YNL141W / AAH1

Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL141W / AAH1

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:-3.17|P-value:5.79E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.19|P-value:1.08E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.76|P-value:1.92E-9 ID:SGTC_188|Compound:3229-0966|FD-Score:3.69|P-value:9.13E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.92|P-value:3.47E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.36|P-value:3.33E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.37|P-value:3.16E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.33|P-value:3.27E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.70|P-value:8.83E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.09|P-value:7.62E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.47|P-value:2.16E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:5.00|P-value:1.89E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.69|P-value:9.30E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.16|P-value:6.93E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:6.90|P-value:1.15E-12 ID:SGTC_976|Compound:1348-1067|FD-Score:-4.90|P-value:2.77E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.30|P-value:6.42E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.41|P-value:3.86E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.72|P-value:6.89E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.93|P-value:3.36E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.08|P-value:8.02E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.32|P-value:3.38E-4 ID:SGTC_1731|Compound:st035964|FD-Score:5.12|P-value:9.98E-8 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.18|P-value:6.48E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.30|P-value:4.14E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.05|P-value:8.81E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.21|P-value:5.75E-4 ID:SGTC_1939|Compound:st074455|FD-Score:6.03|P-value:4.43E-10 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.13|P-value:7.61E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.28|P-value:4.50E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.36|P-value:2.88E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.59|P-value:1.36E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.10|P-value:8.50E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.11|P-value:8.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:6.92|P-value:9.83E-13 ID:SGTC_2404|Compound:5161160|FD-Score:4.13|P-value:1.37E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.46|P-value:2.31E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.25|P-value:5.03E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.05|P-value:9.87E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.47|P-value:2.17E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.07|P-value:9.38E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.51|P-value:1.87E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.67|P-value:8.44E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.17|P-value:5.79E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.19|P-value:1.08E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.76|P-value:1.92E-9 ID:SGTC_188|Compound:3229-0966|FD-Score:3.69|P-value:9.13E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.92|P-value:3.47E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.36|P-value:3.33E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.37|P-value:3.16E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.33|P-value:3.27E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.47|P-value:2.22E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.70|P-value:8.83E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.09|P-value:7.62E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.47|P-value:2.16E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:5.00|P-value:1.89E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.69|P-value:9.30E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.16|P-value:6.93E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:6.90|P-value:1.15E-12 ID:SGTC_976|Compound:1348-1067|FD-Score:-4.90|P-value:2.77E-7 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.30|P-value:6.42E-6 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.41|P-value:3.86E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.72|P-value:6.89E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.93|P-value:3.36E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.08|P-value:8.02E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.32|P-value:3.38E-4 ID:SGTC_1731|Compound:st035964|FD-Score:5.12|P-value:9.98E-8 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.18|P-value:6.48E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.30|P-value:4.14E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.05|P-value:8.81E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.21|P-value:5.75E-4 ID:SGTC_1939|Compound:st074455|FD-Score:6.03|P-value:4.43E-10 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.13|P-value:7.61E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.28|P-value:4.50E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.36|P-value:2.88E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.59|P-value:1.36E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.10|P-value:8.50E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.11|P-value:8.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:6.92|P-value:9.83E-13 ID:SGTC_2404|Compound:5161160|FD-Score:4.13|P-value:1.37E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.46|P-value:2.31E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.25|P-value:5.03E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.05|P-value:9.87E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.47|P-value:2.17E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.07|P-value:9.38E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.51|P-value:1.87E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.67|P-value:8.44E-5

Top fitness defect scores for YNL141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2290 7904846 6.92 200.0 µM 9.83E-13 2 2.19E-12
2 SGTC_953 1188-0045 6.90 9.7 µM 1.15E-12 60S ribosome export 2 2.54E-12
3 SGTC_1939 st074455 6.03 53.6 µM 4.43E-10 6 8.04E-10
4 SGTC_1731 st035964 5.12 63.0 µM 9.98E-8 9 1.52E-7
5 SGTC_877 0771-0151 5.00 33.1 µM 1.89E-7 6 2.81E-7
6 SGTC_1126 isoteolin 4.41 1.0 µM 3.86E-6 21 5.22E-6
7 SGTC_1022 4477-0945 4.30 21.3 µM 6.42E-6 15 8.54E-6
8 SGTC_150 3970-0969 4.19 77.2 µM 1.08E-5 55 1.41E-5
9 SGTC_2404 5161160 4.13 200.0 µM 1.37E-5 14 1.78E-5
10 SGTC_1305 1181-0477 3.93 144.0 µM 3.36E-5 15 4.24E-5
11 SGTC_192 3455-0609 3.92 60.9 µM 3.47E-5 12 4.38E-5
12 SGTC_605 1315-0399 3.70 119.0 µM 8.83E-5 Golgi 33 1.08E-4
13 SGTC_188 3229-0966 3.69 278.5 µM 9.13E-5 32 1.12E-4
14 SGTC_881 0833-0569 3.69 170.0 µM 9.30E-5 43 1.14E-4
15 SGTC_2815 7968870 3.60 71.4 µM 1.33E-4 35 1.61E-4
16 SGTC_2244 6635614 3.59 200.0 µM 1.36E-4 7 1.65E-4
17 SGTC_3139 9095020 3.51 49.5 µM 1.87E-4 18 2.25E-4
18 SGTC_786 4544-0069 3.47 423.0 µM 2.16E-4 50 2.58E-4
19 SGTC_3017 9080681 3.47 49.5 µM 2.17E-4 23 2.59E-4
20 SGTC_600 1495-0418 3.47 41.6 µM 2.22E-4 RPP1 & pyrimidine depletion 22 2.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.81E-14 YOL104C NDJ1 hom Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.110 1.72E-10 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.095 3.03E-8 YGL172W NUP49 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
0.092 8.29E-8 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.082 2.07E-6 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.081 2.89E-6 YDL051W LHP1 hom RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
0.079 4.24E-6 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.078 5.46E-6 YBL011W SCT1 hom Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
0.076 9.42E-6 YDL160C-A MHF2 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
0.076 1.07E-5 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.075 1.33E-5 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.074 1.88E-5 YHR196W UTP9 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.074 2.01E-5 YNL243W SLA2 hom Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
0.071 3.97E-5 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.070 4.61E-5 YLR090W XDJ1 hom Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies