YNL160W / YGP1

Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL160W / YGP1

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:-3.49|P-value:1.51E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.86|P-value:3.77E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.38|P-value:2.36E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.57|P-value:1.10E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.02|P-value:8.76E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:6.01|P-value:3.34E-10 ID:SGTC_348|Compound:k064-0012|FD-Score:5.33|P-value:2.25E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.94|P-value:1.64E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.00|P-value:9.39E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.61|P-value:1.11E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:-4.01|P-value:1.71E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.69|P-value:7.80E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.31|P-value:3.05E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.41|P-value:2.41E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.26|P-value:4.16E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.16|P-value:5.95E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.63|P-value:9.86E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:6.25|P-value:6.87E-11 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.17|P-value:5.21E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.57|P-value:1.10E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.82|P-value:4.55E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.64|P-value:9.48E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.29|P-value:3.71E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.88|P-value:3.55E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.57|P-value:1.29E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.25|P-value:4.35E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.05|P-value:9.02E-4 ID:SGTC_1782|Compound:st039423|FD-Score:6.18|P-value:1.09E-10 ID:SGTC_1784|Compound:st039334|FD-Score:4.40|P-value:3.21E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_1857|Compound:st056007|FD-Score:4.62|P-value:1.08E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-6.22|P-value:6.51E-11 ID:SGTC_1915|Compound:st067105|FD-Score:-3.77|P-value:4.78E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.73|P-value:6.47E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.01|P-value:9.18E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.27|P-value:4.03E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.07|P-value:8.29E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.11|P-value:7.22E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.18|P-value:5.65E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:5.18|P-value:5.44E-8 ID:SGTC_2681|Compound:menadione|FD-Score:4.54|P-value:1.62E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.26|P-value:3.70E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.07|P-value:9.62E-8 ID:SGTC_2804|Compound:7954240|FD-Score:5.84|P-value:1.03E-9 ID:SGTC_2950|Compound:9072895|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.43|P-value:2.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.06|P-value:8.76E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.49|P-value:1.51E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.86|P-value:3.77E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.38|P-value:2.36E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.57|P-value:1.10E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.02|P-value:8.76E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:6.01|P-value:3.34E-10 ID:SGTC_348|Compound:k064-0012|FD-Score:5.33|P-value:2.25E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.94|P-value:1.64E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.00|P-value:9.39E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.61|P-value:1.11E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:-4.01|P-value:1.71E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.69|P-value:7.80E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.31|P-value:3.05E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.41|P-value:2.41E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.26|P-value:4.16E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.16|P-value:5.95E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.63|P-value:9.86E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:6.25|P-value:6.87E-11 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.17|P-value:5.21E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.57|P-value:1.10E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.82|P-value:4.55E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.64|P-value:9.48E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.29|P-value:3.71E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.88|P-value:3.55E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.57|P-value:1.29E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.25|P-value:4.35E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.05|P-value:9.02E-4 ID:SGTC_1782|Compound:st039423|FD-Score:6.18|P-value:1.09E-10 ID:SGTC_1784|Compound:st039334|FD-Score:4.40|P-value:3.21E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_1857|Compound:st056007|FD-Score:4.62|P-value:1.08E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-6.22|P-value:6.51E-11 ID:SGTC_1915|Compound:st067105|FD-Score:-3.77|P-value:4.78E-5 ID:SGTC_1958|Compound:st076513|FD-Score:3.73|P-value:6.47E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.11|P-value:7.30E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.01|P-value:9.18E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.27|P-value:4.03E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.07|P-value:8.29E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.11|P-value:7.22E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.18|P-value:5.65E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:5.18|P-value:5.44E-8 ID:SGTC_2681|Compound:menadione|FD-Score:4.54|P-value:1.62E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.26|P-value:3.70E-4 ID:SGTC_2694|Compound:st077685|FD-Score:5.07|P-value:9.62E-8 ID:SGTC_2804|Compound:7954240|FD-Score:5.84|P-value:1.03E-9 ID:SGTC_2950|Compound:9072895|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.43|P-value:2.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.06|P-value:8.76E-4

Top fitness defect scores for YNL160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_952 1185-0122 6.25 232.0 µM 6.87E-11 6 2.05E-10
2 SGTC_1782 st039423 6.18 80.6 µM 1.09E-10 1 3.16E-10
3 SGTC_341 1486-1430 6.01 230.0 µM 3.34E-10 4 9.15E-10
4 SGTC_2804 7954240 5.84 19.5 µM 1.03E-9 4 2.65E-9
5 SGTC_348 k064-0012 5.33 10.7 µM 2.25E-8 60S ribosome export 6 4.94E-8
6 SGTC_2673 kobusone 5.18 100.0 µM 5.44E-8 1 1.14E-7
7 SGTC_2694 st077685 5.07 81.9 µM 9.62E-8 endomembrane recycling 13 1.95E-7
8 SGTC_1857 st056007 4.62 79.3 µM 1.08E-6 3 1.93E-6
9 SGTC_423 5-fluorouracil 4.61 457.0 µM 1.11E-6 exosome 11 1.99E-6
10 SGTC_2681 menadione 4.54 3.2 µM 1.62E-6 superoxide 25 2.84E-6
11 SGTC_1784 st039334 4.40 36.3 µM 3.21E-6 12 5.44E-6
12 SGTC_1477 0139-0234 3.88 16.0 µM 3.55E-5 8 5.33E-5
13 SGTC_62 0180-0423 3.86 3.2 µM 3.77E-5 60S ribosome export 21 5.64E-5
14 SGTC_1006 4099-6547 3.82 255.0 µM 4.55E-5 25 6.74E-5
15 SGTC_1958 st076513 3.73 41.9 µM 6.47E-5 60S ribosome export 36 9.42E-5
16 SGTC_433 pimozide 3.69 108.0 µM 7.80E-5 21 1.12E-4
17 SGTC_1021 4476-0760 3.64 85.3 µM 9.48E-5 37 1.35E-4
18 SGTC_931 2812-0076 3.63 566.0 µM 9.86E-5 33 1.41E-4
19 SGTC_2950 9072895 3.60 21.5 µM 1.14E-4 56 1.61E-4
20 SGTC_1550 gossypolone 3.57 36.6 µM 1.29E-4 20 1.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.26E-11 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.106 8.11E-10 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.098 1.50E-8 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.091 1.42E-7 YLR438W CAR2 hom L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
0.090 1.62E-7 YBR018C GAL7 hom Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
0.086 5.50E-7 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.086 7.03E-7 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.081 2.88E-6 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.080 3.11E-6 YMR245W_d YMR245W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.90E-6 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.079 4.91E-6 YOL131W_p YOL131W_p hom Putative protein of unknown function
0.075 1.35E-5 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
0.075 1.52E-5 YER080W AIM9 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.074 1.93E-5 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.071 3.64E-5 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication