YNL170W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL170W / YNL170W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.62|P-value:4.71E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-5.17|P-value:1.95E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:3.84|P-value:2.28E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.86|P-value:2.12E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.92|P-value:3.68E-8 ID:SGTC_183|Compound:3914-0051|FD-Score:4.26|P-value:5.08E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:6.33|P-value:4.54E-9 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.83|P-value:2.36E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:7.12|P-value:5.27E-11 ID:SGTC_314|Compound:1671-0008|FD-Score:4.23|P-value:5.68E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.52|P-value:6.46E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.78|P-value:6.82E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:3.51|P-value:6.64E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:5.69|P-value:1.13E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.62|P-value:4.79E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:5.21|P-value:1.07E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:4.45|P-value:2.47E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:4.59|P-value:1.44E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.77|P-value:2.91E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.20|P-value:6.51E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.25|P-value:5.38E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:5.77|P-value:7.67E-8 ID:SGTC_928|Compound:2764-0428|FD-Score:4.79|P-value:6.48E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:5.58|P-value:1.94E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.26|P-value:5.05E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.68|P-value:5.29E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.13|P-value:8.31E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.61|P-value:4.94E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.59|P-value:1.45E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.41|P-value:2.92E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.86|P-value:2.12E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.48|P-value:7.39E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:7.46|P-value:6.54E-12 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.37|P-value:3.61E-9 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.41|P-value:2.87E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.31|P-value:4.19E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.35|P-value:3.62E-5 ID:SGTC_1661|Compound:st013063|FD-Score:5.06|P-value:2.10E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.43|P-value:2.75E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.85|P-value:2.20E-4 ID:SGTC_2181|Compound:6316240|FD-Score:4.89|P-value:4.27E-6 ID:SGTC_2270|Compound:7924575|FD-Score:6.19|P-value:9.61E-9 ID:SGTC_2276|Compound:7947513|FD-Score:6.36|P-value:3.81E-9 ID:SGTC_2288|Compound:7946289|FD-Score:4.85|P-value:5.14E-6 ID:SGTC_2365|Compound:9042475|FD-Score:6.28|P-value:5.79E-9 ID:SGTC_2452|Compound:5863136|FD-Score:5.20|P-value:1.10E-6 ID:SGTC_2460|Compound:5552655|FD-Score:4.10|P-value:9.37E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.78|P-value:2.80E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.50|P-value:2.10E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.05|P-value:2.17E-6 ID:SGTC_2601|Compound:securinine|FD-Score:3.52|P-value:6.42E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.58|P-value:5.44E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.06|P-value:1.51E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.94|P-value:1.61E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.68|P-value:5.32E-4 ID:SGTC_3030|Compound:9087619|FD-Score:6.87|P-value:2.20E-10 ID:SGTC_3132|Compound:9126706|FD-Score:6.44|P-value:2.45E-9 ID:SGTC_3148|Compound:9097893|FD-Score:3.45|P-value:8.03E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.47|P-value:7.61E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.04|P-value:1.15E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.11|P-value:1.69E-6 ID:SGTC_3307|Compound:9126885|FD-Score:4.10|P-value:9.20E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.62|P-value:4.71E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-5.17|P-value:1.95E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:3.84|P-value:2.28E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.86|P-value:2.12E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.92|P-value:3.68E-8 ID:SGTC_183|Compound:3914-0051|FD-Score:4.26|P-value:5.08E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:6.33|P-value:4.54E-9 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.83|P-value:2.36E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:7.12|P-value:5.27E-11 ID:SGTC_314|Compound:1671-0008|FD-Score:4.23|P-value:5.68E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.52|P-value:6.46E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.78|P-value:6.82E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:3.51|P-value:6.64E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:5.69|P-value:1.13E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.62|P-value:4.79E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:5.21|P-value:1.07E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:4.45|P-value:2.47E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:4.59|P-value:1.44E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.77|P-value:2.91E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.20|P-value:6.51E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.25|P-value:5.38E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:5.77|P-value:7.67E-8 ID:SGTC_928|Compound:2764-0428|FD-Score:4.79|P-value:6.48E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:5.58|P-value:1.94E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:4.26|P-value:5.05E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.68|P-value:5.29E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.13|P-value:8.31E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.61|P-value:4.94E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.59|P-value:1.45E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.41|P-value:2.92E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.07|P-value:1.03E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.86|P-value:2.12E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.48|P-value:7.39E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:7.46|P-value:6.54E-12 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.37|P-value:3.61E-9 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.41|P-value:2.87E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.31|P-value:4.19E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.35|P-value:3.62E-5 ID:SGTC_1661|Compound:st013063|FD-Score:5.06|P-value:2.10E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.43|P-value:2.75E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.85|P-value:2.20E-4 ID:SGTC_2181|Compound:6316240|FD-Score:4.89|P-value:4.27E-6 ID:SGTC_2270|Compound:7924575|FD-Score:6.19|P-value:9.61E-9 ID:SGTC_2276|Compound:7947513|FD-Score:6.36|P-value:3.81E-9 ID:SGTC_2288|Compound:7946289|FD-Score:4.85|P-value:5.14E-6 ID:SGTC_2365|Compound:9042475|FD-Score:6.28|P-value:5.79E-9 ID:SGTC_2452|Compound:5863136|FD-Score:5.20|P-value:1.10E-6 ID:SGTC_2460|Compound:5552655|FD-Score:4.10|P-value:9.37E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.78|P-value:2.80E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.50|P-value:2.10E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:5.05|P-value:2.17E-6 ID:SGTC_2601|Compound:securinine|FD-Score:3.52|P-value:6.42E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.58|P-value:5.44E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.06|P-value:1.51E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.94|P-value:1.61E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.68|P-value:5.32E-4 ID:SGTC_3030|Compound:9087619|FD-Score:6.87|P-value:2.20E-10 ID:SGTC_3132|Compound:9126706|FD-Score:6.44|P-value:2.45E-9 ID:SGTC_3148|Compound:9097893|FD-Score:3.45|P-value:8.03E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.47|P-value:7.61E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.04|P-value:1.15E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.11|P-value:1.69E-6 ID:SGTC_3307|Compound:9126885|FD-Score:4.10|P-value:9.20E-5

Top fitness defect scores for YNL170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1386 3228-0095 7.46 33.8 µM 6.54E-12 2 4.34E-14
2 SGTC_259 usnic acid 7.12 108.9 µM 5.27E-11 3 5.51E-13
3 SGTC_3030 9087619 6.87 49.5 µM 2.20E-10 1 3.13E-12
4 SGTC_3132 9126706 6.44 49.5 µM 2.45E-9 3 5.88E-11
5 SGTC_1453 4237-0541 6.37 195.0 µM 3.61E-9 heme biosynthesis & mitochondrial translocase 4 9.44E-11
6 SGTC_2276 7947513 6.36 42.1 µM 3.81E-9 3 1.01E-10
7 SGTC_236 1509-0011 6.33 5.3 µM 4.54E-9 286 1.25E-10
8 SGTC_2365 9042475 6.28 200.0 µM 5.79E-9 8 1.68E-10
9 SGTC_2270 7924575 6.19 90.9 µM 9.61E-9 RPP1 & pyrimidine depletion 1 3.10E-10
10 SGTC_165 k038-0023 5.92 64.4 µM 3.68E-8 ubiquinone biosynthesis & proteasome 23 1.59E-9
11 SGTC_869 0564-0080 5.77 44.1 µM 7.67E-8 4 3.87E-9
12 SGTC_696 1560-0013 5.69 611.0 µM 1.13E-7 7 6.20E-9
13 SGTC_931 2812-0076 5.58 566.0 µM 1.94E-7 4 1.19E-8
14 SGTC_745 0469-0705 5.21 296.0 µM 1.07E-6 mitochondrial processes 6 9.46E-8
15 SGTC_2452 5863136 5.20 48.4 µM 1.10E-6 8 9.77E-8
16 SGTC_3282 9108498 5.11 15.5 µM 1.69E-6 13 1.65E-7
17 SGTC_1661 st013063 5.06 9.7 µM 2.10E-6 14 2.14E-7
18 SGTC_2533 agelasine 5.05 13.7 µM 2.17E-6 ERG2 22 2.22E-7
19 SGTC_2181 6316240 4.89 54.3 µM 4.27E-6 9 5.05E-7
20 SGTC_2288 7946289 4.85 167.3 µM 5.14E-6 12 6.32E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.87E-14 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.127 1.88E-13 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.125 4.03E-13 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.122 1.07E-12 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.118 7.89E-12 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.113 6.23E-11 YIL125W KGD1 hom Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
0.113 6.53E-11 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.111 1.30E-10 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.110 1.78E-10 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.109 2.82E-10 YDL068W_d YDL068W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.107 5.93E-10 YPR046W MCM16 hom Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
0.106 6.99E-10 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.103 1.89E-9 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.102 2.76E-9 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.102 2.96E-9 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p