YNL151C / RPC31

RNA polymerase III subunit C31

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL151C / RPC31

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.66|P-value:7.45E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.65|P-value:7.57E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:3.13|P-value:5.74E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.03|P-value:8.37E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.89|P-value:2.77E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.15|P-value:8.50E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.63|P-value:2.58E-9 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.12|P-value:5.94E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.09|P-value:6.74E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.85|P-value:3.21E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:3.07|P-value:7.29E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.89|P-value:2.76E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.13|P-value:5.74E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.88|P-value:2.04E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.28|P-value:3.31E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.46|P-value:1.67E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.02|P-value:1.51E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.09|P-value:6.73E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.73|P-value:5.39E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.58|P-value:1.02E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.26|P-value:4.87E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:5.86|P-value:6.03E-10 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.45|P-value:1.76E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.08|P-value:6.98E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.20|P-value:4.55E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.04|P-value:8.20E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.11|P-value:6.34E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.06|P-value:7.54E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.32|P-value:2.87E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.92|P-value:2.41E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.18|P-value:4.94E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.61|P-value:2.98E-9 ID:SGTC_2128|Compound:5255449|FD-Score:4.16|P-value:8.06E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.00|P-value:9.27E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.64|P-value:7.78E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.46|P-value:1.90E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.95|P-value:2.03E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.01|P-value:8.93E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.73|P-value:4.68E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.83|P-value:3.61E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.73|P-value:5.47E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.70|P-value:6.15E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.34|P-value:2.68E-4 ID:SGTC_2804|Compound:7954240|FD-Score:6.28|P-value:3.63E-11 ID:SGTC_2851|Compound:9015922|FD-Score:-3.55|P-value:1.13E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-5.53|P-value:4.81E-9 ID:SGTC_2862|Compound:9027634|FD-Score:-4.04|P-value:1.38E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.70|P-value:6.31E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.88|P-value:2.86E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.95|P-value:3.24E-10 ID:SGTC_2988|Compound:9073640|FD-Score:3.20|P-value:4.45E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.75|P-value:4.17E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-6.52|P-value:6.77E-12 ID:SGTC_3080|Compound:9117754|FD-Score:-3.22|P-value:4.13E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.48|P-value:1.54E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.07|P-value:7.28E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.61|P-value:2.87E-9 ID:SGTC_3225|Compound:9130819|FD-Score:3.44|P-value:1.76E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.84|P-value:3.37E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.13|P-value:5.86E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.16|P-value:5.15E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.66|P-value:7.45E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.65|P-value:7.57E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:3.13|P-value:5.74E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.03|P-value:8.37E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.89|P-value:2.77E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.15|P-value:8.50E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.63|P-value:2.58E-9 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.12|P-value:5.94E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.09|P-value:6.74E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.85|P-value:3.21E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:3.07|P-value:7.29E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.89|P-value:2.76E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.13|P-value:5.74E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.88|P-value:2.04E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.28|P-value:3.31E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.46|P-value:1.67E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.02|P-value:1.51E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.09|P-value:6.73E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.73|P-value:5.39E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.58|P-value:1.02E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.26|P-value:4.87E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:5.86|P-value:6.03E-10 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.45|P-value:1.76E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.08|P-value:6.98E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.20|P-value:4.55E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.04|P-value:8.20E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.11|P-value:6.34E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.06|P-value:7.54E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.32|P-value:2.87E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.92|P-value:2.41E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.18|P-value:4.94E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.61|P-value:2.98E-9 ID:SGTC_2128|Compound:5255449|FD-Score:4.16|P-value:8.06E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.00|P-value:9.27E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.64|P-value:7.78E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.46|P-value:1.90E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.95|P-value:2.03E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.01|P-value:8.93E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-4.73|P-value:4.68E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.83|P-value:3.61E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.73|P-value:5.47E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.70|P-value:6.15E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.34|P-value:2.68E-4 ID:SGTC_2804|Compound:7954240|FD-Score:6.28|P-value:3.63E-11 ID:SGTC_2851|Compound:9015922|FD-Score:-3.55|P-value:1.13E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-5.53|P-value:4.81E-9 ID:SGTC_2862|Compound:9027634|FD-Score:-4.04|P-value:1.38E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.70|P-value:6.31E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.88|P-value:2.86E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.55|P-value:1.14E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.95|P-value:3.24E-10 ID:SGTC_2988|Compound:9073640|FD-Score:3.20|P-value:4.45E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.75|P-value:4.17E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-6.52|P-value:6.77E-12 ID:SGTC_3080|Compound:9117754|FD-Score:-3.22|P-value:4.13E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.48|P-value:1.54E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.07|P-value:7.28E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.61|P-value:2.87E-9 ID:SGTC_3225|Compound:9130819|FD-Score:3.44|P-value:1.76E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.84|P-value:3.37E-5 ID:SGTC_3248|Compound:9135562|FD-Score:-3.13|P-value:5.86E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.16|P-value:5.15E-4

Top fitness defect scores for YNL151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2804 7954240 6.28 19.5 µM 3.63E-11 4 1.69E-10 0.58
2 SGTC_2959 9079155 5.95 11.0 µM 3.24E-10 3 1.30E-9 0.87
3 SGTC_1180 1193-0155 5.86 285.0 µM 6.03E-10 1 2.32E-9 1.48
4 SGTC_145 3737-0113 5.63 38.4 µM 2.58E-9 DNA intercalators 20 8.97E-9 0.01
5 SGTC_3210 9128157 5.61 49.5 µM 2.87E-9 1 9.91E-9 0.50
6 SGTC_1926 methyl fluorone black 5.61 53.6 µM 2.98E-9 DNA intercalators 12 1.03E-8 0.25
7 SGTC_651 3253-0966 4.88 34.4 µM 2.04E-7 calcium & mitochondrial duress 1 5.25E-7 0.46
8 SGTC_3027 9089541 4.75 49.5 µM 4.17E-7 fatty acid desaturase (OLE1) 12 1.02E-6 0.49
9 SGTC_2604 4'-hydroxychalcone 4.46 11.3 µM 1.90E-6 9 4.18E-6 0.17
10 SGTC_2128 5255449 4.16 168.5 µM 8.06E-6 8 1.61E-5 0.38
11 SGTC_144 4161-2749 4.15 112.4 µM 8.50E-6 DNA intercalators 12 1.69E-5 0.01
12 SGTC_896 0964-0007 4.02 44.5 µM 1.51E-5 8 2.89E-5 0.02
13 SGTC_1568 digitonin 3.92 820.0 nM 2.41E-5 sphingolipid biosynthesis & PDR1 16 4.48E-5 0.12
14 SGTC_392 N-ethylmaleimide 3.89 8.3 µM 2.76E-5 RNA pol III & RNase P/MRP 14 5.08E-5 0.17
15 SGTC_143 4032-1194 3.89 15.7 µM 2.77E-5 16 5.09E-5 0.01
16 SGTC_2871 9038510 3.88 13.0 µM 2.86E-5 4 5.25E-5 0.11
17 SGTC_264 promethazine 3.85 12.5 mM 3.21E-5 DNA intercalators 23 5.84E-5 0.00
18 SGTC_3236 9132701 3.84 49.5 µM 3.37E-5 TSC3-RPN4 4 6.11E-5 0.22
19 SGTC_2666 tannic acid 3.83 100.0 µM 3.61E-5 iron homeostasis 11 6.52E-5 0.10
20 SGTC_1043 0916-0009 3.73 19.3 µM 5.39E-5 7 9.47E-5 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 4.29E-36 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.213 1.04E-35 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.194 9.68E-30 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.194 1.10E-29 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.186 2.38E-27 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.184 7.91E-27 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.182 1.91E-26 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.182 2.41E-26 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.162 4.35E-21 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.155 1.73E-19 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.155 1.74E-19 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.155 2.51E-19 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.151 1.25E-18 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.149 4.89E-18 YDL102W POL3 het Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.144 5.69E-17 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar