YNL140C_p

Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL140C / YNL140C

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.78|P-value:3.98E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:11.70|P-value:1.02E-28 ID:SGTC_59|Compound:0330-0160|FD-Score:4.00|P-value:9.70E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.56|P-value:4.74E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.33|P-value:2.71E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.67|P-value:6.41E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:8.17|P-value:6.09E-15 ID:SGTC_178|Compound:4092-0806|FD-Score:3.97|P-value:1.10E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.04|P-value:6.79E-9 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.61|P-value:8.08E-6 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.44|P-value:1.67E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.87|P-value:5.50E-14 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.77|P-value:3.08E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.37|P-value:2.30E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:5.98|P-value:9.83E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.38|P-value:8.77E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.96|P-value:3.22E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:5.58|P-value:8.28E-8 ID:SGTC_543|Compound:3844-1095|FD-Score:4.36|P-value:2.35E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:5.11|P-value:8.56E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:4.13|P-value:5.85E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.36|P-value:2.35E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:13.50|P-value:7.69E-38 ID:SGTC_658|Compound:3253-0951|FD-Score:6.07|P-value:5.75E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.42|P-value:7.33E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:3.49|P-value:5.99E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.19|P-value:7.91E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.66|P-value:1.58E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.11|P-value:2.67E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.50|P-value:2.80E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.24|P-value:6.78E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:5.67|P-value:5.08E-8 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.80|P-value:2.06E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.47|P-value:3.09E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.93|P-value:1.29E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.94|P-value:1.87E-6 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.62|P-value:3.85E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.66|P-value:3.40E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.00|P-value:4.24E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.93|P-value:1.25E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.50|P-value:2.79E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.99|P-value:1.03E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.24|P-value:6.86E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.93|P-value:1.27E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.14|P-value:5.61E-5 ID:SGTC_2080|Compound:5212524|FD-Score:4.09|P-value:6.98E-5 ID:SGTC_2081|Compound:5214970|FD-Score:4.40|P-value:2.00E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.23|P-value:4.01E-5 ID:SGTC_2284|Compound:7945075|FD-Score:4.97|P-value:1.63E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.37|P-value:2.31E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.23|P-value:4.03E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.23|P-value:7.03E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:-3.24|P-value:6.82E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.22|P-value:7.22E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.83|P-value:8.27E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.84|P-value:7.85E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.39|P-value:8.54E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-6.18|P-value:8.69E-10 ID:SGTC_2866|Compound:9034245|FD-Score:3.58|P-value:4.51E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.72|P-value:2.75E-4 ID:SGTC_3148|Compound:9097893|FD-Score:6.89|P-value:4.20E-11 ID:SGTC_3337|Compound:9144342|FD-Score:8.68|P-value:1.14E-16 ID:SGTC_14|Compound:0354-0009|FD-Score:4.78|P-value:3.98E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:11.70|P-value:1.02E-28 ID:SGTC_59|Compound:0330-0160|FD-Score:4.00|P-value:9.70E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.56|P-value:4.74E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.33|P-value:2.71E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.67|P-value:6.41E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:8.17|P-value:6.09E-15 ID:SGTC_178|Compound:4092-0806|FD-Score:3.97|P-value:1.10E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:6.04|P-value:6.79E-9 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.61|P-value:8.08E-6 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.44|P-value:1.67E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.87|P-value:5.50E-14 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.77|P-value:3.08E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.37|P-value:2.30E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:5.98|P-value:9.83E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.38|P-value:8.77E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.96|P-value:3.22E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:5.58|P-value:8.28E-8 ID:SGTC_543|Compound:3844-1095|FD-Score:4.36|P-value:2.35E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:5.11|P-value:8.56E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:4.13|P-value:5.85E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.36|P-value:2.35E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:13.50|P-value:7.69E-38 ID:SGTC_658|Compound:3253-0951|FD-Score:6.07|P-value:5.75E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.42|P-value:7.33E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:3.49|P-value:5.99E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.19|P-value:7.91E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.66|P-value:1.58E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.11|P-value:2.67E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.50|P-value:2.80E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.24|P-value:6.78E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:5.67|P-value:5.08E-8 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.80|P-value:2.06E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.47|P-value:3.09E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.93|P-value:1.29E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.94|P-value:1.87E-6 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.62|P-value:3.85E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.66|P-value:3.40E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-4.00|P-value:4.24E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.93|P-value:1.25E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.50|P-value:2.79E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.99|P-value:1.03E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.24|P-value:6.86E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.93|P-value:1.27E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.14|P-value:5.61E-5 ID:SGTC_2080|Compound:5212524|FD-Score:4.09|P-value:6.98E-5 ID:SGTC_2081|Compound:5214970|FD-Score:4.40|P-value:2.00E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.23|P-value:4.01E-5 ID:SGTC_2284|Compound:7945075|FD-Score:4.97|P-value:1.63E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.37|P-value:2.31E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.23|P-value:4.03E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:-3.23|P-value:7.03E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:-3.24|P-value:6.82E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.22|P-value:7.22E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.83|P-value:8.27E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.84|P-value:7.85E-5 ID:SGTC_2793|Compound:7325131|FD-Score:3.39|P-value:8.54E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-6.18|P-value:8.69E-10 ID:SGTC_2866|Compound:9034245|FD-Score:3.58|P-value:4.51E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.72|P-value:2.75E-4 ID:SGTC_3148|Compound:9097893|FD-Score:6.89|P-value:4.20E-11 ID:SGTC_3337|Compound:9144342|FD-Score:8.68|P-value:1.14E-16

Top fitness defect scores for YNL140C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_617 3770-0098 13.50 35.0 µM 7.69E-38 exosome 1 9.08E-42
2 SGTC_43 0570-0105 11.70 72.5 µM 1.02E-28 ERG2 7 9.99E-32
3 SGTC_3337 9144342 8.68 33.5 µM 1.14E-16 7 1.93E-18
4 SGTC_161 4065-0411 8.17 162.2 µM 6.09E-15 13 1.55E-16
5 SGTC_241 5hr heat shock (37°C) + cantharidin 7.87 155.4 µM 5.50E-14 cell wall signaling 18 1.77E-15
6 SGTC_3148 9097893 6.89 49.5 µM 4.20E-11 10 2.72E-12
7 SGTC_658 3253-0951 6.07 102.0 µM 5.75E-9 calcium & mitochondrial duress 17 6.32E-10
8 SGTC_238 5hr heat shock (37°C) + nsc-638432 6.04 8.9 µM 6.79E-9 heat shock/prefoldin 16 7.60E-10
9 SGTC_427 1354-0053 5.98 47.3 µM 9.83E-9 3 1.15E-9
10 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.77 4.6 µM 3.08E-8 heat shock/prefoldin 15 4.07E-9
11 SGTC_1372 2752-0194 5.67 270.0 µM 5.08E-8 5 7.08E-9
12 SGTC_528 3492-0019 5.58 172.0 µM 8.28E-8 calcium & mitochondrial duress 134 1.22E-8
13 SGTC_240 5hr heat shock (37°C) + Streptovitacin 5.44 300.0 µM 1.67E-7 heat shock/prefoldin 23 2.64E-8
14 SGTC_562 3772-2733 5.11 112.0 µM 8.56E-7 ERG2 49 1.63E-7
15 SGTC_2284 7945075 4.97 39.2 µM 1.63E-6 mitochondrial processes 13 3.34E-7
16 SGTC_1846 st056244 4.94 14.8 µM 1.87E-6 11 3.88E-7
17 SGTC_14 0354-0009 4.78 295.0 µM 3.98E-6 14 8.98E-7
18 SGTC_146 3448-8650 4.67 53.1 µM 6.41E-6 NEO1-PIK1 102 1.52E-6
19 SGTC_239 5hr heat shock (37°C) + mitomycin C 4.61 819.4 µM 8.08E-6 heat shock/prefoldin 24 1.97E-6
20 SGTC_2081 5214970 4.40 32.3 µM 2.00E-5 16 5.39E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.309 4.47E-75 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.279 9.36E-61 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.246 1.23E-47 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.241 2.12E-45 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.217 3.42E-37 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.213 6.89E-36 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.209 1.64E-34 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.189 2.26E-28 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.172 1.30E-23 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.170 3.15E-23 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.170 3.35E-23 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.165 5.52E-22 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.165 5.89E-22 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.154 3.65E-19 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.153 5.14E-19 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA