YNL154C / YCK2

Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL154C / YCK2

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.35|P-value:5.37E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.05|P-value:3.47E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.95|P-value:5.24E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.28|P-value:6.33E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.17|P-value:2.34E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.72|P-value:1.42E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.70|P-value:1.38E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.74|P-value:1.30E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.31|P-value:1.05E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.92|P-value:7.48E-7 ID:SGTC_724|Compound:3910-0327|FD-Score:3.96|P-value:5.41E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:4.26|P-value:1.57E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.44|P-value:3.87E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.09|P-value:3.25E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.30|P-value:6.35E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.22|P-value:1.86E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.27|P-value:7.00E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:5.01|P-value:4.93E-7 ID:SGTC_1741|Compound:st038134|FD-Score:-4.20|P-value:1.89E-5 ID:SGTC_1747|Compound:st037496|FD-Score:4.11|P-value:2.97E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.42|P-value:4.26E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.23|P-value:7.45E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.32|P-value:5.94E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.22|P-value:8.32E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.88|P-value:7.08E-5 ID:SGTC_2124|Compound:5246320|FD-Score:3.70|P-value:1.50E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.75|P-value:1.25E-4 ID:SGTC_2345|Compound:9052315|FD-Score:5.45|P-value:5.10E-8 ID:SGTC_2350|Compound:9023895|FD-Score:3.18|P-value:9.44E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.10|P-value:3.09E-7 ID:SGTC_2456|Compound:5770359|FD-Score:3.90|P-value:6.92E-5 ID:SGTC_2466|Compound:5983409|FD-Score:-3.28|P-value:6.29E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.25|P-value:7.63E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.28|P-value:6.87E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.85|P-value:7.72E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.47|P-value:3.51E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.17|P-value:9.27E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.90|P-value:7.10E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.92|P-value:6.45E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.35|P-value:5.37E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.05|P-value:3.47E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.95|P-value:5.24E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.28|P-value:6.33E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.17|P-value:2.34E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.72|P-value:1.42E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.70|P-value:1.38E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.74|P-value:1.30E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.31|P-value:1.05E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.92|P-value:7.48E-7 ID:SGTC_724|Compound:3910-0327|FD-Score:3.96|P-value:5.41E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:4.01|P-value:4.49E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:4.26|P-value:1.57E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.44|P-value:3.87E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.09|P-value:3.25E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.30|P-value:6.35E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.22|P-value:1.86E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.27|P-value:7.00E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:5.01|P-value:4.93E-7 ID:SGTC_1741|Compound:st038134|FD-Score:-4.20|P-value:1.89E-5 ID:SGTC_1747|Compound:st037496|FD-Score:4.11|P-value:2.97E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.42|P-value:4.26E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.23|P-value:7.45E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.32|P-value:5.94E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.22|P-value:8.32E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.88|P-value:7.08E-5 ID:SGTC_2124|Compound:5246320|FD-Score:3.70|P-value:1.50E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.75|P-value:1.25E-4 ID:SGTC_2345|Compound:9052315|FD-Score:5.45|P-value:5.10E-8 ID:SGTC_2350|Compound:9023895|FD-Score:3.18|P-value:9.44E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.10|P-value:3.09E-7 ID:SGTC_2456|Compound:5770359|FD-Score:3.90|P-value:6.92E-5 ID:SGTC_2466|Compound:5983409|FD-Score:-3.28|P-value:6.29E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.25|P-value:7.63E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.28|P-value:6.87E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.85|P-value:7.72E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.47|P-value:3.51E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.17|P-value:9.27E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.90|P-value:7.10E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.92|P-value:6.45E-5

Top fitness defect scores for YNL154C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2345 9052315 5.45 157.4 µM 5.10E-8 6 2.57E-8
2 SGTC_514 4466-0038 5.31 2.6 nM 1.05E-7 cell wall 98 5.45E-8
3 SGTC_2409 alverine citrate 5.10 64.0 µM 3.09E-7 32 1.69E-7
4 SGTC_1430 4049-0248 5.01 69.1 µM 4.93E-7 6 2.75E-7
5 SGTC_652 0437-0092 4.92 114.0 µM 7.48E-7 3 4.24E-7
6 SGTC_757 1066-0008 4.26 322.0 µM 1.57E-5 Golgi 15 1.01E-5
7 SGTC_1307 1187-1599 4.22 12.2 µM 1.86E-5 PDR1 10 1.21E-5
8 SGTC_385 1494-0393 4.17 12.4 µM 2.34E-5 16 1.54E-5
9 SGTC_1747 st037496 4.11 66.6 µM 2.97E-5 15 1.98E-5
10 SGTC_1213 1315-0166 4.09 115.0 µM 3.25E-5 25 2.17E-5
11 SGTC_726 3448-4391 4.01 34.2 µM 4.49E-5 11 3.04E-5
12 SGTC_724 3910-0327 3.96 137.0 µM 5.41E-5 ERG2 17 3.69E-5
13 SGTC_3280 9140961 3.92 49.5 µM 6.45E-5 60S ribosome export 15 4.44E-5
14 SGTC_2456 5770359 3.90 74.5 µM 6.92E-5 18 4.78E-5
15 SGTC_3276 9139060 3.90 49.5 µM 7.10E-5 60S ribosome export 1 4.90E-5
16 SGTC_2275 7947463 3.75 200.0 µM 1.25E-4 iron homeostasis 40 8.88E-5
17 SGTC_504 lovastatin 3.74 124.0 µM 1.30E-4 16 9.23E-5
18 SGTC_386 1509-0011 3.72 3.1 µM 1.42E-4 154 1.01E-4
19 SGTC_2124 5246320 3.70 200.0 µM 1.50E-4 heme biosynthesis & mitochondrial translocase 24 1.07E-4
20 SGTC_2916 7875993 3.47 68.8 µM 3.51E-4 44 2.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.35E-11 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.112 7.81E-11 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.108 3.06E-10 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.106 6.96E-10 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.105 1.03E-9 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.105 1.11E-9 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.104 1.76E-9 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.099 1.03E-8 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.098 1.51E-8 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.092 8.26E-8 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.087 5.14E-7 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.085 8.37E-7 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.084 1.11E-6 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.084 1.23E-6 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.03E-6 YGR211W ZPR1 het Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress