YNL144C_p

Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL144C / YNL144C

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.78|P-value:2.38E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.12|P-value:4.59E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.40|P-value:1.24E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.18|P-value:4.17E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:3.90|P-value:1.67E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:5.54|P-value:1.77E-9 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.07|P-value:4.63E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.10|P-value:4.93E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.67|P-value:4.63E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.25|P-value:2.78E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.23|P-value:2.47E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.53|P-value:5.68E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:3.12|P-value:4.58E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.46|P-value:1.14E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.16|P-value:3.93E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.08|P-value:4.51E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.29|P-value:1.93E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.65|P-value:3.65E-7 ID:SGTC_759|Compound:3486-0358|FD-Score:3.02|P-value:6.72E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.35|P-value:1.84E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:2.97|P-value:7.85E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.62|P-value:4.92E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.36|P-value:1.72E-6 ID:SGTC_918|Compound:glabranin|FD-Score:-2.89|P-value:9.33E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.41|P-value:3.92E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:3.66|P-value:4.94E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.99|P-value:1.10E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.00|P-value:7.17E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.15|P-value:4.04E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.60|P-value:5.32E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.13|P-value:4.38E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.11|P-value:4.09E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.94|P-value:1.34E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.17|P-value:3.19E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.86|P-value:2.02E-5 ID:SGTC_1794|Compound:st048918|FD-Score:3.08|P-value:5.35E-4 ID:SGTC_1932|Compound:st074806|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.53|P-value:7.29E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.90|P-value:1.62E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.13|P-value:3.65E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.38|P-value:1.51E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-3.00|P-value:6.21E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.96|P-value:7.04E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-2.98|P-value:6.50E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.57|P-value:7.33E-5 ID:SGTC_2276|Compound:7947513|FD-Score:3.16|P-value:3.84E-4 ID:SGTC_2279|Compound:7948423|FD-Score:2.93|P-value:9.07E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.27|P-value:2.14E-4 ID:SGTC_2469|Compound:5655019|FD-Score:2.92|P-value:9.48E-4 ID:SGTC_2474|Compound:5321570|FD-Score:2.99|P-value:7.41E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.14|P-value:3.54E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-2.96|P-value:7.19E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.35|P-value:1.80E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.27|P-value:2.15E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.42|P-value:1.13E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.22|P-value:2.64E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-2.99|P-value:6.23E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.34|P-value:1.61E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.90|P-value:1.65E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-3.31|P-value:1.80E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.11|P-value:4.63E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.24|P-value:2.40E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.73|P-value:3.53E-5 ID:SGTC_3011|Compound:9081274|FD-Score:3.27|P-value:2.48E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.51|P-value:7.99E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-3.00|P-value:6.11E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.78|P-value:2.38E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.12|P-value:4.59E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.40|P-value:1.24E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.18|P-value:4.17E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:3.90|P-value:1.67E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:5.54|P-value:1.77E-9 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.07|P-value:4.63E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.10|P-value:4.93E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.67|P-value:4.63E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.25|P-value:2.78E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.23|P-value:2.47E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.53|P-value:5.68E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:3.12|P-value:4.58E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.46|P-value:1.14E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.16|P-value:3.93E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.08|P-value:4.51E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.29|P-value:1.93E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.65|P-value:3.65E-7 ID:SGTC_759|Compound:3486-0358|FD-Score:3.02|P-value:6.72E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.35|P-value:1.84E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:2.97|P-value:7.85E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.62|P-value:4.92E-5 ID:SGTC_917|Compound:harmaline|FD-Score:4.36|P-value:1.72E-6 ID:SGTC_918|Compound:glabranin|FD-Score:-2.89|P-value:9.33E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.41|P-value:3.92E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:3.66|P-value:4.94E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.99|P-value:1.10E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.00|P-value:7.17E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.15|P-value:4.04E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.60|P-value:5.32E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.13|P-value:4.38E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.11|P-value:4.09E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.94|P-value:1.34E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.17|P-value:3.19E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.86|P-value:2.02E-5 ID:SGTC_1794|Compound:st048918|FD-Score:3.08|P-value:5.35E-4 ID:SGTC_1932|Compound:st074806|FD-Score:2.93|P-value:9.15E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.53|P-value:7.29E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.90|P-value:1.62E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-3.13|P-value:3.65E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.38|P-value:1.51E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-3.00|P-value:6.21E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.96|P-value:7.04E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-2.98|P-value:6.50E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.57|P-value:7.33E-5 ID:SGTC_2276|Compound:7947513|FD-Score:3.16|P-value:3.84E-4 ID:SGTC_2279|Compound:7948423|FD-Score:2.93|P-value:9.07E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.27|P-value:2.14E-4 ID:SGTC_2469|Compound:5655019|FD-Score:2.92|P-value:9.48E-4 ID:SGTC_2474|Compound:5321570|FD-Score:2.99|P-value:7.41E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.14|P-value:3.54E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-2.96|P-value:7.19E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.35|P-value:1.80E-6 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.27|P-value:2.15E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.42|P-value:1.13E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.22|P-value:2.64E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:-2.99|P-value:6.23E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.34|P-value:1.61E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.90|P-value:1.65E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-3.31|P-value:1.80E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.11|P-value:4.63E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.24|P-value:2.40E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.73|P-value:3.53E-5 ID:SGTC_3011|Compound:9081274|FD-Score:3.27|P-value:2.48E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.51|P-value:7.99E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-3.00|P-value:6.11E-4

Top fitness defect scores for YNL144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_88 0180-0332 5.54 8.7 µM 1.77E-9 1 1.55E-8
2 SGTC_922 1866-0035 5.41 480.0 µM 3.92E-9 excess fatty acid 26 3.12E-8
3 SGTC_702 1488-0190 4.65 94.0 µM 3.65E-7 amide catabolism 5 1.68E-6
4 SGTC_2094 5332512 4.38 191.7 µM 1.51E-6 15 5.87E-6
5 SGTC_917 harmaline 4.36 728.1 nM 1.72E-6 ergosterol biosynthesis 17 6.60E-6
6 SGTC_2549 cedrol 4.35 20.9 µM 1.80E-6 10 6.87E-6
7 SGTC_52 0329-0193 4.18 875.0 nM 4.17E-6 TSC3-RPN4 26 1.44E-5
8 SGTC_1029 k015-0030 3.99 64.7 µM 1.10E-5 27 3.37E-5
9 SGTC_1611 st001856 3.94 99.4 µM 1.34E-5 16 4.02E-5
10 SGTC_2007 4011539 3.90 71.8 µM 1.62E-5 cell wall signaling 63 4.75E-5
11 SGTC_2822 7994718 3.90 71.4 µM 1.65E-5 18 4.84E-5
12 SGTC_60 0986-0278 3.90 202.0 µM 1.67E-5 17 4.90E-5
13 SGTC_1792 st045773 3.86 43.6 µM 2.02E-5 28 5.79E-5
14 SGTC_2993 9054257 3.73 71.4 µM 3.53E-5 fatty acid desaturase (OLE1) 53 9.46E-5
15 SGTC_129 0088-0017 3.67 176.6 µM 4.63E-5 73 1.20E-4
16 SGTC_996 3970-0799 3.66 1.8 µM 4.94E-5 99 1.27E-4
17 SGTC_2273 7815444 3.57 169.1 µM 7.33E-5 34 1.80E-4
18 SGTC_3083 9117465 3.49 49.5 µM 1.03E-4 34 2.43E-4
19 SGTC_535 2293-4129 3.46 48.2 µM 1.14E-4 NEO1 86 2.66E-4
20 SGTC_769 0302-0231 3.35 76.0 µM 1.84E-4 80 4.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.93E-13 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.099 9.46E-9 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.095 3.43E-8 YPL212C PUS1 hom tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
0.094 5.11E-8 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.092 8.13E-8 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.091 1.44E-7 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.090 1.77E-7 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.088 3.14E-7 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.088 3.66E-7 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.081 2.28E-6 YPR118W MRI1 hom 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
0.081 2.40E-6 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.081 2.70E-6 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.080 3.12E-6 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.080 3.64E-6 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.076 1.08E-5 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors