YNL148C / ALF1

Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL148C / ALF1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.92|P-value:7.93E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.22|P-value:3.45E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.00|P-value:6.49E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.29|P-value:2.79E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:6.68|P-value:3.80E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:3.50E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.72|P-value:2.03E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:17.90|P-value:1.57E-47 ID:SGTC_86|Compound:0417-1630|FD-Score:3.88|P-value:8.86E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.86|P-value:4.58E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.97|P-value:3.20E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:5.44|P-value:5.99E-6 ID:SGTC_229|Compound:benomyl|FD-Score:6.08|P-value:4.89E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:5.73|P-value:1.98E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.33|P-value:2.48E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.85|P-value:4.66E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:5.08|P-value:2.13E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:5.18|P-value:1.53E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.99|P-value:6.63E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.02|P-value:5.99E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.43|P-value:6.12E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.01|P-value:6.25E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.49|P-value:1.51E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.39|P-value:2.06E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.91|P-value:3.80E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.08|P-value:2.15E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:5.33|P-value:9.02E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.11|P-value:4.75E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.55|P-value:1.26E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.95|P-value:7.28E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.74|P-value:6.74E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.63|P-value:9.64E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:4.64|P-value:9.35E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.48|P-value:1.58E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.03|P-value:5.91E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:6.79|P-value:2.29E-8 ID:SGTC_897|Compound:1000-0139|FD-Score:8.30|P-value:1.17E-11 ID:SGTC_926|Compound:2268-1401|FD-Score:4.73|P-value:7.03E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.84|P-value:9.93E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.85|P-value:9.79E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:7.79|P-value:1.84E-10 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.99|P-value:7.00E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:6.86|P-value:1.63E-8 ID:SGTC_1066|Compound:ketoconazole|FD-Score:5.21|P-value:1.38E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-4.22|P-value:3.44E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:6.06|P-value:5.34E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.93|P-value:7.77E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:5.26|P-value:1.15E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.09|P-value:2.10E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.95|P-value:7.46E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.19|P-value:3.73E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.25|P-value:2.43E-7 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.63|P-value:9.68E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.27|P-value:2.92E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:5.43|P-value:6.26E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.91|P-value:8.25E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:7.18|P-value:3.67E-9 ID:SGTC_1608|Compound:st001473|FD-Score:3.88|P-value:9.02E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.30|P-value:2.70E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.59|P-value:1.11E-4 ID:SGTC_1831|Compound:st055328|FD-Score:6.06|P-value:5.27E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.05|P-value:5.65E-7 ID:SGTC_1921|Compound:5740136|FD-Score:7.75|P-value:2.21E-10 ID:SGTC_1933|Compound:st074711|FD-Score:4.69|P-value:8.03E-5 ID:SGTC_1952|Compound:st077036|FD-Score:4.40|P-value:1.99E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.29|P-value:2.77E-4 ID:SGTC_2018|Compound:5133068|FD-Score:8.19|P-value:2.11E-11 ID:SGTC_2067|Compound:5224629|FD-Score:4.03|P-value:5.93E-4 ID:SGTC_2090|Compound:5301565|FD-Score:7.00|P-value:8.67E-9 ID:SGTC_2151|Compound:5563267|FD-Score:3.89|P-value:8.77E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.82|P-value:1.42E-6 ID:SGTC_2225|Compound:6654152|FD-Score:5.76|P-value:1.78E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.80|P-value:1.50E-6 ID:SGTC_2246|Compound:7293507|FD-Score:18.60|P-value:3.51E-51 ID:SGTC_2323|Compound:6148992|FD-Score:4.75|P-value:6.61E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.32|P-value:2.51E-4 ID:SGTC_2401|Compound:5128683|FD-Score:6.69|P-value:3.57E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.79|P-value:2.32E-8 ID:SGTC_2426|Compound:5582046|FD-Score:4.58|P-value:1.14E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.43|P-value:1.15E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.97|P-value:6.91E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.80|P-value:1.49E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.86|P-value:4.52E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.96|P-value:3.24E-5 ID:SGTC_2681|Compound:menadione|FD-Score:5.40|P-value:6.96E-6 ID:SGTC_2701|Compound:st077767|FD-Score:6.69|P-value:3.60E-8 ID:SGTC_2739|Compound:tacrine|FD-Score:4.03|P-value:5.85E-4 ID:SGTC_2788|Compound:5282734|FD-Score:9.61|P-value:5.02E-15 ID:SGTC_2891|Compound:9063876|FD-Score:4.20|P-value:3.64E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.57|P-value:1.16E-4 ID:SGTC_2899|Compound:9053889|FD-Score:4.05|P-value:5.53E-4 ID:SGTC_2921|Compound:7974240|FD-Score:7.91|P-value:9.76E-11 ID:SGTC_2981|Compound:9013952|FD-Score:8.72|P-value:1.08E-12 ID:SGTC_3000|Compound:9075062|FD-Score:-4.00|P-value:6.47E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.94|P-value:7.47E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.72|P-value:7.28E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.76|P-value:6.27E-5 ID:SGTC_3282|Compound:9108498|FD-Score:5.83|P-value:1.33E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.42|P-value:1.87E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.14|P-value:1.74E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.92|P-value:7.93E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.22|P-value:3.45E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:4.00|P-value:6.49E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.29|P-value:2.79E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:6.68|P-value:3.80E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:4.21|P-value:3.50E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.72|P-value:2.03E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:17.90|P-value:1.57E-47 ID:SGTC_86|Compound:0417-1630|FD-Score:3.88|P-value:8.86E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.86|P-value:4.58E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.97|P-value:3.20E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:5.44|P-value:5.99E-6 ID:SGTC_229|Compound:benomyl|FD-Score:6.08|P-value:4.89E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:5.73|P-value:1.98E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:4.33|P-value:2.48E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.85|P-value:4.66E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:5.08|P-value:2.13E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:5.18|P-value:1.53E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.99|P-value:6.63E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.02|P-value:5.99E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.43|P-value:6.12E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:4.01|P-value:6.25E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.49|P-value:1.51E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.39|P-value:2.06E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.91|P-value:3.80E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:5.08|P-value:2.15E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:5.33|P-value:9.02E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.11|P-value:4.75E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.55|P-value:1.26E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.95|P-value:7.28E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.74|P-value:6.74E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.63|P-value:9.64E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:4.64|P-value:9.35E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.48|P-value:1.58E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.03|P-value:5.91E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:6.79|P-value:2.29E-8 ID:SGTC_897|Compound:1000-0139|FD-Score:8.30|P-value:1.17E-11 ID:SGTC_926|Compound:2268-1401|FD-Score:4.73|P-value:7.03E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.84|P-value:9.93E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.85|P-value:9.79E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:7.79|P-value:1.84E-10 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.99|P-value:7.00E-7 ID:SGTC_1064|Compound:honokiol|FD-Score:6.86|P-value:1.63E-8 ID:SGTC_1066|Compound:ketoconazole|FD-Score:5.21|P-value:1.38E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-4.22|P-value:3.44E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:6.06|P-value:5.34E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.93|P-value:7.77E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:5.26|P-value:1.15E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.09|P-value:2.10E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.95|P-value:7.46E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.19|P-value:3.73E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.25|P-value:2.43E-7 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.63|P-value:9.68E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.27|P-value:2.92E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:5.43|P-value:6.26E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.91|P-value:8.25E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:7.18|P-value:3.67E-9 ID:SGTC_1608|Compound:st001473|FD-Score:3.88|P-value:9.02E-4 ID:SGTC_1634|Compound:st006576|FD-Score:4.30|P-value:2.70E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.59|P-value:1.11E-4 ID:SGTC_1831|Compound:st055328|FD-Score:6.06|P-value:5.27E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.05|P-value:5.65E-7 ID:SGTC_1921|Compound:5740136|FD-Score:7.75|P-value:2.21E-10 ID:SGTC_1933|Compound:st074711|FD-Score:4.69|P-value:8.03E-5 ID:SGTC_1952|Compound:st077036|FD-Score:4.40|P-value:1.99E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.29|P-value:2.77E-4 ID:SGTC_2018|Compound:5133068|FD-Score:8.19|P-value:2.11E-11 ID:SGTC_2067|Compound:5224629|FD-Score:4.03|P-value:5.93E-4 ID:SGTC_2090|Compound:5301565|FD-Score:7.00|P-value:8.67E-9 ID:SGTC_2151|Compound:5563267|FD-Score:3.89|P-value:8.77E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.82|P-value:1.42E-6 ID:SGTC_2225|Compound:6654152|FD-Score:5.76|P-value:1.78E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.80|P-value:1.50E-6 ID:SGTC_2246|Compound:7293507|FD-Score:18.60|P-value:3.51E-51 ID:SGTC_2323|Compound:6148992|FD-Score:4.75|P-value:6.61E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.32|P-value:2.51E-4 ID:SGTC_2401|Compound:5128683|FD-Score:6.69|P-value:3.57E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.79|P-value:2.32E-8 ID:SGTC_2426|Compound:5582046|FD-Score:4.58|P-value:1.14E-4 ID:SGTC_2430|Compound:5571206|FD-Score:6.43|P-value:1.15E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.97|P-value:6.91E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.80|P-value:1.49E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.86|P-value:4.52E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.96|P-value:3.24E-5 ID:SGTC_2681|Compound:menadione|FD-Score:5.40|P-value:6.96E-6 ID:SGTC_2701|Compound:st077767|FD-Score:6.69|P-value:3.60E-8 ID:SGTC_2739|Compound:tacrine|FD-Score:4.03|P-value:5.85E-4 ID:SGTC_2788|Compound:5282734|FD-Score:9.61|P-value:5.02E-15 ID:SGTC_2891|Compound:9063876|FD-Score:4.20|P-value:3.64E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.57|P-value:1.16E-4 ID:SGTC_2899|Compound:9053889|FD-Score:4.05|P-value:5.53E-4 ID:SGTC_2921|Compound:7974240|FD-Score:7.91|P-value:9.76E-11 ID:SGTC_2981|Compound:9013952|FD-Score:8.72|P-value:1.08E-12 ID:SGTC_3000|Compound:9075062|FD-Score:-4.00|P-value:6.47E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.94|P-value:7.47E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.72|P-value:7.28E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.76|P-value:6.27E-5 ID:SGTC_3282|Compound:9108498|FD-Score:5.83|P-value:1.33E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.42|P-value:1.87E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.14|P-value:1.74E-5

Top fitness defect scores for YNL148C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2246 7293507 18.60 91.6 µM 3.51E-51 1 8.10E-78
2 SGTC_67 0335-0847 17.90 266.0 µM 1.57E-47 ubiquinone biosynthesis & proteasome 7 3.41E-72
3 SGTC_2788 5282734 9.61 71.4 µM 5.02E-15 2 3.53E-22
4 SGTC_2981 9013952 8.72 39.0 µM 1.08E-12 4 1.33E-18
5 SGTC_897 1000-0139 8.30 31.4 µM 1.17E-11 10 5.15E-17
6 SGTC_2018 5133068 8.19 143.0 µM 2.11E-11 1 1.27E-16
7 SGTC_2921 7974240 7.91 10.7 µM 9.76E-11 6 1.32E-15
8 SGTC_1023 4482-3888 7.79 16.0 µM 1.84E-10 TSC3-RPN4 3 3.48E-15
9 SGTC_1921 5740136 7.75 50.0 µM 2.21E-10 TRP & mitochondrial translation 4 4.63E-15
10 SGTC_1585 2',4'-dihydroxychalcone 7.18 10.4 µM 3.67E-9 6 3.40E-13
11 SGTC_2090 5301565 7.00 104.5 µM 8.67E-9 TSC3-RPN4 14 1.26E-12
12 SGTC_1064 honokiol 6.86 6.8 µM 1.63E-8 1 3.33E-12
13 SGTC_892 0929-0076 6.79 29.0 µM 2.29E-8 TRP & mitochondrial translation 4 5.56E-12
14 SGTC_2405 ticlatone 6.79 3.5 µM 2.32E-8 20 5.70E-12
15 SGTC_2401 5128683 6.69 200.0 µM 3.57E-8 5 1.10E-11
16 SGTC_2701 st077767 6.69 14.7 µM 3.60E-8 10 1.11E-11
17 SGTC_44 0929-0055 6.68 61.2 µM 3.80E-8 7 1.21E-11
18 SGTC_2430 5571206 6.43 200.0 µM 1.15E-7 19 6.53E-11
19 SGTC_1377 2944-0135 6.25 198.0 µM 2.43E-7 calcium & mitochondrial duress 10 2.05E-10
20 SGTC_229 benomyl 6.08 22.9 µM 4.89E-7 tubulin folding & SWR complex 17 5.95E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.319 8.89E-80 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.289 1.85E-65 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.273 4.29E-58 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.262 1.65E-53 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.244 1.07E-46 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.223 4.80E-39 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.222 1.38E-38 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.218 1.75E-37 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.218 1.92E-37 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.207 1.12E-33 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.203 1.60E-32 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.202 3.72E-32 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.193 1.59E-29 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.193 2.61E-29 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.192 3.54E-29 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting