YNL143C_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL143C / YNL143C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.43|P-value:7.45E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.89|P-value:3.08E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:5.37|P-value:3.38E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.38|P-value:8.70E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-4.15|P-value:6.04E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-5.54|P-value:1.45E-7 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.68|P-value:3.27E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.77|P-value:2.42E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.10|P-value:7.51E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.35|P-value:9.77E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.41|P-value:8.01E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.51|P-value:1.53E-5 ID:SGTC_2020|Compound:4017018|FD-Score:4.16|P-value:6.01E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-4.28|P-value:3.68E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.38|P-value:8.67E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.65|P-value:3.66E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.41|P-value:7.93E-4 ID:SGTC_2390|Compound:9097792|FD-Score:4.77|P-value:5.10E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:4.47|P-value:1.79E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.55|P-value:5.00E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.45|P-value:6.92E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.72|P-value:6.17E-6 ID:SGTC_2810|Compound:7959871|FD-Score:3.61|P-value:4.21E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.45|P-value:7.09E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.99|P-value:1.10E-4 ID:SGTC_2869|Compound:9037858|FD-Score:5.65|P-value:8.75E-8 ID:SGTC_2878|Compound:9043973|FD-Score:4.37|P-value:2.63E-5 ID:SGTC_2879|Compound:9041815|FD-Score:-4.55|P-value:1.26E-5 ID:SGTC_2895|Compound:9054447|FD-Score:3.57|P-value:4.75E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-5.33|P-value:3.99E-7 ID:SGTC_3220|Compound:9131269|FD-Score:3.49|P-value:6.29E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.01|P-value:1.04E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.43|P-value:7.45E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.89|P-value:3.08E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:5.37|P-value:3.38E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.38|P-value:8.70E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-4.15|P-value:6.04E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-5.54|P-value:1.45E-7 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.68|P-value:3.27E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.77|P-value:2.42E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.10|P-value:7.51E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.35|P-value:9.77E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.41|P-value:8.01E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.51|P-value:1.53E-5 ID:SGTC_2020|Compound:4017018|FD-Score:4.16|P-value:6.01E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-4.28|P-value:3.68E-5 ID:SGTC_2307|Compound:7538926|FD-Score:-3.38|P-value:8.67E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.65|P-value:3.66E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.41|P-value:7.93E-4 ID:SGTC_2390|Compound:9097792|FD-Score:4.77|P-value:5.10E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:4.47|P-value:1.79E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.55|P-value:5.00E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.45|P-value:6.92E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-4.72|P-value:6.17E-6 ID:SGTC_2810|Compound:7959871|FD-Score:3.61|P-value:4.21E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.45|P-value:7.09E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.99|P-value:1.10E-4 ID:SGTC_2869|Compound:9037858|FD-Score:5.65|P-value:8.75E-8 ID:SGTC_2878|Compound:9043973|FD-Score:4.37|P-value:2.63E-5 ID:SGTC_2879|Compound:9041815|FD-Score:-4.55|P-value:1.26E-5 ID:SGTC_2895|Compound:9054447|FD-Score:3.57|P-value:4.75E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-5.33|P-value:3.99E-7 ID:SGTC_3220|Compound:9131269|FD-Score:3.49|P-value:6.29E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.01|P-value:1.04E-4

Top fitness defect scores for YNL143C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2869 9037858 5.65 32.5 µM 8.75E-8 3 8.24E-9
2 SGTC_52 0329-0193 5.37 875.0 nM 3.38E-7 TSC3-RPN4 12 3.97E-8
3 SGTC_47 0149-0135 4.89 24.2 µM 3.08E-6 TSC3-RPN4 8 5.17E-7
4 SGTC_2390 9097792 4.77 176.6 µM 5.10E-6 4 9.26E-7
5 SGTC_2019 4016004 4.51 108.0 µM 1.53E-5 13 3.31E-6
6 SGTC_2513 baicalein 4.47 25.6 µM 1.79E-5 calcium & mitochondrial duress 18 3.97E-6
7 SGTC_2878 9043973 4.37 26.0 µM 2.63E-5 9 6.22E-6
8 SGTC_2020 4017018 4.16 200.0 µM 6.01E-5 13 1.62E-5
9 SGTC_1696 st025591 4.10 34.8 µM 7.51E-5 SWF1 & branched chain AA biosynthesis 23 2.10E-5
10 SGTC_3304 9125678 4.01 46.1 µM 1.04E-4 44 3.07E-5
11 SGTC_2867 9039098 3.99 71.4 µM 1.10E-4 iron homeostasis 31 3.24E-5
12 SGTC_1180 1193-0155 3.68 285.0 µM 3.27E-4 19 1.15E-4
13 SGTC_2319 6033012 3.65 152.6 µM 3.66E-4 tubulin folding & SWR complex 37 1.31E-4
14 SGTC_2810 7959871 3.61 45.5 µM 4.21E-4 copper-dependent oxidative stress 50 1.54E-4
15 SGTC_2895 9054447 3.57 58.4 µM 4.75E-4 15 1.77E-4
16 SGTC_3220 9131269 3.49 49.5 µM 6.29E-4 20 2.45E-4
17 SGTC_2860 9025725 3.45 39.0 µM 7.09E-4 RPP1 & pyrimidine depletion 21 2.81E-4
18 SGTC_1842 st055362 3.41 61.2 µM 8.01E-4 26 3.24E-4
19 SGTC_402 epigallocatechin gallate 3.38 10.0 µM 8.70E-4 58 3.57E-4
20 SGTC_1715 st032160 3.35 10.2 µM 9.77E-4 65 4.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 5.51E-36 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.100 5.76E-9 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.096 2.43E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.094 5.01E-8 YBR278W DPB3 hom Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication
0.084 1.19E-6 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.081 2.93E-6 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.081 3.06E-6 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.079 4.38E-6 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.079 4.58E-6 YPL225W YPL225W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.074 1.64E-5 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.074 2.00E-5 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.069 6.78E-5 YMR197C VTI1 het Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
0.067 1.03E-4 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.065 1.64E-4 YLR314C CDC3 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.063 2.37E-4 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline