YNL136W / EAF7

Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL136W / EAF7

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.21|P-value:2.36E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:3.65|P-value:6.58E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.57|P-value:3.94E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:3.71|P-value:5.43E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.28|P-value:1.70E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.81|P-value:3.99E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:9.22|P-value:2.73E-16 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.56|P-value:9.47E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.68|P-value:2.97E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.69|P-value:6.39E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-4.62|P-value:2.75E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.24|P-value:9.37E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.64|P-value:2.27E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:4.26|P-value:8.84E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.62|P-value:2.42E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.05|P-value:1.84E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.84|P-value:3.57E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.89|P-value:3.10E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.15|P-value:3.20E-8 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.47|P-value:4.68E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.43|P-value:4.78E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.92|P-value:2.80E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.57|P-value:9.09E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.25|P-value:1.97E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:4.74|P-value:1.53E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:5.50|P-value:6.63E-7 ID:SGTC_934|Compound:2950-0684|FD-Score:-4.23|P-value:1.10E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:5.66|P-value:3.29E-7 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.83|P-value:1.09E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.59|P-value:7.89E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:10.80|P-value:8.46E-22 ID:SGTC_1383|Compound:3049-0032|FD-Score:-4.17|P-value:1.34E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.86|P-value:3.71E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.04|P-value:1.91E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.84|P-value:1.04E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.25|P-value:9.06E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.64|P-value:6.80E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.95|P-value:2.51E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.78|P-value:1.31E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.81|P-value:3.96E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.81|P-value:1.15E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.24|P-value:2.04E-6 ID:SGTC_1848|Compound:st056003|FD-Score:4.13|P-value:1.38E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.04|P-value:1.90E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.79|P-value:4.21E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.69|P-value:5.80E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.60|P-value:7.65E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.78|P-value:1.29E-5 ID:SGTC_2132|Compound:5317594|FD-Score:4.61|P-value:2.46E-5 ID:SGTC_2396|Compound:5342950|FD-Score:5.34|P-value:1.31E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.56|P-value:8.59E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.98|P-value:2.57E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:6.18|P-value:2.80E-8 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:6.39|P-value:9.84E-9 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.33|P-value:7.91E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.87|P-value:1.23E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.92|P-value:2.76E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.97|P-value:2.38E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.95|P-value:2.55E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.15|P-value:1.28E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.67|P-value:6.24E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.11|P-value:1.51E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.23|P-value:9.72E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.51|P-value:9.93E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-5.27|P-value:2.03E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.55|P-value:8.78E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.78|P-value:4.83E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.17|P-value:1.37E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.20|P-value:1.09E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.21|P-value:2.36E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:3.65|P-value:6.58E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.57|P-value:3.94E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:3.71|P-value:5.43E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.28|P-value:1.70E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.81|P-value:3.99E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:9.22|P-value:2.73E-16 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.56|P-value:9.47E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.68|P-value:2.97E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.69|P-value:6.39E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-4.62|P-value:2.75E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.24|P-value:9.37E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.64|P-value:2.27E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:4.26|P-value:8.84E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.62|P-value:2.42E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.05|P-value:1.84E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.84|P-value:3.57E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.89|P-value:3.10E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.15|P-value:3.20E-8 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.47|P-value:4.68E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.43|P-value:4.78E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.92|P-value:2.80E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.57|P-value:9.09E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.25|P-value:1.97E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:4.74|P-value:1.53E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:5.50|P-value:6.63E-7 ID:SGTC_934|Compound:2950-0684|FD-Score:-4.23|P-value:1.10E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:5.66|P-value:3.29E-7 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.83|P-value:1.09E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.59|P-value:7.89E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:10.80|P-value:8.46E-22 ID:SGTC_1383|Compound:3049-0032|FD-Score:-4.17|P-value:1.34E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.86|P-value:3.71E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.04|P-value:1.91E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.84|P-value:1.04E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.25|P-value:9.06E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.64|P-value:6.80E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.95|P-value:2.51E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.78|P-value:1.31E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.81|P-value:3.96E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.81|P-value:1.15E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.24|P-value:2.04E-6 ID:SGTC_1848|Compound:st056003|FD-Score:4.13|P-value:1.38E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.04|P-value:1.90E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.79|P-value:4.21E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.69|P-value:5.80E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.60|P-value:7.65E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.78|P-value:1.29E-5 ID:SGTC_2132|Compound:5317594|FD-Score:4.61|P-value:2.46E-5 ID:SGTC_2396|Compound:5342950|FD-Score:5.34|P-value:1.31E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.56|P-value:8.59E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.98|P-value:2.57E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:6.18|P-value:2.80E-8 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:6.39|P-value:9.84E-9 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-4.33|P-value:7.91E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.87|P-value:1.23E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.92|P-value:2.76E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.97|P-value:2.38E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.95|P-value:2.55E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.15|P-value:1.28E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.67|P-value:6.24E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.11|P-value:1.51E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.23|P-value:9.72E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.51|P-value:9.93E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-5.27|P-value:2.03E-6 ID:SGTC_3138|Compound:9097216|FD-Score:3.55|P-value:8.78E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.78|P-value:4.83E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.17|P-value:1.37E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.20|P-value:1.09E-4

Top fitness defect scores for YNL136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1294 1000-1494 10.80 117.0 µM 8.46E-22 11 1.04E-27
2 SGTC_107 0358-0022 9.22 2.7 µM 2.73E-16 SWF1 & branched chain AA biosynthesis 8 1.43E-20
3 SGTC_46 0329-0187a 6.57 2.2 µM 3.94E-9 25 2.57E-11
4 SGTC_2506 ethyl hematommate 6.39 54.2 µM 9.84E-9 RPP1 & pyrimidine depletion 2 8.37E-11
5 SGTC_36 0335-0881 6.21 14.2 µM 2.36E-8 ubiquinone biosynthesis & proteasome 61 2.59E-10
6 SGTC_2497 7-hydroxyflavone 6.18 100.0 µM 2.80E-8 3 3.22E-10
7 SGTC_351 caspofungin 6.15 25.0 nM 3.20E-8 cell wall 37 3.83E-10
8 SGTC_2582 agaric acid 5.87 100.0 µM 1.23E-7 redox potentiating 165 2.17E-9
9 SGTC_117 lucigenin 5.68 22.1 µM 2.97E-7 redox potentiating 42 6.75E-9
10 SGTC_984 1492-0255 5.66 2.9 µM 3.29E-7 SWF1 & branched chain AA biosynthesis 12 7.69E-9
11 SGTC_922 1866-0035 5.50 480.0 µM 6.63E-7 excess fatty acid 24 1.90E-8
12 SGTC_2396 5342950 5.34 42.8 µM 1.31E-6 RSC complex & mRNA processing 18 4.56E-8
13 SGTC_86 0417-1630 5.28 471.9 µM 1.70E-6 ubiquinone biosynthesis & proteasome 105 6.38E-8
14 SGTC_794 k038-0031 5.25 316.0 µM 1.97E-6 ubiquinone biosynthesis & proteasome 77 7.70E-8
15 SGTC_1750 st081859 5.24 2.4 µM 2.04E-6 endomembrane recycling 128 8.06E-8
16 SGTC_1504 k297-0033 4.84 30.0 µM 1.04E-5 4 6.55E-7
17 SGTC_1111 tnp00062 4.83 510.7 nM 1.09E-5 3 6.91E-7
18 SGTC_1679 4130-1276 4.81 6.7 µM 1.15E-5 Golgi 40 7.40E-7
19 SGTC_2111 5486399 4.78 200.0 µM 1.29E-5 20 8.59E-7
20 SGTC_1635 st007035 4.78 42.4 µM 1.31E-5 176 8.77E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.416 2.46E-140 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.407 2.15E-134 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.397 9.56E-127 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.381 4.23E-116 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.378 4.58E-114 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.371 5.79E-110 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.360 3.79E-103 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.353 2.19E-99 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.347 1.12E-95 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.309 5.27E-75 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.300 1.07E-70 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.276 1.10E-59 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.261 2.39E-53 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.257 1.11E-51 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.256 3.01E-51 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication