1.22E-5 0.10
13 SGTC_143 4032-1194 4.06 15.7 µM 8.31E-6 14 2.43E-5 0.06
14 SGTC_1315 1237-0019 3.99 3.7 µM 1.20E-5 7 3.37E-5 0.43
15 SGTC_3265 9137266 3.98 49.5 µM 1.25E-5 3 3.51E-5 0.67
16 SGTC_793 0488-0545 3.83 106.0 µM 2.43E-5 3 6.35E-5 0.39
17 SGTC_1043 0916-0009 3.61 19.3 µM 6.53E-5 8 1.54E-4 0.13
18 SGTC_528 3492-0019 3.55 172.0 µM 8.44E-5 calcium & mitochondrial duress 27 1.94E-4 0.06
19 SGTC_960 1222-0186 3.52 7.7 µM 9.70E-5 13 2.19E-4 0.03
20 SGTC_2988 9073640 3.47 71.4 µM 1.20E-4 16 2.65E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.342 1.22E-92 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.304 7.36E-73 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.300 1.42E-70 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.260 7.26E-53 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.252 9.60E-50 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.238 2.01E-44 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.237 3.24E-44 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.231 1.04E-41 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.214 4.64E-36 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.213 8.19E-36 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.211 7.23E-35 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.208 3.00E-34 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.207 9.37E-34 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.206 1.38E-33 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.202 4.15E-32 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters