Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
Profile for YNL134C / YNL134C

Click on Significant Values for Screen Details

Top fitness defect scores for YNL134C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_87 0100-0052 9.22 35.5 µM 2.79E-25 8 1.51E-20
2 SGTC_686 1319-0111 4.68 510.0 µM 7.96E-8 60S ribosome export 15 1.40E-6
3 SGTC_3207 9114163 4.12 49.5 µM 2.00E-6 26 1.88E-5
4 SGTC_938 3126-1755 4.05 342.0 µM 2.95E-6 11 2.56E-5
5 SGTC_349 k015-0014 3.70 24.0 µM 1.77E-5 25 1.09E-4
6 SGTC_416 estradiol valerate 3.64 100.0 µM 2.29E-5 21 1.34E-4
7 SGTC_2965 9082772 3.36 38.6 µM 8.76E-5 mitochondrial response to ROS 57 3.95E-4
8 SGTC_2208 7283366 3.25 200.0 µM 1.42E-4 21 5.84E-4
9 SGTC_1401 3807-4679 3.14 7.6 µM 2.25E-4 tubulin folding & SWR complex 40 8.48E-4
10 SGTC_674 0498-0004 3.09 451.0 µM 2.74E-4 heme requiring 54 9.96E-4
11 SGTC_151 3013-0144 2.95 2.3 µM 4.79E-4 iron homeostasis 80 0.00157
12 SGTC_401 neomycin 2.92 50.0 µM 5.45E-4 43 0.00174
13 SGTC_438 sphingosine 2.88 6.7 µM 6.33E-4 72 0.00196
14 SGTC_1235 benzylparaben 2.85 21.5 µM 7.14E-4 56 0.00216
15 SGTC_3201 9113999 2.75 49.5 µM 0.00104 101 0.00294
16 SGTC_1043 0916-0009 2.71 19.3 µM 0.00124 103 0.00339
17 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 2.68 100.0 µM 0.00138 60S ribosome export 95 0.00369
18 SGTC_2162 5663267 2.66 200.0 µM 0.00146 67 0.00387
19 SGTC_1698 5-fluorocytosine 2.65 1.1 µM 0.00152 exosome 65 0.00400
20 SGTC_1061 3448-9325 2.63 110.0 µM 0.00162 90 0.00421

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 6.35E-31 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.193 2.23E-29 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.174 3.50E-24 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.143 8.47E-17 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.132 1.42E-14 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.129 5.32E-14 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.128 1.06E-13 YDL009C_p YDL009C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene
0.124 5.58E-13 YCL063W VAC17 hom Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p
0.119 4.31E-12 YPR153W YPR153W hom Putative protein of unknown function
0.112 6.75E-11 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.112 6.96E-11 YOR066W MSA1 hom Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.110 1.62E-10 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.108 3.72E-10 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.108 4.09E-10 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.107 5.57E-10 YGR115C_d YGR115C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C