YNL131W / TOM22

Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL131W / TOM22

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-4.00|P-value:9.07E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:8.31|P-value:3.58E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:7.69|P-value:8.05E-10 ID:SGTC_122|Compound:0236-0016|FD-Score:-5.78|P-value:3.22E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.47|P-value:2.43E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.13|P-value:5.86E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-6.25|P-value:5.19E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:4.00|P-value:8.47E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.08|P-value:3.39E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.03|P-value:4.33E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.24|P-value:2.12E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.92|P-value:6.07E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.00|P-value:8.39E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.00|P-value:8.46E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.98|P-value:8.86E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.83|P-value:7.48E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:4.08|P-value:6.72E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.46|P-value:9.29E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.09|P-value:7.11E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.52|P-value:1.96E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.42|P-value:2.79E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.98|P-value:8.91E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:6.43|P-value:2.32E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.43|P-value:2.52E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.87|P-value:6.70E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-6.34|P-value:3.59E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-5.71|P-value:4.04E-6 ID:SGTC_1634|Compound:st006576|FD-Score:6.33|P-value:3.44E-7 ID:SGTC_1638|Compound:st008370|FD-Score:7.58|P-value:1.40E-9 ID:SGTC_1815|Compound:st051655|FD-Score:4.60|P-value:1.54E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.98|P-value:8.96E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.69|P-value:7.84E-8 ID:SGTC_2396|Compound:5342950|FD-Score:-4.33|P-value:3.60E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.31|P-value:3.54E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.06|P-value:7.66E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.84|P-value:7.29E-5 ID:SGTC_33|Compound:0986-0033|FD-Score:-4.00|P-value:9.07E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:8.31|P-value:3.58E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:7.69|P-value:8.05E-10 ID:SGTC_122|Compound:0236-0016|FD-Score:-5.78|P-value:3.22E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.47|P-value:2.43E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.13|P-value:5.86E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-6.25|P-value:5.19E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:4.00|P-value:8.47E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:5.08|P-value:3.39E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.03|P-value:4.33E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.24|P-value:2.12E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-4.92|P-value:6.07E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:4.00|P-value:8.39E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.00|P-value:8.46E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.98|P-value:8.86E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.83|P-value:7.48E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:4.08|P-value:6.72E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.46|P-value:9.29E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.09|P-value:7.11E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.52|P-value:1.96E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.42|P-value:2.79E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.98|P-value:8.91E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:6.43|P-value:2.32E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.43|P-value:2.52E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.87|P-value:6.70E-5 ID:SGTC_1630|Compound:st005209|FD-Score:-6.34|P-value:3.59E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-5.71|P-value:4.04E-6 ID:SGTC_1634|Compound:st006576|FD-Score:6.33|P-value:3.44E-7 ID:SGTC_1638|Compound:st008370|FD-Score:7.58|P-value:1.40E-9 ID:SGTC_1815|Compound:st051655|FD-Score:4.60|P-value:1.54E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.98|P-value:8.96E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.69|P-value:7.84E-8 ID:SGTC_2396|Compound:5342950|FD-Score:-4.33|P-value:3.60E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.31|P-value:3.54E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.06|P-value:7.66E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.84|P-value:7.29E-5

Top fitness defect scores for YNL131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_104 0074-0074 8.31 591.0 µM 3.58E-11 2 4.67E-17 2.12
2 SGTC_108 0509-0257 7.69 621.1 µM 8.05E-10 2 7.13E-15 0.55
3 SGTC_1638 st008370 7.58 60.6 µM 1.40E-9 ergosterol biosynthesis 1 1.73E-14 0.87
4 SGTC_2004 4023728 6.69 41.9 µM 7.84E-8 14 1.14E-11 0.67
5 SGTC_1243 0416-0003 6.43 5.7 µM 2.32E-7 PDR1 1 6.55E-11 2.04
6 SGTC_1634 st006576 6.33 41.0 µM 3.44E-7 TSC3-RPN4 2 1.23E-10 1.66
7 SGTC_743 1275-0778 5.46 158.0 µM 9.29E-6 excess fatty acid 6 2.43E-8 0.45
8 SGTC_273 hydroxyurea 5.08 18.1 mM 3.39E-5 heme biosynthesis & mitochondrial translocase 13 1.92E-7 0.27
9 SGTC_1629 st005085 4.87 44.9 µM 6.70E-5 RPP1 & pyrimidine depletion 10 5.70E-7 0.04
10 SGTC_2790 5423970 4.84 71.4 µM 7.29E-5 endomembrane recycling 9 6.53E-7 0.07
11 SGTC_628 1636-0253 4.83 16.0 µM 7.48E-5 sphingolipid biosynthesis & PDR1 3 6.80E-7 0.33
12 SGTC_1815 st051655 4.60 58.2 µM 1.54E-4 TSC3-RPN4 8 2.15E-6 0.07
13 SGTC_818 4072-2707 4.52 53.5 µM 1.96E-4 5 3.14E-6 0.13
14 SGTC_1357 1503-1303 4.43 39.5 µM 2.52E-4 4 4.68E-6 0.23
15 SGTC_2617 dihydrotanshinone i 4.31 20.8 µM 3.54E-4 copper-dependent oxidative stress 16 8.04E-6 0.08
16 SGTC_131 0141-0277 4.13 33.9 µM 5.86E-4 9 1.79E-5 0.07
17 SGTC_664 1222-0054 4.08 14.9 µM 6.72E-4 sphingolipid biosynthesis & PDR1 8 2.22E-5 0.20
18 SGTC_515 4092-1064 4.00 102.0 µM 8.39E-4 plasma membrane duress 18 3.16E-5 0.03
19 SGTC_589 1227-0070 4.00 34.1 µM 8.46E-4 9 3.20E-5 0.09
20 SGTC_139 0099-0334 4.00 718.6 µM 8.47E-4 4 3.20E-5 6.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.291 2.74E-66 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.249 9.86E-49 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.159 2.44E-20 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.156 1.19E-19 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.148 8.39E-18 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.141 1.89E-16 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.137 1.58E-15 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.130 3.79E-14 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.118 6.62E-12 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
0.118 7.61E-12 YOR326W MYO2 het Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication
0.113 4.89E-11 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.110 1.90E-10 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.107 4.35E-10 YKL165C MCD4 het Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
0.106 8.65E-10 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.104 1.53E-9 YCR052W RSC6 het Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p