YNL150W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL150W / YNL150W

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:3.67|P-value:4.72E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.62|P-value:5.48E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:13.70|P-value:7.40E-36 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.46|P-value:7.48E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.15|P-value:1.61E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:3.71|P-value:4.09E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.94|P-value:1.52E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.37|P-value:4.00E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:4.17|P-value:8.15E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.00|P-value:1.22E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-4.06|P-value:9.78E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.53|P-value:7.24E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:15.90|P-value:1.15E-47 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.50|P-value:2.43E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-3.42|P-value:8.37E-4 ID:SGTC_1865|Compound:st057639|FD-Score:5.00|P-value:3.04E-6 ID:SGTC_1925|Compound:st057770|FD-Score:3.50|P-value:7.87E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.49|P-value:8.30E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.60|P-value:5.78E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.95|P-value:1.46E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.37|P-value:9.80E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.56|P-value:6.60E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.46|P-value:9.13E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.70|P-value:3.49E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.77|P-value:2.74E-4 ID:SGTC_2463|Compound:5473429|FD-Score:4.13|P-value:9.57E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.93|P-value:1.93E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.24|P-value:1.09E-6 ID:SGTC_2511|Compound:berberine|FD-Score:4.06|P-value:1.23E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.67|P-value:4.61E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.20|P-value:7.39E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.76|P-value:3.44E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.51|P-value:7.64E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.36|P-value:6.12E-7 ID:SGTC_2835|Compound:9006588|FD-Score:4.71|P-value:1.05E-5 ID:SGTC_2923|Compound:7992654|FD-Score:5.10|P-value:2.00E-6 ID:SGTC_2931|Compound:9014674|FD-Score:5.18|P-value:1.39E-6 ID:SGTC_2939|Compound:9044578|FD-Score:4.02|P-value:1.42E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.91|P-value:1.68E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.67|P-value:4.72E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.62|P-value:5.48E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:13.70|P-value:7.40E-36 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.46|P-value:7.48E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.15|P-value:1.61E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:3.71|P-value:4.09E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.94|P-value:1.52E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.37|P-value:4.00E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:4.17|P-value:8.15E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.00|P-value:1.22E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-4.06|P-value:9.78E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.53|P-value:7.24E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:15.90|P-value:1.15E-47 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.50|P-value:2.43E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-3.42|P-value:8.37E-4 ID:SGTC_1865|Compound:st057639|FD-Score:5.00|P-value:3.04E-6 ID:SGTC_1925|Compound:st057770|FD-Score:3.50|P-value:7.87E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.49|P-value:8.30E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.60|P-value:5.78E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-3.95|P-value:1.46E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.37|P-value:9.80E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.56|P-value:6.60E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.46|P-value:9.13E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.70|P-value:3.49E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.77|P-value:2.74E-4 ID:SGTC_2463|Compound:5473429|FD-Score:4.13|P-value:9.57E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.93|P-value:1.93E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.24|P-value:1.09E-6 ID:SGTC_2511|Compound:berberine|FD-Score:4.06|P-value:1.23E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.67|P-value:4.61E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.20|P-value:7.39E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.76|P-value:3.44E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.51|P-value:7.64E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.36|P-value:6.12E-7 ID:SGTC_2835|Compound:9006588|FD-Score:4.71|P-value:1.05E-5 ID:SGTC_2923|Compound:7992654|FD-Score:5.10|P-value:2.00E-6 ID:SGTC_2931|Compound:9014674|FD-Score:5.18|P-value:1.39E-6 ID:SGTC_2939|Compound:9044578|FD-Score:4.02|P-value:1.42E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.91|P-value:1.68E-4

Top fitness defect scores for YNL150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1510 1123-0200 15.90 71.5 µM 1.15E-47 1 2.29E-57 6.49
2 SGTC_315 k915-0449 13.70 187.0 µM 7.40E-36 2 4.40E-43 4.99
3 SGTC_2817 7995342 5.36 71.4 µM 6.12E-7 1 4.08E-8 0.54
4 SGTC_2475 5812728 5.24 15.0 µM 1.09E-6 mitochondrial processes 10 8.21E-8 0.37
5 SGTC_2931 9014674 5.18 55.7 µM 1.39E-6 2 1.09E-7 0.56
6 SGTC_367 0335-0881 5.15 7.1 µM 1.61E-6 ubiquinone biosynthesis & proteasome 12 1.31E-7 0.32
7 SGTC_2923 7992654 5.10 58.1 µM 2.00E-6 Golgi 2 1.70E-7 0.09
8 SGTC_1865 st057639 5.00 52.2 µM 3.04E-6 1 2.83E-7 0.80
9 SGTC_2835 9006588 4.71 71.4 µM 1.05E-5 4 1.26E-6 0.03
10 SGTC_1585 2',4'-dihydroxychalcone 4.50 10.4 µM 2.43E-5 7 3.47E-6 0.28
11 SGTC_860 0443-0016 4.37 25.1 µM 4.00E-5 7 6.32E-6 0.06
12 SGTC_2649 anisomycin 4.20 9.6 µM 7.39E-5 3 1.33E-5 0.07
13 SGTC_922 1866-0035 4.17 480.0 µM 8.15E-5 excess fatty acid 10 1.49E-5 0.34
14 SGTC_2463 5473429 4.13 200.0 µM 9.57E-5 ERG2 3 1.81E-5 0.28
15 SGTC_2511 berberine 4.06 10.5 µM 1.23E-4 60S ribosome export 9 2.45E-5 0.14
16 SGTC_2939 9044578 4.02 71.4 µM 1.42E-4 5 2.91E-5 0.00
17 SGTC_2470 5664817 3.93 21.7 µM 1.93E-4 5 4.20E-5 0.35
18 SGTC_2682 pyrogallin 3.76 40.0 µM 3.44E-4 copper-dependent oxidative stress 4 8.46E-5 0.33
19 SGTC_594 1487-1584 3.71 10.8 µM 4.09E-4 11 1.04E-4 0.03
20 SGTC_2531 methyl deoxycholate 3.67 70.1 µM 4.61E-4 7 1.20E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.483 7.40E-196 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.184 6.72E-27 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.119 3.87E-12 YBR106W PHO88 hom Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
0.119 3.89E-12 YGR260W TNA1 hom High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
0.118 7.70E-12 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.116 1.50E-11 YGL159W_p YGL159W_p hom Putative protein of unknown function; deletion mutant has no detectable phenotype
0.110 1.82E-10 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.102 3.56E-9 YPR053C_d YPR053C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
0.102 3.60E-9 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.099 9.11E-9 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.098 1.21E-8 YBR171W SEC66 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.097 1.63E-8 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.097 2.12E-8 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.097 2.11E-8 YGR089W NNF2 hom Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
0.096 2.85E-8 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication