YNL175C / NOP13

Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL175C / NOP13

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.86|P-value:1.97E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:3.62|P-value:3.00E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.34|P-value:7.93E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.78|P-value:1.69E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.22|P-value:9.94E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.52|P-value:3.67E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.27|P-value:9.78E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.28|P-value:9.53E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:6.81|P-value:4.82E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.27|P-value:2.58E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.81|P-value:1.51E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.70|P-value:4.07E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.48|P-value:4.93E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.83|P-value:2.30E-6 ID:SGTC_843|Compound:0310-0051|FD-Score:4.51|P-value:9.29E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.14|P-value:3.74E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.79|P-value:1.64E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.39|P-value:5.80E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.76|P-value:1.83E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.72|P-value:2.13E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.39|P-value:1.55E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.41|P-value:1.40E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.67|P-value:2.54E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.42|P-value:5.93E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.70|P-value:9.52E-11 ID:SGTC_1516|Compound:st013856|FD-Score:-3.96|P-value:7.40E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_1729|Compound:st035615|FD-Score:7.41|P-value:9.52E-13 ID:SGTC_1786|Compound:berberine|FD-Score:5.21|P-value:3.83E-7 ID:SGTC_1881|Compound:5652484|FD-Score:-3.70|P-value:1.96E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.73|P-value:3.64E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.36|P-value:1.77E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-4.16|P-value:3.46E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.99|P-value:7.72E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.36|P-value:7.22E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.52|P-value:4.32E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.02|P-value:6.98E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.56|P-value:7.49E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.85|P-value:1.32E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.69|P-value:4.27E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.59|P-value:3.38E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.40|P-value:6.38E-4 ID:SGTC_2884|Compound:9058502|FD-Score:4.04|P-value:6.29E-5 ID:SGTC_2885|Compound:9057732|FD-Score:3.53|P-value:4.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.04|P-value:6.48E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.02|P-value:5.80E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.22|P-value:3.21E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.03|P-value:6.61E-5 ID:SGTC_3158|Compound:9100007|FD-Score:4.12|P-value:4.69E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.34|P-value:6.79E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.86|P-value:1.97E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:3.62|P-value:3.00E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.34|P-value:7.93E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.78|P-value:1.69E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.22|P-value:9.94E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.52|P-value:3.67E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.27|P-value:9.78E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.28|P-value:9.53E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:6.81|P-value:4.82E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.27|P-value:2.58E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.81|P-value:1.51E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.70|P-value:4.07E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.48|P-value:4.93E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.83|P-value:2.30E-6 ID:SGTC_843|Compound:0310-0051|FD-Score:4.51|P-value:9.29E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.14|P-value:3.74E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.79|P-value:1.64E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.39|P-value:5.80E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.76|P-value:1.83E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.72|P-value:2.13E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.39|P-value:1.55E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.41|P-value:1.40E-7 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.67|P-value:2.54E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.42|P-value:5.93E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.70|P-value:9.52E-11 ID:SGTC_1516|Compound:st013856|FD-Score:-3.96|P-value:7.40E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_1729|Compound:st035615|FD-Score:7.41|P-value:9.52E-13 ID:SGTC_1786|Compound:berberine|FD-Score:5.21|P-value:3.83E-7 ID:SGTC_1881|Compound:5652484|FD-Score:-3.70|P-value:1.96E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.73|P-value:3.64E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.36|P-value:1.77E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-4.16|P-value:3.46E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.99|P-value:7.72E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.36|P-value:7.22E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.52|P-value:4.32E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.02|P-value:6.98E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:4.56|P-value:7.49E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.85|P-value:1.32E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.69|P-value:4.27E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.59|P-value:3.38E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.40|P-value:6.38E-4 ID:SGTC_2884|Compound:9058502|FD-Score:4.04|P-value:6.29E-5 ID:SGTC_2885|Compound:9057732|FD-Score:3.53|P-value:4.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.04|P-value:6.48E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.02|P-value:5.80E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.22|P-value:3.21E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.51|P-value:4.41E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.03|P-value:6.61E-5 ID:SGTC_3158|Compound:9100007|FD-Score:4.12|P-value:4.69E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.34|P-value:6.79E-4

Top fitness defect scores for YNL175C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1729 st035615 7.41 46.0 µM 9.52E-13 5 6.30E-14
2 SGTC_331 k048-0133 6.81 24.5 µM 4.82E-11 RSC & ERG11 1 4.77E-12
3 SGTC_1514 1189-1591 6.70 158.0 µM 9.52E-11 8 1.01E-11
4 SGTC_1368 1852-0141 5.41 284.0 µM 1.40E-7 ERG2 19 3.13E-8
5 SGTC_1786 berberine 5.21 21.6 µM 3.83E-7 60S ribosome export 13 9.50E-8
6 SGTC_58 0957-0393 4.86 9.0 µM 1.97E-6 cell wall 298 5.78E-7
7 SGTC_572 0960-0087 4.83 17.7 µM 2.30E-6 8 6.84E-7
8 SGTC_2028 5153890 4.73 36.4 µM 3.64E-6 cell wall signaling 21 1.13E-6
9 SGTC_568 1193-0097 4.70 7.5 µM 4.07E-6 ERAD & cell cycle 102 1.28E-6
10 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.69 100.0 µM 4.27E-6 12 1.35E-6
11 SGTC_2557 derrustone 4.56 83.8 µM 7.49E-6 18 2.51E-6
12 SGTC_843 0310-0051 4.51 143.0 µM 9.29E-6 7 3.19E-6
13 SGTC_1269 0831-0796 4.39 3.0 µM 1.55E-5 60S ribosome export 9 5.59E-6
14 SGTC_160 3453-0671 4.39 289.7 µM 1.56E-5 29 5.62E-6
15 SGTC_2038 4100038 4.36 31.0 µM 1.77E-5 plasma membrane duress 36 6.48E-6
16 SGTC_457 grayanotoxin iii 4.27 135.0 µM 2.58E-5 52 9.81E-6
17 SGTC_3072 9116419 4.22 49.5 µM 3.21E-5 ERG2 10 1.25E-5
18 SGTC_3158 9100007 4.12 49.5 µM 4.69E-5 16 1.90E-5
19 SGTC_1527 coumarin 4.11 137.0 µM 4.93E-5 21 2.00E-5
20 SGTC_2884 9058502 4.04 52.0 µM 6.29E-5 26 2.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.40E-18 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.136 2.97E-15 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.113 4.65E-11 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.104 1.67E-9 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.103 2.25E-9 YDR150W NUM1 hom Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
0.102 2.94E-9 YBR208C DUR1,2 hom Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
0.097 1.86E-8 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.096 2.83E-8 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.095 3.13E-8 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.095 3.28E-8 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.095 3.76E-8 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.095 3.88E-8 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.093 6.15E-8 YPR184W GDB1 hom Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress
0.093 7.43E-8 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.091 1.41E-7 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication