YNL146C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL146C-A / YNL146C-A

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.31|P-value:3.25E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.12|P-value:7.80E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.12|P-value:6.43E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.39|P-value:1.50E-8 ID:SGTC_277|Compound:nystatin|FD-Score:3.30|P-value:3.37E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.19|P-value:5.04E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.51|P-value:1.48E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.91|P-value:2.78E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.68|P-value:9.24E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.75|P-value:5.63E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.62|P-value:1.02E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.68|P-value:7.50E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.68|P-value:7.52E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.11|P-value:6.72E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.85|P-value:3.60E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.91|P-value:2.84E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.63|P-value:9.22E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.83|P-value:4.96E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.21|P-value:7.29E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.34|P-value:2.03E-8 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.41|P-value:2.67E-4 ID:SGTC_1558|Compound:st069300|FD-Score:6.04|P-value:2.80E-10 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.08|P-value:7.31E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.22|P-value:4.50E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.17|P-value:6.50E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.65|P-value:8.47E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-5.57|P-value:7.17E-9 ID:SGTC_2282|Compound:7944268|FD-Score:7.00|P-value:3.17E-13 ID:SGTC_2310|Compound:7668677|FD-Score:3.02|P-value:9.28E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.80|P-value:5.70E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.39|P-value:2.37E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.36|P-value:3.16E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.39|P-value:2.39E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.10|P-value:6.94E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.14|P-value:7.07E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.04|P-value:8.63E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.14|P-value:6.00E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.82|P-value:5.22E-5 ID:SGTC_3040|Compound:9091894|FD-Score:3.42|P-value:2.09E-4 ID:SGTC_3069|Compound:9117009|FD-Score:6.32|P-value:4.17E-11 ID:SGTC_3070|Compound:9117005|FD-Score:-3.73|P-value:7.39E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.65|P-value:1.03E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.23|P-value:4.29E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.46|P-value:1.79E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.31|P-value:3.25E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.12|P-value:7.80E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.12|P-value:6.43E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.39|P-value:1.50E-8 ID:SGTC_277|Compound:nystatin|FD-Score:3.30|P-value:3.37E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.19|P-value:5.04E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.51|P-value:1.48E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.91|P-value:2.78E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.68|P-value:9.24E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.75|P-value:5.63E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.62|P-value:1.02E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.68|P-value:7.50E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:3.68|P-value:7.52E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.11|P-value:6.72E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.85|P-value:3.60E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.91|P-value:2.84E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.63|P-value:9.22E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.83|P-value:4.96E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.21|P-value:7.29E-6 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.34|P-value:2.03E-8 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.41|P-value:2.67E-4 ID:SGTC_1558|Compound:st069300|FD-Score:6.04|P-value:2.80E-10 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.08|P-value:7.31E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.37|P-value:2.54E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.22|P-value:4.50E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.17|P-value:6.50E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.65|P-value:8.47E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-5.57|P-value:7.17E-9 ID:SGTC_2282|Compound:7944268|FD-Score:7.00|P-value:3.17E-13 ID:SGTC_2310|Compound:7668677|FD-Score:3.02|P-value:9.28E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.80|P-value:5.70E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.39|P-value:2.37E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.36|P-value:3.16E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.39|P-value:2.39E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.10|P-value:6.94E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.14|P-value:7.07E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.04|P-value:8.63E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.14|P-value:6.00E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.82|P-value:5.22E-5 ID:SGTC_3040|Compound:9091894|FD-Score:3.42|P-value:2.09E-4 ID:SGTC_3069|Compound:9117009|FD-Score:6.32|P-value:4.17E-11 ID:SGTC_3070|Compound:9117005|FD-Score:-3.73|P-value:7.39E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.65|P-value:1.03E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.23|P-value:4.29E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.46|P-value:1.79E-4

Top fitness defect scores for YNL146C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2282 7944268 7.00 200.0 µM 3.17E-13 RPP1 & pyrimidine depletion 2 1.24E-12
2 SGTC_3069 9117009 6.32 49.5 µM 4.17E-11 60S ribosome export 1 1.29E-10
3 SGTC_1558 st069300 6.04 45.6 µM 2.80E-10 1 7.92E-10
4 SGTC_236 1509-0011 5.39 5.3 µM 1.50E-8 306 3.52E-8
5 SGTC_1388 3346-4487 5.34 254.0 µM 2.03E-8 5 4.68E-8
6 SGTC_743 1275-0778 4.62 158.0 µM 1.02E-6 excess fatty acid 24 1.96E-6
7 SGTC_1383 3049-0032 4.21 20.7 µM 7.29E-6 60S ribosome export 18 1.27E-5
8 SGTC_705 1124-0212 3.91 310.0 µM 2.78E-5 14 4.54E-5
9 SGTC_1216 1165-0504 3.91 9.7 µM 2.84E-5 13 4.63E-5
10 SGTC_1212 0520-0165 3.85 585.0 µM 3.60E-5 35 5.80E-5
11 SGTC_734 2023-0417 3.75 80.0 µM 5.63E-5 ergosterol biosynthesis 22 8.89E-5
12 SGTC_784 4579-0127 3.68 173.0 µM 7.50E-5 29 1.17E-4
13 SGTC_816 0325-0417 3.68 81.3 µM 7.52E-5 16 1.17E-4
14 SGTC_2278 7948257 3.65 134.3 µM 8.47E-5 33 1.31E-4
15 SGTC_1260 0700-1617 3.63 7.8 µM 9.22E-5 calcium & mitochondrial duress 39 1.42E-4
16 SGTC_650 1328-0195 3.51 38.0 µM 1.48E-4 31 2.22E-4
17 SGTC_3332 9141069 3.46 11.2 µM 1.79E-4 31 2.67E-4
18 SGTC_3040 9091894 3.42 49.5 µM 2.09E-4 DNA intercalators 31 3.10E-4
19 SGTC_2444 5485484 3.39 36.4 µM 2.37E-4 54 3.50E-4
20 SGTC_2610 ononetin 3.39 44.2 µM 2.39E-4 69 3.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 6.91E-36 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.202 2.38E-32 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.202 4.29E-32 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.198 7.31E-31 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.191 7.95E-29 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.188 3.88E-28 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.188 5.15E-28 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.183 1.14E-26 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.183 1.34E-26 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.182 2.37E-26 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.181 4.90E-26 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.179 1.63E-25 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.177 4.48E-25 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.176 9.14E-25 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.175 2.08E-24 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit