YNL133C / FYV6

Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL133C / FYV6

Click on Significant Values for Screen Details ID:SGTC_111|Compound:0083-0039|FD-Score:-3.81|P-value:5.41E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.73|P-value:7.35E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.54|P-value:5.43E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.89|P-value:4.57E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-5.10|P-value:6.16E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-4.21|P-value:1.55E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.65|P-value:9.47E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.30|P-value:1.15E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.26|P-value:1.41E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.61|P-value:9.75E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-4.22|P-value:1.47E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-4.11|P-value:2.12E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.86|P-value:1.69E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-4.71|P-value:2.76E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.24|P-value:1.53E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.00|P-value:1.02E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.94|P-value:3.67E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:6.78|P-value:3.67E-9 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.88|P-value:4.36E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.72|P-value:7.72E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.04|P-value:2.87E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.64|P-value:9.55E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.73|P-value:7.53E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.14|P-value:2.06E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-5.30|P-value:2.87E-6 ID:SGTC_2116|Compound:5511452|FD-Score:-5.04|P-value:7.78E-6 ID:SGTC_2166|Compound:5933061|FD-Score:4.20|P-value:1.74E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-3.93|P-value:3.83E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-5.99|P-value:1.48E-7 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.83|P-value:1.93E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.17|P-value:1.88E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.26|P-value:3.38E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.30|P-value:1.13E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.97|P-value:1.74E-7 ID:SGTC_2421|Compound:5690543|FD-Score:-4.22|P-value:1.48E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.17|P-value:1.77E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.70|P-value:7.63E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:5.51|P-value:1.32E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:4.08|P-value:2.51E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.96|P-value:3.65E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.70|P-value:3.13E-5 ID:SGTC_2871|Compound:9038510|FD-Score:-5.11|P-value:6.11E-6 ID:SGTC_2880|Compound:9042983|FD-Score:-4.69|P-value:2.95E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.80|P-value:6.01E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.72|P-value:7.14E-4 ID:SGTC_2902|Compound:5787006|FD-Score:8.58|P-value:1.20E-13 ID:SGTC_2904|Compound:7225135|FD-Score:-5.31|P-value:2.73E-6 ID:SGTC_2912|Compound:7964298|FD-Score:6.74|P-value:4.55E-9 ID:SGTC_2915|Compound:7971052|FD-Score:5.80|P-value:3.73E-7 ID:SGTC_3004|Compound:9076122|FD-Score:5.60|P-value:8.80E-7 ID:SGTC_3007|Compound:9078383|FD-Score:3.65|P-value:9.45E-4 ID:SGTC_3320|Compound:9137005|FD-Score:5.70|P-value:5.75E-7 ID:SGTC_111|Compound:0083-0039|FD-Score:-3.81|P-value:5.41E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.73|P-value:7.35E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.54|P-value:5.43E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.89|P-value:4.57E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-5.10|P-value:6.16E-6 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-4.21|P-value:1.55E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.65|P-value:9.47E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.30|P-value:1.15E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.26|P-value:1.41E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.61|P-value:9.75E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-4.22|P-value:1.47E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-4.11|P-value:2.12E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.86|P-value:1.69E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-4.71|P-value:2.76E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.24|P-value:1.53E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.00|P-value:1.02E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.94|P-value:3.67E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:6.78|P-value:3.67E-9 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.88|P-value:4.36E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.72|P-value:7.72E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.04|P-value:2.87E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.64|P-value:9.55E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.73|P-value:7.53E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.14|P-value:2.06E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-5.30|P-value:2.87E-6 ID:SGTC_2116|Compound:5511452|FD-Score:-5.04|P-value:7.78E-6 ID:SGTC_2166|Compound:5933061|FD-Score:4.20|P-value:1.74E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-3.93|P-value:3.83E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-5.99|P-value:1.48E-7 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.83|P-value:1.93E-5 ID:SGTC_2255|Compound:7941087|FD-Score:4.17|P-value:1.88E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.26|P-value:3.38E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.30|P-value:1.13E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.97|P-value:1.74E-7 ID:SGTC_2421|Compound:5690543|FD-Score:-4.22|P-value:1.48E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.17|P-value:1.77E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.70|P-value:7.63E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:5.51|P-value:1.32E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:4.08|P-value:2.51E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.96|P-value:3.65E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.70|P-value:3.13E-5 ID:SGTC_2871|Compound:9038510|FD-Score:-5.11|P-value:6.11E-6 ID:SGTC_2880|Compound:9042983|FD-Score:-4.69|P-value:2.95E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.80|P-value:6.01E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.72|P-value:7.14E-4 ID:SGTC_2902|Compound:5787006|FD-Score:8.58|P-value:1.20E-13 ID:SGTC_2904|Compound:7225135|FD-Score:-5.31|P-value:2.73E-6 ID:SGTC_2912|Compound:7964298|FD-Score:6.74|P-value:4.55E-9 ID:SGTC_2915|Compound:7971052|FD-Score:5.80|P-value:3.73E-7 ID:SGTC_3004|Compound:9076122|FD-Score:5.60|P-value:8.80E-7 ID:SGTC_3007|Compound:9078383|FD-Score:3.65|P-value:9.45E-4 ID:SGTC_3320|Compound:9137005|FD-Score:5.70|P-value:5.75E-7

Top fitness defect scores for YNL133C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2902 5787006 8.58 60.5 µM 1.20E-13 Golgi 1 4.64E-18
2 SGTC_936 3005-4620 6.78 401.0 µM 3.67E-9 2 6.05E-12
3 SGTC_2912 7964298 6.74 10.9 µM 4.55E-9 cell wall 36 8.12E-12
4 SGTC_2413 inermin 5.97 26.1 µM 1.74E-7 19 1.15E-9
5 SGTC_2915 7971052 5.80 15.2 µM 3.73E-7 2 3.26E-9
6 SGTC_3320 9137005 5.70 35.1 µM 5.75E-7 endomembrane recycling 3 5.86E-9
7 SGTC_3004 9076122 5.60 71.4 µM 8.80E-7 5 1.05E-8
8 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 5.51 15.3 µM 1.32E-6 11 1.82E-8
9 SGTC_926 2268-1401 5.00 59.4 µM 1.02E-5 TSC3-RPN4 16 2.91E-7
10 SGTC_740 k014-0057 4.86 261.0 µM 1.69E-5 9 5.75E-7
11 SGTC_2251 lansoprazole 4.83 556.0 µM 1.93E-5 9 6.89E-7
12 SGTC_2844 9010103 4.70 26.0 µM 3.13E-5 14 1.33E-6
13 SGTC_355 1311-2252 4.54 105.0 µM 5.43E-5 10 2.80E-6
14 SGTC_576 1073-0113 4.26 22.7 µM 1.41E-4 redox potentiating 54 1.02E-5
15 SGTC_832 4083-0019 4.24 164.0 µM 1.53E-4 translation 75 1.14E-5
16 SGTC_2166 5933061 4.20 31.5 µM 1.74E-4 tubulin folding & SWR complex 31 1.35E-5
17 SGTC_2255 7941087 4.17 197.4 µM 1.88E-4 25 1.50E-5
18 SGTC_1916 st067606 4.14 49.2 µM 2.06E-4 31 1.70E-5
19 SGTC_2606 farnesol 4.08 9.8 µM 2.51E-4 17 2.22E-5
20 SGTC_1496 4469-0713 4.04 57.4 µM 2.87E-4 16 2.66E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.06E-15 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.105 1.21E-9 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.096 2.23E-8 YPL254W HFI1 hom Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
0.095 3.82E-8 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.088 3.24E-7 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.081 2.93E-6 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.079 5.25E-6 YDL109C_p YDL109C_p hom Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
0.078 5.80E-6 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.075 1.38E-5 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.074 1.65E-5 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.074 1.81E-5 YDR389W SAC7 hom GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.074 1.87E-5 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.074 1.99E-5 YDR425W SNX41 hom Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p
0.073 2.10E-5 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.072 2.83E-5 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence