YNL168C_p / FMP41

Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL168C / FMP41

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.38|P-value:1.29E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-2.99|P-value:6.16E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:2.96|P-value:6.96E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.24|P-value:2.26E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.55|P-value:6.21E-5 ID:SGTC_251|Compound:melphalan|FD-Score:-3.10|P-value:4.01E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.01|P-value:5.64E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.32|P-value:1.64E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-4.09|P-value:4.94E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-2.86|P-value:9.74E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-2.95|P-value:7.18E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.21|P-value:2.59E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.11|P-value:3.95E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.20|P-value:2.81E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:3.12|P-value:3.73E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.03|P-value:5.20E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.88|P-value:1.39E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.37|P-value:1.15E-6 ID:SGTC_880|Compound:0833-0487|FD-Score:-4.82|P-value:9.03E-8 ID:SGTC_985|Compound:1493-0307|FD-Score:2.99|P-value:6.07E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.93|P-value:7.59E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:5.03|P-value:2.64E-8 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.54|P-value:6.59E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.68|P-value:3.35E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-2.94|P-value:7.37E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-2.86|P-value:9.69E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.98|P-value:8.31E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.61|P-value:4.80E-5 ID:SGTC_1684|Compound:st024538|FD-Score:-3.30|P-value:1.77E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.24|P-value:2.32E-4 ID:SGTC_2350|Compound:9023895|FD-Score:6.15|P-value:1.48E-11 ID:SGTC_2364|Compound:9055074|FD-Score:4.23|P-value:2.45E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.07|P-value:4.59E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-4.15|P-value:3.52E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.64|P-value:4.13E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.88|P-value:9.37E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:5.27|P-value:6.14E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:4.63|P-value:2.87E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.06|P-value:5.75E-6 ID:SGTC_2841|Compound:9004761|FD-Score:3.30|P-value:1.83E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.99|P-value:6.19E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.26|P-value:2.14E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.46|P-value:9.29E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.88|P-value:1.35E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.05|P-value:4.96E-4 ID:SGTC_3284|Compound:9108171|FD-Score:6.13|P-value:1.78E-11 ID:SGTC_3285|Compound:9112818|FD-Score:-2.86|P-value:9.79E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.02|P-value:5.50E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.38|P-value:1.29E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-2.99|P-value:6.16E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:2.96|P-value:6.96E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.24|P-value:2.26E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.55|P-value:6.21E-5 ID:SGTC_251|Compound:melphalan|FD-Score:-3.10|P-value:4.01E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.01|P-value:5.64E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.32|P-value:1.64E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-4.09|P-value:4.94E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-2.86|P-value:9.74E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-2.95|P-value:7.18E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.21|P-value:2.59E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.11|P-value:3.95E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.20|P-value:2.81E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:3.12|P-value:3.73E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.03|P-value:5.20E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.88|P-value:1.39E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.37|P-value:1.15E-6 ID:SGTC_880|Compound:0833-0487|FD-Score:-4.82|P-value:9.03E-8 ID:SGTC_985|Compound:1493-0307|FD-Score:2.99|P-value:6.07E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.93|P-value:7.59E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:5.03|P-value:2.64E-8 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.54|P-value:6.59E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.68|P-value:3.35E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:-2.94|P-value:7.37E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-2.86|P-value:9.69E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.98|P-value:8.31E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.61|P-value:4.80E-5 ID:SGTC_1684|Compound:st024538|FD-Score:-3.30|P-value:1.77E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.24|P-value:2.32E-4 ID:SGTC_2350|Compound:9023895|FD-Score:6.15|P-value:1.48E-11 ID:SGTC_2364|Compound:9055074|FD-Score:4.23|P-value:2.45E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.07|P-value:4.59E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-4.15|P-value:3.52E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.64|P-value:4.13E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.88|P-value:9.37E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:5.27|P-value:6.14E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:4.63|P-value:2.87E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.06|P-value:5.75E-6 ID:SGTC_2841|Compound:9004761|FD-Score:3.30|P-value:1.83E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.99|P-value:6.19E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.26|P-value:2.14E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.96|P-value:6.90E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.43|P-value:1.06E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.46|P-value:9.29E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.88|P-value:1.35E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.05|P-value:4.96E-4 ID:SGTC_3284|Compound:9108171|FD-Score:6.13|P-value:1.78E-11 ID:SGTC_3285|Compound:9112818|FD-Score:-2.86|P-value:9.79E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.02|P-value:5.50E-4

Top fitness defect scores for YNL168C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2350 9023895 6.15 38.9 µM 1.48E-11 ergosterol biosynthesis 10 3.87E-10
2 SGTC_3284 9108171 6.13 64.9 µM 1.78E-11 5 4.53E-10
3 SGTC_2736 butenafine 5.27 14.7 µM 6.14E-9 12 6.85E-8
4 SGTC_1056 3448-1962 5.03 115.0 µM 2.64E-8 amide catabolism 9 2.40E-7
5 SGTC_2739 tacrine 4.63 100.9 µM 2.87E-7 heme requiring 8 1.87E-6
6 SGTC_135 0933-0004 4.24 26.4 µM 2.26E-6 60S ribosome export 16 1.10E-5
7 SGTC_2364 9055074 4.23 200.0 µM 2.45E-6 15 1.18E-5
8 SGTC_666 0272-0154 4.20 136.0 µM 2.81E-6 cell wall 47 1.33E-5
9 SGTC_2763 lisinopril 4.06 49.3 µM 5.75E-6 12 2.47E-5
10 SGTC_1357 1503-1303 3.98 39.5 µM 8.31E-6 33 3.39E-5
11 SGTC_3164 9100705 3.88 49.5 µM 1.35E-5 4 5.16E-5
12 SGTC_867 0518-0118 3.88 155.0 µM 1.39E-5 DNA intercalators 22 5.28E-5
13 SGTC_1364 1653-0028 3.61 37.6 µM 4.80E-5 35 1.54E-4
14 SGTC_1059 3448-6867 3.54 171.0 µM 6.59E-5 20 2.02E-4
15 SGTC_3147 9097027 3.46 49.5 µM 9.29E-5 41 2.72E-4
16 SGTC_3093 9117344 3.43 49.5 µM 1.06E-4 60S ribosome export 33 3.05E-4
17 SGTC_30 5-(2-thienylidene)-Rhodanine 3.38 28.7 µM 1.29E-4 12 3.61E-4
18 SGTC_412 gemfibrozil 3.32 100.0 µM 1.64E-4 DNA intercalators 19 4.44E-4
19 SGTC_2841 9004761 3.30 39.0 µM 1.83E-4 amide catabolism 60 4.89E-4
20 SGTC_2989 9073649 3.26 71.4 µM 2.14E-4 75 5.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.12E-9 YGL216W KIP3 hom Kinesin-related motor protein involved in mitotic spindle positioning
0.098 1.34E-8 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 4.84E-6 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.078 6.28E-6 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.074 1.60E-5 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
0.074 1.83E-5 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.072 3.09E-5 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.072 3.20E-5 YOR137C SIA1 hom Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
0.072 3.25E-5 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.069 6.68E-5 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
0.069 7.05E-5 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.068 7.41E-5 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.068 8.03E-5 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.067 9.78E-5 YOR239W ABP140 hom AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
0.067 1.14E-4 YPR178W PRP4 het Splicing factor, component of the U4/U6-U5 snRNP complex