YNL176C_p / TDA7

Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL176C / TDA7

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:6.13|P-value:2.86E-10 ID:SGTC_95|Compound:0471-0001|FD-Score:3.68|P-value:1.02E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.95|P-value:2.96E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.07|P-value:8.93E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.19|P-value:5.95E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:5.39|P-value:2.59E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:3.12|P-value:8.24E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.11|P-value:7.93E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.13|P-value:7.42E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.29|P-value:4.44E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.05|P-value:9.72E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.17|P-value:6.77E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.14|P-value:1.45E-5 ID:SGTC_1675|Compound:st018485|FD-Score:4.23|P-value:9.43E-6 ID:SGTC_1783|Compound:st039459|FD-Score:5.14|P-value:1.04E-7 ID:SGTC_2019|Compound:4016004|FD-Score:-3.19|P-value:5.92E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.57|P-value:1.92E-6 ID:SGTC_2024|Compound:5144227|FD-Score:-4.00|P-value:2.37E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.99|P-value:2.72E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.63|P-value:1.22E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.79|P-value:6.44E-7 ID:SGTC_2836|Compound:9010338|FD-Score:5.93|P-value:9.82E-10 ID:SGTC_2862|Compound:9027634|FD-Score:-3.26|P-value:4.53E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.73|P-value:8.23E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.84|P-value:4.78E-5 ID:SGTC_2904|Compound:7225135|FD-Score:8.15|P-value:8.38E-17 ID:SGTC_2905|Compound:7799065|FD-Score:5.22|P-value:6.52E-8 ID:SGTC_2909|Compound:7941780|FD-Score:4.26|P-value:8.49E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.14|P-value:7.71E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.59|P-value:1.46E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.97|P-value:2.70E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.84|P-value:5.07E-7 ID:SGTC_3009|Compound:9080819|FD-Score:3.20|P-value:6.14E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.17|P-value:6.91E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:6.13|P-value:2.86E-10 ID:SGTC_95|Compound:0471-0001|FD-Score:3.68|P-value:1.02E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.95|P-value:2.96E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.07|P-value:8.93E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.19|P-value:5.95E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:5.39|P-value:2.59E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:3.12|P-value:8.24E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.11|P-value:7.93E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.13|P-value:7.42E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.29|P-value:4.44E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.05|P-value:9.72E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.17|P-value:6.77E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.14|P-value:1.45E-5 ID:SGTC_1675|Compound:st018485|FD-Score:4.23|P-value:9.43E-6 ID:SGTC_1783|Compound:st039459|FD-Score:5.14|P-value:1.04E-7 ID:SGTC_2019|Compound:4016004|FD-Score:-3.19|P-value:5.92E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.57|P-value:1.92E-6 ID:SGTC_2024|Compound:5144227|FD-Score:-4.00|P-value:2.37E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.99|P-value:2.72E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.63|P-value:1.22E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.79|P-value:6.44E-7 ID:SGTC_2836|Compound:9010338|FD-Score:5.93|P-value:9.82E-10 ID:SGTC_2862|Compound:9027634|FD-Score:-3.26|P-value:4.53E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.73|P-value:8.23E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.84|P-value:4.78E-5 ID:SGTC_2904|Compound:7225135|FD-Score:8.15|P-value:8.38E-17 ID:SGTC_2905|Compound:7799065|FD-Score:5.22|P-value:6.52E-8 ID:SGTC_2909|Compound:7941780|FD-Score:4.26|P-value:8.49E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.14|P-value:7.71E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.59|P-value:1.46E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.97|P-value:2.70E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.84|P-value:5.07E-7 ID:SGTC_3009|Compound:9080819|FD-Score:3.20|P-value:6.14E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.17|P-value:6.91E-4

Top fitness defect scores for YNL176C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2904 7225135 8.15 42.0 µM 8.38E-17 1 1.85E-16
2 SGTC_6 0844-0013 6.13 19.8 µM 2.86E-10 13 4.42E-10
3 SGTC_2836 9010338 5.93 19.5 µM 9.82E-10 RPP1 & pyrimidine depletion 5 1.48E-9
4 SGTC_880 0833-0487 5.39 87.2 µM 2.59E-8 mitochondrial processes 3 3.61E-8
5 SGTC_2905 7799065 5.22 20.1 µM 6.52E-8 3 8.90E-8
6 SGTC_1783 st039459 5.14 87.5 µM 1.04E-7 Golgi 10 1.40E-7
7 SGTC_3000 9075062 4.84 71.4 µM 5.07E-7 5 6.59E-7
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.79 3.7 µM 6.44E-7 35 8.34E-7
9 SGTC_2023 5144124 4.57 124.0 µM 1.92E-6 15 2.43E-6
10 SGTC_2909 7941780 4.26 10.5 µM 8.49E-6 17 1.04E-5
11 SGTC_1675 st018485 4.23 24.5 µM 9.43E-6 60S ribosome export 19 1.15E-5
12 SGTC_1617 st002906 4.14 78.0 µM 1.45E-5 24 1.75E-5
13 SGTC_2058 5236698 3.99 133.0 µM 2.72E-5 27 3.24E-5
14 SGTC_2865 9030313 3.73 52.0 µM 8.23E-5 18 9.56E-5
15 SGTC_95 0471-0001 3.68 561.1 µM 1.02E-4 31 1.18E-4
16 SGTC_2104 5389443 3.63 200.0 µM 1.22E-4 21 1.40E-4
17 SGTC_2971 9092186 3.59 9.9 µM 1.46E-4 ergosterol biosynthesis 43 1.67E-4
18 SGTC_1420 4'-methoxyflavone 3.29 42.0 µM 4.44E-4 30 4.97E-4
19 SGTC_3009 9080819 3.20 71.4 µM 6.14E-4 41 6.84E-4
20 SGTC_1603 st002045 3.17 67.8 µM 6.77E-4 TSC3-RPN4 41 7.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 2.85E-38 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.194 1.08E-29 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.182 2.62E-26 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.175 1.30E-24 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.174 3.16E-24 YML067C ERV41 hom Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
0.168 1.34E-22 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.164 1.45E-21 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.160 9.30E-21 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.157 7.50E-20 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.155 1.30E-19 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.154 3.50E-19 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.153 3.90E-19 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.152 6.75E-19 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.150 2.73E-18 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.149 4.12E-18 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1