YNL152W / INN1

Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL152W / INN1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.50|P-value:3.89E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.99|P-value:4.24E-18 ID:SGTC_159|Compound:3970-0959|FD-Score:3.50|P-value:3.85E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.22|P-value:9.87E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.52|P-value:3.65E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.35|P-value:6.51E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.25|P-value:9.02E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.59|P-value:2.85E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.70|P-value:3.29E-6 ID:SGTC_1516|Compound:st013856|FD-Score:3.25|P-value:9.06E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.96|P-value:1.01E-6 ID:SGTC_1634|Compound:st006576|FD-Score:-3.66|P-value:2.56E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.30|P-value:1.89E-5 ID:SGTC_1794|Compound:st048918|FD-Score:-4.18|P-value:3.66E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.59|P-value:2.87E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.97|P-value:7.08E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.81|P-value:2.02E-6 ID:SGTC_2043|Compound:5101342|FD-Score:4.91|P-value:1.25E-6 ID:SGTC_2135|Compound:5326629|FD-Score:3.40|P-value:5.56E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.34|P-value:1.61E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.92|P-value:1.01E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.79|P-value:1.37E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.31|P-value:8.69E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.24|P-value:9.34E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.28|P-value:8.24E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.32|P-value:7.10E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.71|P-value:3.93E-6 ID:SGTC_2950|Compound:9072895|FD-Score:-3.51|P-value:4.40E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.35|P-value:6.42E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.50|P-value:4.58E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.50|P-value:3.89E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.99|P-value:4.24E-18 ID:SGTC_159|Compound:3970-0959|FD-Score:3.50|P-value:3.85E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.22|P-value:9.87E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.52|P-value:3.65E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.35|P-value:6.51E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.25|P-value:9.02E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.59|P-value:2.85E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.70|P-value:3.29E-6 ID:SGTC_1516|Compound:st013856|FD-Score:3.25|P-value:9.06E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.96|P-value:1.01E-6 ID:SGTC_1634|Compound:st006576|FD-Score:-3.66|P-value:2.56E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.30|P-value:1.89E-5 ID:SGTC_1794|Compound:st048918|FD-Score:-4.18|P-value:3.66E-5 ID:SGTC_1949|Compound:st076024|FD-Score:3.59|P-value:2.87E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.97|P-value:7.08E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.81|P-value:2.02E-6 ID:SGTC_2043|Compound:5101342|FD-Score:4.91|P-value:1.25E-6 ID:SGTC_2135|Compound:5326629|FD-Score:3.40|P-value:5.56E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.34|P-value:1.61E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.92|P-value:1.01E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.79|P-value:1.37E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.31|P-value:8.69E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.24|P-value:9.34E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.28|P-value:8.24E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.32|P-value:7.10E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.71|P-value:3.93E-6 ID:SGTC_2950|Compound:9072895|FD-Score:-3.51|P-value:4.40E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.35|P-value:6.42E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.50|P-value:4.58E-4

Top fitness defect scores for YNL152W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_69 0096-0274 8.99 206.7 µM 4.24E-18 mitochondrial processes 7 1.27E-19 0.08
2 SGTC_1632 st005650 4.96 90.0 µM 1.01E-6 2 3.55E-7 0.65
3 SGTC_2043 5101342 4.91 149.0 µM 1.25E-6 SWF1 & branched chain AA biosynthesis 3 4.47E-7 0.71
4 SGTC_2039 Aminomethylbenzodioxan 4.81 200.0 µM 2.02E-6 1 7.51E-7 1.10
5 SGTC_1502 4534-4282 4.70 27.7 µM 3.29E-6 1 1.28E-6 0.89
6 SGTC_2396 5342950 4.34 42.8 µM 1.61E-5 RSC complex & mRNA processing 29 7.25E-6 0.09
7 SGTC_1771 st048882 4.30 4.2 µM 1.89E-5 RPP1 & pyrimidine depletion 6 8.60E-6 0.01
8 SGTC_2029 5175081 3.97 200.0 µM 7.08E-5 4 3.63E-5 0.02
9 SGTC_2783 7738165 3.79 71.4 µM 1.37E-4 6 7.43E-5 0.03
10 SGTC_1365 1672-3266 3.59 55.4 µM 2.85E-4 10 1.65E-4 0.04
11 SGTC_1949 st076024 3.59 69.1 µM 2.87E-4 9 1.67E-4 0.06
12 SGTC_709 3807-1509 3.52 243.0 µM 3.65E-4 RSC complex & mRNA processing 18 2.16E-4 0.08
13 SGTC_159 3970-0959 3.50 50.0 µM 3.85E-4 25 2.29E-4 0.03
14 SGTC_6 0844-0013 3.50 19.8 µM 3.89E-4 14 2.32E-4 0.03
15 SGTC_2135 5326629 3.40 150.4 µM 5.56E-4 RPP1 & pyrimidine depletion 9 3.42E-4 0.14
16 SGTC_2979 9012552 3.35 45.5 µM 6.42E-4 2 4.00E-4 0.03
17 SGTC_1003 4049-0218 3.35 100.0 µM 6.51E-4 17 4.06E-4 0.02
18 SGTC_2945 9067681 3.32 61.8 µM 7.10E-4 7 4.45E-4 0.10
19 SGTC_2942 9052777 3.28 62.2 µM 8.24E-4 15 5.24E-4 0.00
20 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 3.26 13.2 µM 8.72E-4 15 5.57E-4 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 7.28E-19 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.135 3.74E-15 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.134 5.98E-15 YNL334C SNO2 hom Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
0.130 4.00E-14 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.123 7.19E-13 YOL090W MSH2 hom Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
0.112 8.33E-11 YOL007C CSI2 hom Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
0.110 1.69E-10 YIL009C-A EST3 hom Component of the telomerase holoenzyme, involved in telomere replication
0.109 2.44E-10 YNL333W SNZ2 hom Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
0.109 2.49E-10 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.105 9.90E-10 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.105 1.18E-9 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.104 1.29E-9 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.104 1.53E-9 YNR065C_p YNR065C_p hom Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene
0.102 3.56E-9 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.101 4.05E-9 YML063W RPS1B hom Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication