YNL139C / THO2

Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL139C / THO2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.23|P-value:4.99E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.42|P-value:3.96E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-3.54|P-value:5.39E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:5.20|P-value:1.66E-6 ID:SGTC_263|Compound:alizarin|FD-Score:-3.45|P-value:7.20E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.95|P-value:2.77E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.26|P-value:4.49E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.73|P-value:4.56E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.69|P-value:1.39E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:5.10|P-value:2.48E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:3.53|P-value:8.46E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.89|P-value:1.72E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.62|P-value:6.37E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.48|P-value:6.53E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.67|P-value:3.59E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:6.15|P-value:1.74E-8 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.51|P-value:6.04E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-4.82|P-value:4.85E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:5.33|P-value:9.22E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.34|P-value:8.63E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.58|P-value:4.77E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.58|P-value:2.14E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.61|P-value:2.53E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.21|P-value:8.78E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.84|P-value:3.10E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.36|P-value:4.90E-5 ID:SGTC_1728|Compound:st035614|FD-Score:5.00|P-value:3.83E-6 ID:SGTC_1772|Compound:st048439|FD-Score:4.50|P-value:2.91E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.50|P-value:9.36E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.52|P-value:8.62E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.10|P-value:1.29E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.23|P-value:8.14E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.96|P-value:1.33E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.60|P-value:2.62E-7 ID:SGTC_2007|Compound:4011539|FD-Score:3.81|P-value:3.48E-4 ID:SGTC_2163|Compound:5671233|FD-Score:5.25|P-value:1.30E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.57|P-value:2.23E-5 ID:SGTC_2259|Compound:7964009|FD-Score:-4.02|P-value:1.10E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.73|P-value:4.50E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.54|P-value:8.14E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.96|P-value:4.57E-8 ID:SGTC_2495|Compound:cafestol|FD-Score:3.89|P-value:2.64E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.58|P-value:2.12E-5 ID:SGTC_2867|Compound:9039098|FD-Score:3.67|P-value:5.46E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.75|P-value:4.21E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.72|P-value:4.66E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.70|P-value:4.99E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.47|P-value:6.76E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.26|P-value:7.25E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.21|P-value:8.53E-5 ID:SGTC_3307|Compound:9126885|FD-Score:4.70|P-value:1.33E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-3.61|P-value:4.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.23|P-value:4.99E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.42|P-value:3.96E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-3.54|P-value:5.39E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:5.20|P-value:1.66E-6 ID:SGTC_263|Compound:alizarin|FD-Score:-3.45|P-value:7.20E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.95|P-value:2.77E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.26|P-value:4.49E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.73|P-value:4.56E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.69|P-value:1.39E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:5.10|P-value:2.48E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:3.53|P-value:8.46E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.89|P-value:1.72E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.62|P-value:6.37E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.48|P-value:6.53E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.67|P-value:3.59E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:6.15|P-value:1.74E-8 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.51|P-value:6.04E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-4.82|P-value:4.85E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:5.33|P-value:9.22E-7 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.34|P-value:8.63E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.58|P-value:4.77E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.58|P-value:2.14E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.61|P-value:2.53E-7 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.21|P-value:8.78E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.84|P-value:3.10E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.36|P-value:4.90E-5 ID:SGTC_1728|Compound:st035614|FD-Score:5.00|P-value:3.83E-6 ID:SGTC_1772|Compound:st048439|FD-Score:4.50|P-value:2.91E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.50|P-value:9.36E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.52|P-value:8.62E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.10|P-value:1.29E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.23|P-value:8.14E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.96|P-value:1.33E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.60|P-value:2.62E-7 ID:SGTC_2007|Compound:4011539|FD-Score:3.81|P-value:3.48E-4 ID:SGTC_2163|Compound:5671233|FD-Score:5.25|P-value:1.30E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.57|P-value:2.23E-5 ID:SGTC_2259|Compound:7964009|FD-Score:-4.02|P-value:1.10E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.73|P-value:4.50E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.54|P-value:8.14E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.96|P-value:4.57E-8 ID:SGTC_2495|Compound:cafestol|FD-Score:3.89|P-value:2.64E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.58|P-value:2.12E-5 ID:SGTC_2867|Compound:9039098|FD-Score:3.67|P-value:5.46E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.75|P-value:4.21E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.72|P-value:4.66E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.70|P-value:4.99E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.47|P-value:6.76E-4 ID:SGTC_3299|Compound:9121982|FD-Score:4.26|P-value:7.25E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.21|P-value:8.53E-5 ID:SGTC_3307|Compound:9126885|FD-Score:4.70|P-value:1.33E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-3.61|P-value:4.42E-4

Top fitness defect scores for YNL139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_924 2046-0044 6.15 21.3 µM 1.74E-8 2 3.83E-10
2 SGTC_2396 5342950 5.96 42.8 µM 4.57E-8 RSC complex & mRNA processing 14 1.24E-9
3 SGTC_1157 4092-0394 5.61 27.6 µM 2.53E-7 7 1.01E-8
4 SGTC_1965 Pectolinarigenin 5.60 58.4 µM 2.62E-7 RPP1 & pyrimidine depletion 2 1.05E-8
5 SGTC_1122 capsaicin 5.34 818.6 nM 8.63E-7 9 4.55E-8
6 SGTC_940 3232-1287 5.33 54.8 µM 9.22E-7 NEO1 12 4.93E-8
7 SGTC_2163 5671233 5.25 125.0 µM 1.30E-6 8 7.52E-8
8 SGTC_174 3553-0389 5.20 74.3 µM 1.66E-6 6 1.01E-7
9 SGTC_367 0335-0881 5.10 7.1 µM 2.48E-6 ubiquinone biosynthesis & proteasome 39 1.65E-7
10 SGTC_1728 st035614 5.00 33.8 µM 3.83E-6 23 2.82E-7
11 SGTC_3307 9126885 4.70 69.3 µM 1.33E-5 19 1.29E-6
12 SGTC_366 0181-0206 4.69 4.3 µM 1.39E-5 Golgi 20 1.36E-6
13 SGTC_2845 9003024 4.58 43.0 µM 2.12E-5 amide catabolism 29 2.28E-6
14 SGTC_1135 dihydrocapsaicin 4.58 536.7 nM 2.14E-5 20 2.31E-6
15 SGTC_2254 7938975 4.57 95.2 µM 2.23E-5 36 2.43E-6
16 SGTC_1772 st048439 4.50 82.2 µM 2.91E-5 24 3.37E-6
17 SGTC_43 0570-0105 4.42 72.5 µM 3.96E-5 ERG2 77 4.92E-6
18 SGTC_1726 st035556 4.36 14.6 µM 4.90E-5 25 6.37E-6
19 SGTC_3299 9121982 4.26 43.1 µM 7.25E-5 19 1.03E-5
20 SGTC_1803 st050068 4.23 52.4 µM 8.14E-5 NEO1-PIK1 160 1.19E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 4.94E-22 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.158 3.83E-20 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.140 3.51E-16 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.134 7.85E-15 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.132 2.12E-14 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.121 2.29E-12 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.119 4.64E-12 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.119 5.18E-12 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.25E-10 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.108 4.21E-10 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.106 6.17E-10 YDR138W HPR1 hom Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
0.106 6.21E-10 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 8.79E-10 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.105 1.10E-9 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.103 2.04E-9 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases