YNL126W / SPC98

Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL126W / SPC98

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:4.42|P-value:1.53E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.49|P-value:3.96E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:4.18|P-value:3.15E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.98|P-value:2.47E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.74|P-value:5.40E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.60|P-value:2.58E-6 ID:SGTC_252|Compound:miconazole|FD-Score:-4.08|P-value:6.45E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.21|P-value:2.86E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.75|P-value:5.37E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.85|P-value:3.77E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:5.50|P-value:3.71E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:4.72|P-value:5.83E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.90|P-value:7.07E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.80|P-value:4.42E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:4.36|P-value:1.82E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.15|P-value:3.44E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.69|P-value:2.70E-8 ID:SGTC_674|Compound:0498-0004|FD-Score:4.20|P-value:2.97E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.79|P-value:9.39E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:16.10|P-value:6.83E-39 ID:SGTC_951|Compound:1171-0579|FD-Score:4.35|P-value:1.86E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.26|P-value:3.83E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.37|P-value:1.75E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:5.61|P-value:2.50E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.32|P-value:2.08E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-8.68|P-value:2.42E-12 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.82|P-value:8.72E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:7.24|P-value:2.12E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.99|P-value:3.88E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.70|P-value:1.75E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.93|P-value:6.50E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.91|P-value:3.05E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.30|P-value:2.17E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.14|P-value:3.49E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.84|P-value:8.25E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.15|P-value:3.44E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.55|P-value:5.12E-8 ID:SGTC_1749|Compound:st037932|FD-Score:3.97|P-value:5.70E-4 ID:SGTC_1766|Compound:st045414|FD-Score:6.05|P-value:4.23E-7 ID:SGTC_1774|Compound:st048371|FD-Score:4.98|P-value:2.46E-5 ID:SGTC_1832|Compound:st054113|FD-Score:4.88|P-value:3.48E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.51|P-value:1.17E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.39|P-value:1.67E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:5.63|P-value:2.25E-6 ID:SGTC_2041|Compound:5107442|FD-Score:6.04|P-value:4.40E-7 ID:SGTC_2057|Compound:5236571|FD-Score:4.62|P-value:8.01E-5 ID:SGTC_2109|Compound:5483026|FD-Score:5.22|P-value:1.03E-5 ID:SGTC_2156|Compound:5649887|FD-Score:4.61|P-value:8.34E-5 ID:SGTC_2186|Compound:6124449|FD-Score:4.89|P-value:3.29E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.93|P-value:2.93E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.27|P-value:2.37E-4 ID:SGTC_2277|Compound:7947813|FD-Score:8.45|P-value:3.62E-12 ID:SGTC_2289|Compound:7946404|FD-Score:5.56|P-value:2.97E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.85|P-value:8.11E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.96|P-value:5.91E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.91|P-value:6.83E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.76|P-value:5.07E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.34|P-value:6.68E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.99|P-value:5.45E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.63|P-value:1.26E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.53|P-value:1.08E-4 ID:SGTC_3050|Compound:9093513|FD-Score:6.81|P-value:1.59E-8 ID:SGTC_3124|Compound:9127567|FD-Score:4.51|P-value:1.14E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.79|P-value:7.46E-5 ID:SGTC_3266|Compound:9136860|FD-Score:4.56|P-value:9.91E-5 ID:SGTC_3311|Compound:9131146|FD-Score:7.98|P-value:4.93E-11 ID:SGTC_3322|Compound:9139058|FD-Score:4.24|P-value:2.63E-4 ID:SGTC_3331|Compound:9141060|FD-Score:5.52|P-value:3.46E-6 ID:SGTC_3350|Compound:9150499|FD-Score:7.73|P-value:1.77E-10 ID:SGTC_93|Compound:0109-0045|FD-Score:4.42|P-value:1.53E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.49|P-value:3.96E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:4.18|P-value:3.15E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.98|P-value:2.47E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:4.74|P-value:5.40E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.60|P-value:2.58E-6 ID:SGTC_252|Compound:miconazole|FD-Score:-4.08|P-value:6.45E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.21|P-value:2.86E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.75|P-value:5.37E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.85|P-value:3.77E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:5.50|P-value:3.71E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:4.72|P-value:5.83E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.90|P-value:7.07E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.80|P-value:4.42E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:4.36|P-value:1.82E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.15|P-value:3.44E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.69|P-value:2.70E-8 ID:SGTC_674|Compound:0498-0004|FD-Score:4.20|P-value:2.97E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.79|P-value:9.39E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:16.10|P-value:6.83E-39 ID:SGTC_951|Compound:1171-0579|FD-Score:4.35|P-value:1.86E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.26|P-value:3.83E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.37|P-value:1.75E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:5.61|P-value:2.50E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.32|P-value:2.08E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-8.68|P-value:2.42E-12 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.82|P-value:8.72E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:7.24|P-value:2.12E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.99|P-value:3.88E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.70|P-value:1.75E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.93|P-value:6.50E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.91|P-value:3.05E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.30|P-value:2.17E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.14|P-value:3.49E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.84|P-value:8.25E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:4.15|P-value:3.44E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.55|P-value:5.12E-8 ID:SGTC_1749|Compound:st037932|FD-Score:3.97|P-value:5.70E-4 ID:SGTC_1766|Compound:st045414|FD-Score:6.05|P-value:4.23E-7 ID:SGTC_1774|Compound:st048371|FD-Score:4.98|P-value:2.46E-5 ID:SGTC_1832|Compound:st054113|FD-Score:4.88|P-value:3.48E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.51|P-value:1.17E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.39|P-value:1.67E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:5.63|P-value:2.25E-6 ID:SGTC_2041|Compound:5107442|FD-Score:6.04|P-value:4.40E-7 ID:SGTC_2057|Compound:5236571|FD-Score:4.62|P-value:8.01E-5 ID:SGTC_2109|Compound:5483026|FD-Score:5.22|P-value:1.03E-5 ID:SGTC_2156|Compound:5649887|FD-Score:4.61|P-value:8.34E-5 ID:SGTC_2186|Compound:6124449|FD-Score:4.89|P-value:3.29E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.93|P-value:2.93E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.27|P-value:2.37E-4 ID:SGTC_2277|Compound:7947813|FD-Score:8.45|P-value:3.62E-12 ID:SGTC_2289|Compound:7946404|FD-Score:5.56|P-value:2.97E-6 ID:SGTC_2357|Compound:9067248|FD-Score:3.85|P-value:8.11E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.96|P-value:5.91E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.91|P-value:6.83E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.76|P-value:5.07E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.34|P-value:6.68E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.99|P-value:5.45E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.63|P-value:1.26E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.53|P-value:1.08E-4 ID:SGTC_3050|Compound:9093513|FD-Score:6.81|P-value:1.59E-8 ID:SGTC_3124|Compound:9127567|FD-Score:4.51|P-value:1.14E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.79|P-value:7.46E-5 ID:SGTC_3266|Compound:9136860|FD-Score:4.56|P-value:9.91E-5 ID:SGTC_3311|Compound:9131146|FD-Score:7.98|P-value:4.93E-11 ID:SGTC_3322|Compound:9139058|FD-Score:4.24|P-value:2.63E-4 ID:SGTC_3331|Compound:9141060|FD-Score:5.52|P-value:3.46E-6 ID:SGTC_3350|Compound:9150499|FD-Score:7.73|P-value:1.77E-10

Top fitness defect scores for YNL126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_916 4466-0038 16.10 42.0 nM 6.83E-39 cell wall 2 1.40E-58 1.26
2 SGTC_2277 7947813 8.45 106.9 µM 3.62E-12 RSC complex & mRNA processing 3 1.41E-17 0.97
3 SGTC_3311 9131146 7.98 2.9 µM 4.93E-11 cell wall 5 7.53E-16 1.70
4 SGTC_3350 9150499 7.73 3.6 µM 1.77E-10 cell wall 3 5.28E-15 0.80
5 SGTC_1203 3992-3522 7.24 103.0 µM 2.12E-9 1 2.30E-13 0.91
6 SGTC_3050 9093513 6.81 49.5 µM 1.59E-8 1 4.90E-12 1.10
7 SGTC_673 1082-0474 6.69 110.0 µM 2.70E-8 RSC complex & mRNA processing 24 1.10E-11 0.16
8 SGTC_1652 st011932 6.55 78.0 µM 5.12E-8 RSC complex & mRNA processing 20 2.89E-11 0.13
9 SGTC_1766 st045414 6.05 44.8 µM 4.23E-7 RPP1 & pyrimidine depletion 6 7.07E-10 0.22
10 SGTC_2041 5107442 6.04 45.3 µM 4.40E-7 RSC complex & mRNA processing 16 7.50E-10 0.06
11 SGTC_1229 0139-0193 5.70 12.2 µM 1.75E-6 RSC complex & mRNA processing 12 6.03E-9 0.19
12 SGTC_1880 MG-132 5.63 525.0 µM 2.25E-6 10 8.83E-9 0.11
13 SGTC_1101 ebselen 5.61 5.3 µM 2.50E-6 2 1.03E-8 0.42
14 SGTC_241 5hr heat shock (37°C) + cantharidin 5.60 155.4 µM 2.58E-6 cell wall signaling 8 1.08E-8 0.31
15 SGTC_2289 7946404 5.56 165.1 µM 2.97E-6 8 1.34E-8 0.03
16 SGTC_3331 9141060 5.52 2.0 µM 3.46E-6 cell wall 3 1.69E-8 1.17
17 SGTC_550 4123-0385 5.50 25.7 µM 3.71E-6 TSC3-RPN4 2 1.87E-8 0.15
18 SGTC_108 0509-0257 5.49 621.1 µM 3.96E-6 8 2.07E-8 0.22
19 SGTC_2619 obliquin 5.34 87.9 µM 6.68E-6 cell wall 20 4.54E-8 0.04
20 SGTC_2109 5483026 5.22 200.0 µM 1.03E-5 RSC complex & mRNA processing 23 8.72E-8 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.275 2.56E-59 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.250 7.85E-49 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.229 4.16E-41 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.223 6.25E-39 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.208 3.74E-34 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.203 1.13E-32 YBR196C PGI1 het Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
0.197 9.20E-31 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.191 6.86E-29 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.184 5.61E-27 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.176 7.92E-25 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.175 1.42E-24 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.173 5.75E-24 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.167 1.83E-22 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.166 3.41E-22 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.166 3.85E-22 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes