YNL173C / MDG1

Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL173C / MDG1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.48|P-value:4.52E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.06|P-value:5.33E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.36|P-value:6.91E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.69|P-value:2.15E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.25|P-value:9.89E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.70|P-value:2.14E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.89|P-value:1.04E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.56|P-value:3.51E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.85|P-value:1.48E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:4.94|P-value:1.20E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:3.56|P-value:3.48E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.49|P-value:9.37E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:4.40|P-value:1.35E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.52|P-value:3.93E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.61|P-value:2.91E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:5.67|P-value:3.10E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.87|P-value:1.67E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.37|P-value:6.70E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.48|P-value:4.60E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.29|P-value:8.69E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.25|P-value:9.97E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.78|P-value:1.56E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.62|P-value:2.80E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.42|P-value:5.55E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.91|P-value:9.57E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.42|P-value:5.67E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.27|P-value:9.23E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.66|P-value:2.40E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.94|P-value:8.68E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.57|P-value:3.30E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:6.14|P-value:2.22E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.44|P-value:1.13E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.47|P-value:4.74E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-7.78|P-value:3.60E-14 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.14|P-value:3.29E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-7.35|P-value:7.87E-13 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:9.25|P-value:4.36E-19 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.27|P-value:8.02E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.51|P-value:3.51E-4 ID:SGTC_2789|Compound:5281112|FD-Score:5.99|P-value:5.26E-9 ID:SGTC_2843|Compound:9000894|FD-Score:-3.35|P-value:6.08E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-3.64|P-value:2.21E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.27|P-value:8.03E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.57|P-value:3.38E-4 ID:SGTC_3159|Compound:9100096|FD-Score:5.00|P-value:9.09E-7 ID:SGTC_20|Compound:0481-0013|FD-Score:3.48|P-value:4.52E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.06|P-value:5.33E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.36|P-value:6.91E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.69|P-value:2.15E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.25|P-value:9.89E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.70|P-value:2.14E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.89|P-value:1.04E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.56|P-value:3.51E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.85|P-value:1.48E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:4.94|P-value:1.20E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:3.56|P-value:3.48E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.49|P-value:9.37E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:4.40|P-value:1.35E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.52|P-value:3.93E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.61|P-value:2.91E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:5.67|P-value:3.10E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.87|P-value:1.67E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.37|P-value:6.70E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.48|P-value:4.60E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.29|P-value:8.69E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.25|P-value:9.97E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.78|P-value:1.56E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.62|P-value:2.80E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.59|P-value:3.07E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.42|P-value:5.55E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.91|P-value:9.57E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.42|P-value:5.67E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.27|P-value:9.23E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.66|P-value:2.40E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.94|P-value:8.68E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.57|P-value:3.30E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:6.14|P-value:2.22E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.44|P-value:1.13E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.47|P-value:4.74E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-7.78|P-value:3.60E-14 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-4.14|P-value:3.29E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-7.35|P-value:7.87E-13 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:9.25|P-value:4.36E-19 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.27|P-value:8.02E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.51|P-value:3.51E-4 ID:SGTC_2789|Compound:5281112|FD-Score:5.99|P-value:5.26E-9 ID:SGTC_2843|Compound:9000894|FD-Score:-3.35|P-value:6.08E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-3.64|P-value:2.21E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.27|P-value:8.03E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.57|P-value:3.38E-4 ID:SGTC_3159|Compound:9100096|FD-Score:5.00|P-value:9.09E-7

Top fitness defect scores for YNL173C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2627 acetyl isogambogic acid 9.25 100.0 µM 4.36E-19 TSC3-RPN4 5 1.09E-20
2 SGTC_2507 purpurin 6.14 79.7 µM 2.22E-9 copper-dependent oxidative stress 10 4.10E-10
3 SGTC_2789 5281112 5.99 71.4 µM 5.26E-9 6 1.05E-9
4 SGTC_984 1492-0255 5.67 2.9 µM 3.10E-8 SWF1 & branched chain AA biosynthesis 11 7.23E-9
5 SGTC_3159 9100096 5.00 49.5 µM 9.09E-7 8 2.87E-7
6 SGTC_904 1141-0088 4.94 396.0 µM 1.20E-6 7 3.88E-7
7 SGTC_1119 parthenolide 4.87 318.5 nM 1.67E-6 TSC3-RPN4 22 5.58E-7
8 SGTC_958 1222-0007 4.49 33.0 µM 9.37E-6 17 3.64E-6
9 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.44 66.7 µM 1.13E-5 8 4.47E-6
10 SGTC_977 1348-1378 4.40 135.0 µM 1.35E-5 14 5.42E-6
11 SGTC_122 0236-0016 4.06 402.4 µM 5.33E-5 RNA processing & uracil transport 29 2.42E-5
12 SGTC_2952 9073731 4.01 13.8 µM 6.63E-5 tubulin folding & SWR complex 41 3.06E-5
13 SGTC_2135 5326629 3.94 150.4 µM 8.68E-5 RPP1 & pyrimidine depletion 27 4.11E-5
14 SGTC_1494 4358-1428 3.91 177.0 µM 9.57E-5 26 4.57E-5
15 SGTC_804 1595-0054 3.89 20.9 µM 1.04E-4 sphingolipid biosynthesis & PDR1 37 5.01E-5
16 SGTC_1392 3455-1037 3.78 33.9 µM 1.56E-4 19 7.75E-5
17 SGTC_1044 1222-0021 3.76 1.8 µM 1.68E-4 heme biosynthesis & mitochondrial translocase 44 8.44E-5
18 SGTC_801 0866-0028 3.70 10.1 µM 2.14E-4 37 1.10E-4
19 SGTC_532 1548-0774 3.69 215.0 µM 2.15E-4 28 1.10E-4
20 SGTC_1952 st077036 3.66 64.1 µM 2.40E-4 43 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 7.40E-17 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.108 3.80E-10 YOR161C-C_p YOR161C-C_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.094 4.82E-8 YIL158W AIM20 hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.093 7.76E-8 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.091 1.17E-7 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.087 3.88E-7 YPL103C FMP30 hom Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D
0.085 8.05E-7 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.084 1.14E-6 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.082 2.03E-6 YMR177W MMT1 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
0.081 2.58E-6 YER173W RAD24 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
0.078 6.50E-6 YNL279W PRM1 hom Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
0.075 1.20E-5 YDR393W SHE9 hom Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
0.075 1.43E-5 YOL126C MDH2 hom Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.074 1.71E-5 YOR099W KTR1 hom Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.073 2.16E-5 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene