YNL127W / FAR11

Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL127W / FAR11

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:3.72E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.72|P-value:1.91E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:8.83|P-value:1.51E-15 ID:SGTC_105|Compound:0111-0055|FD-Score:3.74|P-value:5.06E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.60|P-value:7.90E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.56|P-value:1.17E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.93|P-value:2.74E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.95|P-value:2.57E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.77|P-value:1.26E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.25|P-value:3.98E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.63|P-value:2.15E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:4.05|P-value:1.83E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.56|P-value:9.02E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.48|P-value:5.82E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.75|P-value:4.94E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.55|P-value:4.56E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:6.29|P-value:1.14E-8 ID:SGTC_1081|Compound:sertraline|FD-Score:3.54|P-value:9.52E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.63|P-value:3.50E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.72|P-value:1.52E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.72|P-value:1.50E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.62|P-value:2.22E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.02|P-value:2.01E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.36|P-value:9.96E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.60|P-value:7.83E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.54|P-value:3.02E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.54|P-value:4.80E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.83|P-value:3.87E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.59|P-value:8.19E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.85|P-value:3.58E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.66|P-value:3.24E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:-3.48|P-value:5.73E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.99|P-value:2.23E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.74|P-value:5.07E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.66|P-value:6.57E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.49|P-value:3.75E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.67|P-value:6.35E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.27|P-value:8.22E-5 ID:SGTC_1733|Compound:st037357|FD-Score:6.73|P-value:1.06E-9 ID:SGTC_1771|Compound:st048882|FD-Score:3.64|P-value:7.12E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.09|P-value:1.60E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.98|P-value:5.27E-6 ID:SGTC_1820|Compound:st053765|FD-Score:3.94|P-value:2.64E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.66|P-value:6.59E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.05|P-value:1.82E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.61|P-value:2.35E-5 ID:SGTC_2203|Compound:7227154|FD-Score:4.04|P-value:1.86E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.00|P-value:4.87E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-3.37|P-value:8.09E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.91|P-value:2.91E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.27|P-value:8.30E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.26|P-value:8.52E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.35|P-value:8.32E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.89|P-value:3.13E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.87|P-value:3.31E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.15|P-value:1.28E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.93|P-value:6.50E-6 ID:SGTC_2699|Compound:st077704|FD-Score:3.80|P-value:4.26E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.32|P-value:1.19E-6 ID:SGTC_3187|Compound:9109394|FD-Score:7.06|P-value:1.59E-10 ID:SGTC_3207|Compound:9114163|FD-Score:4.10|P-value:1.54E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.52|P-value:5.05E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.86|P-value:3.46E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:3.72E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.72|P-value:1.91E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:8.83|P-value:1.51E-15 ID:SGTC_105|Compound:0111-0055|FD-Score:3.74|P-value:5.06E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.60|P-value:7.90E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.56|P-value:1.17E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.93|P-value:2.74E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.95|P-value:2.57E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.77|P-value:1.26E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.25|P-value:3.98E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.63|P-value:2.15E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:4.05|P-value:1.83E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.56|P-value:9.02E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.48|P-value:5.82E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.75|P-value:4.94E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.55|P-value:4.56E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:6.29|P-value:1.14E-8 ID:SGTC_1081|Compound:sertraline|FD-Score:3.54|P-value:9.52E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.63|P-value:3.50E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.72|P-value:1.52E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.72|P-value:1.50E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.62|P-value:2.22E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.02|P-value:2.01E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.36|P-value:9.96E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.60|P-value:7.83E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.54|P-value:3.02E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.54|P-value:4.80E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.83|P-value:3.87E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.59|P-value:8.19E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.85|P-value:3.58E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.66|P-value:3.24E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:-3.48|P-value:5.73E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.99|P-value:2.23E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.74|P-value:5.07E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.66|P-value:6.57E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.49|P-value:3.75E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.67|P-value:6.35E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.27|P-value:8.22E-5 ID:SGTC_1733|Compound:st037357|FD-Score:6.73|P-value:1.06E-9 ID:SGTC_1771|Compound:st048882|FD-Score:3.64|P-value:7.12E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.09|P-value:1.60E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.98|P-value:5.27E-6 ID:SGTC_1820|Compound:st053765|FD-Score:3.94|P-value:2.64E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.66|P-value:6.59E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.05|P-value:1.82E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.61|P-value:2.35E-5 ID:SGTC_2203|Compound:7227154|FD-Score:4.04|P-value:1.86E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.00|P-value:4.87E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-3.37|P-value:8.09E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.91|P-value:2.91E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.27|P-value:8.30E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.26|P-value:8.52E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.35|P-value:8.32E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.89|P-value:3.13E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.87|P-value:3.31E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.15|P-value:1.28E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.93|P-value:6.50E-6 ID:SGTC_2699|Compound:st077704|FD-Score:3.80|P-value:4.26E-4 ID:SGTC_2842|Compound:9000675|FD-Score:5.32|P-value:1.19E-6 ID:SGTC_3187|Compound:9109394|FD-Score:7.06|P-value:1.59E-10 ID:SGTC_3207|Compound:9114163|FD-Score:4.10|P-value:1.54E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.52|P-value:5.05E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.86|P-value:3.46E-4

Top fitness defect scores for YNL127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 8.83 51.8 µM 1.51E-15 ERAD & cell cycle 39 5.33E-19
2 SGTC_3187 9109394 7.06 49.5 µM 1.59E-10 Golgi 2 8.34E-13
3 SGTC_1733 st037357 6.73 54.9 µM 1.06E-9 60S ribosome export 3 8.59E-12
4 SGTC_2582 agaric acid 6.35 100.0 µM 8.32E-9 redox potentiating 145 1.10E-10
5 SGTC_1073 triclabendazole 6.29 3.1 µM 1.14E-8 6 1.62E-10
6 SGTC_64 000l-0018 5.72 272.1 µM 1.91E-7 ubiquinone biosynthesis & proteasome 84 5.29E-9
7 SGTC_733 4069-0007 5.48 56.1 µM 5.82E-7 ERAD & cell cycle 46 2.10E-8
8 SGTC_1241 0364-0022 5.36 50.8 µM 9.96E-7 ERG2 9 4.08E-8
9 SGTC_2842 9000675 5.32 19.5 µM 1.19E-6 3 5.09E-8
10 SGTC_2322 7413319 5.00 38.2 µM 4.87E-6 ERAD & cell cycle 98 2.90E-7
11 SGTC_1815 st051655 4.98 58.2 µM 5.27E-6 TSC3-RPN4 5 3.20E-7
12 SGTC_2692 st077426 4.93 47.7 µM 6.50E-6 8 4.14E-7
13 SGTC_269 exalamide 4.77 29.0 µM 1.26E-5 ergosterol biosynthesis 9 9.39E-7
14 SGTC_1106 tegaserod maleate 4.72 11.7 µM 1.50E-5 7 1.17E-6
15 SGTC_1085 doxorubicin 4.72 7.7 µM 1.52E-5 anthracycline transcription coupled DNA repair 6 1.19E-6
16 SGTC_568 1193-0097 4.63 7.5 µM 2.15E-5 ERAD & cell cycle 106 1.83E-6
17 SGTC_1161 k007-0610 4.62 110.0 µM 2.22E-5 ERAD & cell cycle 93 1.89E-6
18 SGTC_2183 6420625 4.61 130.5 µM 2.35E-5 mitochondrial processes 36 2.04E-6
19 SGTC_1261 0712-0010 4.54 12.7 µM 3.02E-5 RNA processing & uracil transport 14 2.78E-6
20 SGTC_1429 4049-0205 4.49 9.5 µM 3.75E-5 3 3.63E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 3.04E-48 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.216 1.28E-36 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.209 1.61E-34 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.205 2.98E-33 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.201 9.36E-32 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.193 1.91E-29 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.193 1.96E-29 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.191 8.83E-29 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.189 2.26E-28 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.182 1.65E-26 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.176 1.16E-24 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.175 1.79E-24 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.175 2.09E-24 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.173 6.33E-24 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.171 2.77E-23 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases