YNL130C-A_p / DGR1

Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL130C-A / DGR1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:2.99|P-value:6.35E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.93|P-value:8.25E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.16|P-value:3.30E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.12|P-value:3.98E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.22|P-value:2.75E-6 ID:SGTC_281|Compound:1672-3440|FD-Score:3.51|P-value:7.84E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.15|P-value:3.50E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.62|P-value:4.93E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.00|P-value:6.06E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.20|P-value:2.86E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.03|P-value:7.08E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.83|P-value:1.89E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.76|P-value:2.54E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.11|P-value:4.20E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.02|P-value:5.82E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.21|P-value:2.78E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.07|P-value:4.77E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.31|P-value:1.83E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.06|P-value:6.30E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.45|P-value:1.03E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.70|P-value:3.49E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.17|P-value:3.19E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.67|P-value:3.89E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.28|P-value:2.15E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.11|P-value:3.99E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.85|P-value:8.82E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.09|P-value:4.31E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.06|P-value:4.90E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.32|P-value:1.70E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.72|P-value:3.06E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:2.94|P-value:7.64E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.90|P-value:6.63E-8 ID:SGTC_1570|Compound:verbenone|FD-Score:4.19|P-value:3.27E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.22|P-value:2.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.07|P-value:5.95E-6 ID:SGTC_1655|Compound:st012546|FD-Score:3.22|P-value:2.61E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.52|P-value:7.57E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.29|P-value:1.91E-6 ID:SGTC_1767|Compound:st044992|FD-Score:2.91|P-value:8.49E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.30|P-value:1.88E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-2.92|P-value:8.47E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.29|P-value:2.02E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.28|P-value:2.11E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-3.13|P-value:3.85E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.82|P-value:1.99E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.17|P-value:3.25E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.34|P-value:1.52E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.99|P-value:8.86E-6 ID:SGTC_2340|Compound:7987427|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.40|P-value:1.28E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.49|P-value:8.81E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.91|P-value:8.75E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.89|P-value:9.27E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.82|P-value:1.97E-5 ID:SGTC_2709|Compound:st078560|FD-Score:-3.12|P-value:4.00E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.27|P-value:2.15E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:2.99|P-value:6.35E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.93|P-value:8.25E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.29|P-value:2.01E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.16|P-value:3.30E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:-3.12|P-value:3.98E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.22|P-value:2.75E-6 ID:SGTC_281|Compound:1672-3440|FD-Score:3.51|P-value:7.84E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.15|P-value:3.50E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.62|P-value:4.93E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.00|P-value:6.06E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.20|P-value:2.86E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.03|P-value:7.08E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.83|P-value:1.89E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.76|P-value:2.54E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.11|P-value:4.20E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.02|P-value:5.82E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.21|P-value:2.78E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.07|P-value:4.77E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.31|P-value:1.83E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.06|P-value:6.30E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.45|P-value:1.03E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.70|P-value:3.49E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.17|P-value:3.19E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.67|P-value:3.89E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.28|P-value:2.15E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.11|P-value:3.99E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.85|P-value:8.82E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.09|P-value:4.31E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.06|P-value:4.90E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.32|P-value:1.70E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.72|P-value:3.06E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:2.94|P-value:7.64E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.90|P-value:6.63E-8 ID:SGTC_1570|Compound:verbenone|FD-Score:4.19|P-value:3.27E-6 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.22|P-value:2.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.07|P-value:5.95E-6 ID:SGTC_1655|Compound:st012546|FD-Score:3.22|P-value:2.61E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.52|P-value:7.57E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.29|P-value:1.91E-6 ID:SGTC_1767|Compound:st044992|FD-Score:2.91|P-value:8.49E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.30|P-value:1.88E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-2.92|P-value:8.47E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.29|P-value:2.02E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-4.28|P-value:2.11E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-3.13|P-value:3.85E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.82|P-value:1.99E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.17|P-value:3.25E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.34|P-value:1.52E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.99|P-value:8.86E-6 ID:SGTC_2340|Compound:7987427|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.40|P-value:1.28E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.49|P-value:8.81E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.91|P-value:8.75E-4 ID:SGTC_2625|Compound:euphol|FD-Score:2.89|P-value:9.27E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.82|P-value:1.97E-5 ID:SGTC_2709|Compound:st078560|FD-Score:-3.12|P-value:4.00E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.27|P-value:2.15E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.39|P-value:1.30E-4

Top fitness defect scores for YNL130C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1545 lovastatin 4.90 49.4 µM 6.63E-8 9 4.80E-7
2 SGTC_1260 0700-1617 4.85 7.8 µM 8.82E-8 calcium & mitochondrial duress 16 6.14E-7
3 SGTC_1748 st037455 4.29 53.6 µM 1.91E-6 22 8.88E-6
4 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.22 819.4 µM 2.75E-6 heat shock/prefoldin 32 1.22E-5
5 SGTC_1570 verbenone 4.19 133.0 µM 3.27E-6 13 1.42E-5
6 SGTC_1635 st007035 4.07 42.4 µM 5.95E-6 205 2.38E-5
7 SGTC_1166 k206-0078 4.06 225.0 µM 6.30E-6 19 2.50E-5
8 SGTC_655 k060-0012 4.03 42.0 µM 7.08E-6 10 2.77E-5
9 SGTC_2331 7980721 3.99 200.0 µM 8.86E-6 25 3.36E-5
10 SGTC_2704 st078022 3.82 71.1 µM 1.97E-5 16 6.74E-5
11 SGTC_2288 7946289 3.82 167.3 µM 1.99E-5 31 6.78E-5
12 SGTC_784 4579-0127 3.76 173.0 µM 2.54E-5 26 8.41E-5
13 SGTC_1519 esterone 3.72 74.0 µM 3.06E-5 DNA intercalators 22 9.87E-5
14 SGTC_1229 0139-0193 3.67 12.2 µM 3.89E-5 RSC complex & mRNA processing 18 1.22E-4
15 SGTC_558 k064-0027 3.62 21.3 µM 4.93E-5 DNA damage response 32 1.50E-4
16 SGTC_1700 st030840 3.52 7.9 µM 7.57E-5 PDR1 33 2.17E-4
17 SGTC_281 1672-3440 3.51 14.9 µM 7.84E-5 Golgi 10 2.24E-4
18 SGTC_2379 9035213 3.40 200.0 µM 1.28E-4 44 3.43E-4
19 SGTC_3090 9117696 3.39 49.5 µM 1.30E-4 25 3.48E-4
20 SGTC_1165 k072-0275 3.31 30.3 µM 1.83E-4 67 4.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.98E-17 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.132 2.03E-14 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.122 1.49E-12 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.119 3.77E-12 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.112 7.94E-11 YBR296C PHO89 hom Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification
0.110 1.70E-10 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.109 2.08E-10 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.099 7.87E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.099 7.91E-9 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.099 1.01E-8 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.095 3.49E-8 YGL006W-A_p YGL006W-A_p hom Putative protein of unknown function; identified by SAGE
0.094 4.38E-8 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.092 8.53E-8 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.092 8.87E-8 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.092 1.07E-7 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p