YNL159C / ASI2

Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL159C / ASI2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.14|P-value:2.65E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.44|P-value:7.54E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.10|P-value:3.20E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:4.11E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.98|P-value:6.10E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:2.85|P-value:8.36E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:2.94|P-value:5.78E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.25|P-value:1.53E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:3.78|P-value:1.64E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:6.07|P-value:1.65E-11 ID:SGTC_955|Compound:1216-0110|FD-Score:3.04|P-value:4.03E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.95|P-value:2.98E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.74|P-value:3.17E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.94|P-value:7.47E-6 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.16|P-value:2.47E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.91|P-value:6.58E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.95|P-value:5.70E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.97|P-value:5.31E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.93|P-value:7.78E-6 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.06|P-value:3.66E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.52|P-value:5.41E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.65|P-value:2.92E-5 ID:SGTC_1613|Compound:st002381|FD-Score:-2.91|P-value:9.72E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.90|P-value:6.76E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.43|P-value:1.27E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-2.91|P-value:9.69E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.41|P-value:8.56E-5 ID:SGTC_2067|Compound:5224629|FD-Score:2.83|P-value:8.80E-4 ID:SGTC_2084|Compound:5306078|FD-Score:2.96|P-value:5.46E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.02|P-value:4.32E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.06|P-value:3.64E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.90|P-value:6.87E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.18|P-value:3.52E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-2.91|P-value:9.70E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.92|P-value:8.20E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-2.96|P-value:8.24E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.75|P-value:3.09E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.59|P-value:3.84E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.63|P-value:1.96E-7 ID:SGTC_2710|Compound:st078562|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.44|P-value:1.19E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.87|P-value:7.61E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.29|P-value:1.48E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.64|P-value:3.10E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.02|P-value:4.99E-6 ID:SGTC_3346|Compound:9158254|FD-Score:4.60|P-value:2.23E-7 ID:SGTC_3353|Compound:9151644|FD-Score:-3.35|P-value:1.78E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.14|P-value:2.65E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.44|P-value:7.54E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.10|P-value:3.20E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:4.11E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.98|P-value:6.10E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:2.85|P-value:8.36E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:2.94|P-value:5.78E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.25|P-value:1.53E-6 ID:SGTC_772|Compound:k072-0172|FD-Score:3.78|P-value:1.64E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:6.07|P-value:1.65E-11 ID:SGTC_955|Compound:1216-0110|FD-Score:3.04|P-value:4.03E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.95|P-value:2.98E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.74|P-value:3.17E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.94|P-value:7.47E-6 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.16|P-value:2.47E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.91|P-value:6.58E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.95|P-value:5.70E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.97|P-value:5.31E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.93|P-value:7.78E-6 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.06|P-value:3.66E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.52|P-value:5.41E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.65|P-value:2.92E-5 ID:SGTC_1613|Compound:st002381|FD-Score:-2.91|P-value:9.72E-4 ID:SGTC_1647|Compound:st011722|FD-Score:2.90|P-value:6.76E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.43|P-value:1.27E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-2.91|P-value:9.69E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.41|P-value:8.56E-5 ID:SGTC_2067|Compound:5224629|FD-Score:2.83|P-value:8.80E-4 ID:SGTC_2084|Compound:5306078|FD-Score:2.96|P-value:5.46E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.02|P-value:4.32E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.06|P-value:3.64E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.90|P-value:6.87E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.18|P-value:3.52E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-2.91|P-value:9.70E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.92|P-value:8.20E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-2.96|P-value:8.24E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.75|P-value:3.09E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.59|P-value:3.84E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.63|P-value:1.96E-7 ID:SGTC_2710|Compound:st078562|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.44|P-value:1.19E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.87|P-value:7.61E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.29|P-value:1.48E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.64|P-value:3.10E-5 ID:SGTC_3210|Compound:9128157|FD-Score:4.02|P-value:4.99E-6 ID:SGTC_3346|Compound:9158254|FD-Score:4.60|P-value:2.23E-7 ID:SGTC_3353|Compound:9151644|FD-Score:-3.35|P-value:1.78E-4

Top fitness defect scores for YNL159C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_954 1189-0853 6.07 2.9 µM 1.65E-11 endomembrane recycling 11 6.59E-10
2 SGTC_959 1222-0044 4.95 107.0 µM 2.98E-8 8 3.77E-7
3 SGTC_2692 st077426 4.63 47.7 µM 1.96E-7 12 1.86E-6
4 SGTC_3346 9158254 4.60 43.6 µM 2.23E-7 5 2.07E-6
5 SGTC_751 0833-0568 4.25 350.0 µM 1.53E-6 12 1.06E-5
6 SGTC_3210 9128157 4.02 49.5 µM 4.99E-6 45 2.89E-5
7 SGTC_288 1315-0019 3.98 35.1 µM 6.10E-6 RSC & ERG11 23 3.42E-5
8 SGTC_1047 2043-3044 3.94 82.0 µM 7.47E-6 34 4.06E-5
9 SGTC_1382 3002-2117 3.93 298.0 µM 7.78E-6 11 4.20E-5
10 SGTC_2518 prenyletin 3.92 46.3 µM 8.20E-6 12 4.40E-5
11 SGTC_772 k072-0172 3.78 35.3 µM 1.64E-5 21 7.93E-5
12 SGTC_1512 0259-0544 3.65 12.2 µM 2.92E-5 22 1.29E-4
13 SGTC_3207 9114163 3.64 49.5 µM 3.10E-5 41 1.36E-4
14 SGTC_2597 laccaic acid a 3.59 100.0 µM 3.84E-5 42 1.62E-4
15 SGTC_1460 k062-0059 3.52 9.2 µM 5.41E-5 Golgi 25 2.17E-4
16 SGTC_164 4100-3994 3.44 89.6 µM 7.54E-5 52 2.88E-4
17 SGTC_1942 st076330 3.41 65.2 µM 8.56E-5 43 3.21E-4
18 SGTC_530 4358-1714 3.30 28.0 µM 1.37E-4 69 4.77E-4
19 SGTC_3098 9119039 3.29 49.5 µM 1.48E-4 Golgi 61 5.09E-4
20 SGTC_2710 st078562 3.20 53.7 µM 2.06E-4 35 6.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.06E-15 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.111 1.34E-10 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.107 4.29E-10 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.103 1.96E-9 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.097 1.64E-8 YNL122C_p YNL122C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
0.097 1.68E-8 YBL096C_d YBL096C_d hom Non-essential protein of unknown function
0.097 2.12E-8 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.096 2.58E-8 YBR162W-A YSY6 hom Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.089 2.22E-7 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.59E-7 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.087 3.94E-7 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.083 1.69E-6 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.080 3.62E-6 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.079 4.07E-6 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.077 7.59E-6 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport