YNL161W / CBK1

Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL161W / CBK1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-2.80|P-value:8.73E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-2.94|P-value:5.04E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.09|P-value:2.70E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.78|P-value:1.18E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.86|P-value:7.33E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.14|P-value:4.24E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.26|P-value:9.12E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:3.39|P-value:7.01E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:5.57|P-value:2.08E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.17|P-value:1.91E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:2.81|P-value:8.02E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.70|P-value:1.70E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:2.76|P-value:9.70E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-2.92|P-value:5.40E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.30|P-value:7.04E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:2.76|P-value:9.51E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.72|P-value:1.50E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.33|P-value:9.08E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.00|P-value:3.73E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.41|P-value:6.42E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:-4.28|P-value:8.35E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.44|P-value:3.30E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:2.94|P-value:4.81E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.07|P-value:2.85E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.11|P-value:2.40E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.97|P-value:4.37E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-4.05|P-value:2.89E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.95|P-value:4.86E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.66|P-value:4.68E-18 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.14|P-value:2.08E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.08|P-value:2.71E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.91|P-value:5.73E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.28|P-value:7.61E-7 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-2.80|P-value:8.74E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:6.42|P-value:2.99E-13 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.35|P-value:5.55E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.26|P-value:9.32E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.68|P-value:1.82E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.87|P-value:6.31E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-5.87|P-value:2.42E-11 ID:SGTC_1672|Compound:st016598|FD-Score:-2.95|P-value:4.77E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.39|P-value:7.25E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-2.77|P-value:9.78E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.05|P-value:3.09E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.87|P-value:6.68E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.48|P-value:4.72E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.48|P-value:4.89E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-4.34|P-value:6.00E-7 ID:SGTC_2113|Compound:5491891|FD-Score:3.16|P-value:1.95E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.09|P-value:2.20E-6 ID:SGTC_2185|Compound:6113692|FD-Score:3.66|P-value:2.01E-5 ID:SGTC_2368|Compound:9071271|FD-Score:2.95|P-value:4.65E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.79|P-value:1.02E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.43|P-value:5.79E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.43|P-value:5.95E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.82|P-value:9.34E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.55|P-value:3.40E-5 ID:SGTC_2646|Compound:retinol|FD-Score:2.83|P-value:7.50E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-2.94|P-value:5.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.41|P-value:6.39E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.46|P-value:5.02E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-2.89|P-value:6.11E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:2.86|P-value:6.61E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.15|P-value:2.07E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.19|P-value:1.67E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-5.73|P-value:6.88E-11 ID:SGTC_2940|Compound:9060638|FD-Score:-3.95|P-value:4.83E-6 ID:SGTC_2969|Compound:9091408|FD-Score:-2.81|P-value:8.15E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-2.82|P-value:8.00E-4 ID:SGTC_3049|Compound:9092223|FD-Score:5.02|P-value:9.02E-9 ID:SGTC_3062|Compound:9077494|FD-Score:-7.36|P-value:8.18E-17 ID:SGTC_3154|Compound:9100113|FD-Score:-2.89|P-value:6.00E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.01|P-value:3.55E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.79|P-value:8.58E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:-2.80|P-value:8.73E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-2.94|P-value:5.04E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.09|P-value:2.70E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.78|P-value:1.18E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.86|P-value:7.33E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.14|P-value:4.24E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.26|P-value:9.12E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:3.39|P-value:7.01E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:5.57|P-value:2.08E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.17|P-value:1.91E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:2.81|P-value:8.02E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.70|P-value:1.70E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:2.76|P-value:9.70E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-2.92|P-value:5.40E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.30|P-value:7.04E-7 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:2.76|P-value:9.51E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.72|P-value:1.50E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.33|P-value:9.08E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:3.00|P-value:3.73E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.41|P-value:6.42E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:-4.28|P-value:8.35E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.44|P-value:3.30E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:2.94|P-value:4.81E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.07|P-value:2.85E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.11|P-value:2.40E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.97|P-value:4.37E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-4.05|P-value:2.89E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.95|P-value:4.86E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.66|P-value:4.68E-18 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.14|P-value:2.08E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.08|P-value:2.71E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.91|P-value:5.73E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.28|P-value:7.61E-7 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-2.80|P-value:8.74E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:6.42|P-value:2.99E-13 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.35|P-value:5.55E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.26|P-value:9.32E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.99|P-value:3.93E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.68|P-value:1.82E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.87|P-value:6.31E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-5.87|P-value:2.42E-11 ID:SGTC_1672|Compound:st016598|FD-Score:-2.95|P-value:4.77E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.39|P-value:7.25E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-2.77|P-value:9.78E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.05|P-value:3.09E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.87|P-value:6.68E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.48|P-value:4.72E-5 ID:SGTC_1941|Compound:st076221|FD-Score:-3.48|P-value:4.89E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-4.34|P-value:6.00E-7 ID:SGTC_2113|Compound:5491891|FD-Score:3.16|P-value:1.95E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.09|P-value:2.20E-6 ID:SGTC_2185|Compound:6113692|FD-Score:3.66|P-value:2.01E-5 ID:SGTC_2368|Compound:9071271|FD-Score:2.95|P-value:4.65E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.79|P-value:1.02E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.43|P-value:5.79E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.43|P-value:5.95E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.82|P-value:9.34E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.55|P-value:3.40E-5 ID:SGTC_2646|Compound:retinol|FD-Score:2.83|P-value:7.50E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-2.94|P-value:5.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.41|P-value:6.39E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.46|P-value:5.02E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-2.89|P-value:6.11E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:2.86|P-value:6.61E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.15|P-value:2.07E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.19|P-value:1.67E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-5.73|P-value:6.88E-11 ID:SGTC_2940|Compound:9060638|FD-Score:-3.95|P-value:4.83E-6 ID:SGTC_2969|Compound:9091408|FD-Score:-2.81|P-value:8.15E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-2.82|P-value:8.00E-4 ID:SGTC_3049|Compound:9092223|FD-Score:5.02|P-value:9.02E-9 ID:SGTC_3062|Compound:9077494|FD-Score:-7.36|P-value:8.18E-17 ID:SGTC_3154|Compound:9100113|FD-Score:-2.89|P-value:6.00E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.01|P-value:3.55E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.79|P-value:8.58E-4

Top fitness defect scores for YNL161W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1313 1220-0047 6.42 237.0 µM 2.99E-13 2 6.93E-11 0.96
2 SGTC_171 k064-0041 5.57 9.7 µM 2.08E-10 heme requiring 9 1.29E-8 0.57
3 SGTC_3049 9092223 5.02 49.5 µM 9.02E-9 1 2.64E-7 0.50
4 SGTC_398 bronopol 4.30 33.3 µM 7.04E-7 RNA processing & uracil transport 7 8.64E-6 0.09
5 SGTC_1174 0739-0097 4.28 51.1 µM 7.61E-7 redox potentiating 3 9.20E-6 0.13
6 SGTC_2164 5685496 4.09 200.0 µM 2.20E-6 8 2.16E-5 0.45
7 SGTC_117 lucigenin 3.86 22.1 µM 7.33E-6 redox potentiating 10 5.67E-5 0.17
8 SGTC_2432 5630864 3.79 12.2 µM 1.02E-5 5 7.40E-5 0.09
9 SGTC_431 k089-0097 3.72 107.0 µM 1.50E-5 iron homeostasis 18 1.00E-4 0.25
10 SGTC_1559 coumarin 343 3.68 70.1 µM 1.82E-5 2 1.18E-4 0.04
11 SGTC_2185 6113692 3.66 200.0 µM 2.01E-5 ergosterol biosynthesis 9 1.27E-4 0.01
12 SGTC_2627 acetyl isogambogic acid 3.55 100.0 µM 3.40E-5 TSC3-RPN4 8 1.95E-4 7.73E-4
13 SGTC_1919 st067113 3.48 52.3 µM 4.72E-5 TSC3-RPN4 13 2.53E-4 0.09
14 SGTC_2758 dehydroepiandrosterone 3.46 69.3 µM 5.02E-5 12 2.66E-4 0.03
15 SGTC_2435 5706476 3.43 10.6 µM 5.79E-5 5 2.98E-4 0.35
16 SGTC_2497 7-hydroxyflavone 3.43 100.0 µM 5.95E-5 5 3.05E-4 0.07
17 SGTC_2675 theaflavin digallate 3.41 100.0 µM 6.39E-5 iron homeostasis 13 3.23E-4 0.08
18 SGTC_734 2023-0417 3.41 80.0 µM 6.42E-5 ergosterol biosynthesis 15 3.24E-4 0.04
19 SGTC_166 k072-0058 3.39 166.4 µM 7.01E-5 DNA intercalators 11 3.48E-4 0.14
20 SGTC_551 k048-0028 3.33 34.9 µM 9.08E-5 17 4.29E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 5.31E-32 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.196 2.04E-30 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.195 3.54E-30 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.190 1.13E-28 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.175 1.95E-24 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
0.168 1.17E-22 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.167 2.14E-22 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.167 2.48E-22 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.162 3.91E-21 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.157 5.22E-20 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.155 1.74E-19 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.150 1.96E-18 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.150 3.06E-18 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.148 7.91E-18 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.148 8.78E-18 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155