HIPHOP chemogenomics database
YNL175C / NOP13 
Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YNL175C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.151 | 1.40E-18 | YNL179C_d | YNL179C_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance |
| 0.136 | 2.97E-15 | YGR058W | PEF1 | hom | Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly |
| 0.113 | 4.65E-11 | YKL115C_d | YKL115C_d | hom | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 |
| 0.104 | 1.67E-9 | YNL299W | TRF5 | hom | Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p |
| 0.103 | 2.25E-9 | YDR150W | NUM1 | hom | Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex |
| 0.102 | 2.94E-9 | YBR208C | DUR1,2 | hom | Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress |
| 0.097 | 1.86E-8 | YGR217W | CCH1 | hom | Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together |
| 0.096 | 2.83E-8 | YOL144W | NOP8 | het | Nucleolar protein required for 60S ribosomal subunit biogenesis |
| 0.095 | 3.13E-8 | YKL140W | TGL1 | hom | Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes |
| 0.095 | 3.28E-8 | YJR054W | KCH1 | hom | Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate |
| 0.095 | 3.76E-8 | YBR291C | CTP1 | hom | Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family |
| 0.095 | 3.88E-8 | YNL077W | APJ1 | hom | Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress |
| 0.093 | 6.15E-8 | YPR184W | GDB1 | hom | Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress |
| 0.093 | 7.43E-8 | YDR042C_p | YDR042C_p | hom | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant |
| 0.091 | 1.41E-7 | YOR231W | MKK1 | hom | MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication |