YNL137C / NAM9

Mitochondrial ribosomal component of the small subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL137C / NAM9

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.78|P-value:4.89E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.08|P-value:9.40E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.45|P-value:1.57E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:3.85|P-value:4.77E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:3.06|P-value:9.99E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:2.28E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.27|P-value:3.64E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.21|P-value:5.79E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.82|P-value:5.43E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.40|P-value:4.03E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.11|P-value:8.35E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.30|P-value:4.19E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.86|P-value:3.43E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.35|P-value:3.49E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:-3.19|P-value:4.90E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.14|P-value:9.20E-8 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.44|P-value:2.52E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.93|P-value:2.84E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.07|P-value:7.41E-4 ID:SGTC_1647|Compound:st011722|FD-Score:5.01|P-value:1.83E-7 ID:SGTC_1694|Compound:st024011|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.10|P-value:8.53E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.16|P-value:6.95E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.16|P-value:6.95E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.16|P-value:1.24E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.06|P-value:9.86E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.52|P-value:2.25E-6 ID:SGTC_2010|Compound:4012422|FD-Score:9.95|P-value:1.98E-24 ID:SGTC_2011|Compound:4012611|FD-Score:-5.37|P-value:1.64E-8 ID:SGTC_2135|Compound:5326629|FD-Score:-4.04|P-value:1.56E-5 ID:SGTC_2162|Compound:5663267|FD-Score:-3.24|P-value:4.07E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.22|P-value:4.39E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.38|P-value:2.41E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.26|P-value:3.81E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.03|P-value:8.58E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.53|P-value:2.16E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_2700|Compound:st077718|FD-Score:6.06|P-value:3.77E-10 ID:SGTC_2717|Compound:st081029|FD-Score:4.69|P-value:9.65E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.74|P-value:7.72E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.51|P-value:1.91E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.12|P-value:8.15E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.29|P-value:4.48E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.78|P-value:4.89E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.08|P-value:9.40E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.45|P-value:1.57E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:3.85|P-value:4.77E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:3.06|P-value:9.99E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:2.28E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.27|P-value:3.64E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.21|P-value:5.79E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.82|P-value:5.43E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.40|P-value:4.03E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.11|P-value:8.35E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.30|P-value:4.19E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.86|P-value:3.43E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.35|P-value:3.49E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:-3.19|P-value:4.90E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.14|P-value:9.20E-8 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.44|P-value:2.52E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.93|P-value:2.84E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.07|P-value:7.41E-4 ID:SGTC_1647|Compound:st011722|FD-Score:5.01|P-value:1.83E-7 ID:SGTC_1694|Compound:st024011|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.10|P-value:8.53E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.16|P-value:6.95E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.16|P-value:6.95E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.16|P-value:1.24E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.06|P-value:9.86E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.52|P-value:2.25E-6 ID:SGTC_2010|Compound:4012422|FD-Score:9.95|P-value:1.98E-24 ID:SGTC_2011|Compound:4012611|FD-Score:-5.37|P-value:1.64E-8 ID:SGTC_2135|Compound:5326629|FD-Score:-4.04|P-value:1.56E-5 ID:SGTC_2162|Compound:5663267|FD-Score:-3.24|P-value:4.07E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.22|P-value:4.39E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.38|P-value:2.41E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.26|P-value:3.81E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.03|P-value:8.58E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.53|P-value:2.16E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_2700|Compound:st077718|FD-Score:6.06|P-value:3.77E-10 ID:SGTC_2717|Compound:st081029|FD-Score:4.69|P-value:9.65E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.74|P-value:7.72E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.51|P-value:1.91E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.12|P-value:8.15E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.29|P-value:4.48E-4

Top fitness defect scores for YNL137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2010 4012422 9.95 159.0 µM 1.98E-24 1 1.26E-23 3.29
2 SGTC_2700 st077718 6.06 96.8 µM 3.77E-10 1 6.91E-10 0.78
3 SGTC_120 rhodamine 6G 5.45 52.3 µM 1.57E-8 mitochondrial processes 7 2.52E-8 0.22
4 SGTC_1279 0874-0590 5.14 65.2 µM 9.20E-8 2 1.39E-7 1.00
5 SGTC_1647 st011722 5.01 22.4 µM 1.83E-7 1 2.69E-7 0.43
6 SGTC_1351 1496-0003 4.93 46.5 µM 2.84E-7 2 4.12E-7 0.76
7 SGTC_2717 st081029 4.69 62.3 µM 9.65E-7 1 1.34E-6 0.70
8 SGTC_2566 crystal violet carbinol 4.53 226.0 nM 2.16E-6 8 2.92E-6 0.04
9 SGTC_2004 4023728 4.52 41.9 µM 2.25E-6 20 3.05E-6 0.01
10 SGTC_1002 4049-0206 4.40 172.0 µM 4.03E-6 2 5.34E-6 0.09
11 SGTC_1919 st067113 4.16 52.3 µM 1.24E-5 TSC3-RPN4 9 1.58E-5 0.10
12 SGTC_149 3970-0822 3.85 46.1 µM 4.77E-5 tubulin folding & SWR complex 11 5.82E-5 0.06
13 SGTC_994 3910-0338 3.82 138.0 µM 5.43E-5 calcium & mitochondrial duress 14 6.60E-5 0.04
14 SGTC_2771 fluoxetine 3.74 41.0 µM 7.72E-5 3 9.28E-5 0.29
15 SGTC_1694 st024011 3.60 44.9 µM 1.37E-4 ERG2 11 1.62E-4 0.09
16 SGTC_2910 7948405 3.51 26.0 µM 1.91E-4 plasma membrane duress 5 2.23E-4 0.14
17 SGTC_474 dl-dihydrosphingosine 3.47 5.0 µM 2.28E-4 11 2.65E-4 0.02
18 SGTC_1314 1222-0010 3.44 41.1 µM 2.52E-4 5 2.92E-4 0.17
19 SGTC_1176 0848-0131 3.35 83.3 µM 3.49E-4 Golgi 8 4.00E-4 0.11
20 SGTC_2576 guaiol 3.34 23.1 µM 3.71E-4 17 4.25E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.90E-13 YIL016W SNL1 hom Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
0.105 1.25E-9 YKL133C_p YKL133C_p hom Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)
0.101 5.34E-9 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.099 9.50E-9 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.095 3.70E-8 YJL190C RPS22A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
0.095 4.03E-8 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.091 1.30E-7 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.090 1.61E-7 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.089 2.20E-7 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.088 3.12E-7 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.083 1.50E-6 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.082 2.14E-6 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.081 2.80E-6 YLR041W_d YLR041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
0.081 2.96E-6 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.081 2.96E-6 YJR021C REC107 hom Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation