YNL178W / RPS3

Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL178W / RPS3

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:4.65|P-value:6.64E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.85|P-value:7.88E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.49|P-value:1.00E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.47|P-value:3.35E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.43|P-value:1.20E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-5.50|P-value:2.60E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:5.13|P-value:1.23E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.82|P-value:3.72E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.06|P-value:3.05E-7 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.96|P-value:5.10E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.74|P-value:4.80E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:6.34|P-value:8.93E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.87|P-value:6.60E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.01|P-value:4.87E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.73|P-value:9.95E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:6.77|P-value:1.26E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.39|P-value:1.56E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-8.35|P-value:2.55E-12 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.68|P-value:5.29E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.32|P-value:1.91E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.02|P-value:4.77E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-6.48|P-value:4.16E-8 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.28|P-value:1.93E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-5.52|P-value:2.48E-6 ID:SGTC_1771|Compound:st048882|FD-Score:3.87|P-value:7.50E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.93|P-value:2.23E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-5.22|P-value:7.69E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-5.31|P-value:5.42E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-5.18|P-value:8.81E-6 ID:SGTC_1942|Compound:st076330|FD-Score:5.58|P-value:2.19E-6 ID:SGTC_1954|Compound:st077032|FD-Score:4.20|P-value:2.82E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.00|P-value:5.09E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-4.01|P-value:4.50E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.24|P-value:2.19E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.28|P-value:1.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-6.76|P-value:1.12E-8 ID:SGTC_2399|Compound:5884133|FD-Score:7.24|P-value:1.29E-9 ID:SGTC_2404|Compound:5161160|FD-Score:-9.65|P-value:7.31E-16 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.69|P-value:5.76E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.53|P-value:2.73E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.28|P-value:6.23E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.70|P-value:5.62E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.54|P-value:8.52E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.31|P-value:1.96E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:5.25|P-value:7.93E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.40|P-value:3.91E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.83|P-value:7.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.96|P-value:5.69E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.02|P-value:4.85E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.62|P-value:1.87E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-4.53|P-value:8.62E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.81|P-value:8.80E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-4.37|P-value:1.47E-4 ID:SGTC_3207|Compound:9114163|FD-Score:6.24|P-value:1.43E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-5.06|P-value:1.37E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.91|P-value:6.65E-4 ID:SGTC_3235|Compound:9132602|FD-Score:6.57|P-value:3.16E-8 ID:SGTC_3249|Compound:9135183|FD-Score:-4.62|P-value:6.47E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-4.85|P-value:2.99E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.67|P-value:5.51E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-3.75|P-value:9.30E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.65|P-value:6.64E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.85|P-value:7.88E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.49|P-value:1.00E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.47|P-value:3.35E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.43|P-value:1.20E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-5.50|P-value:2.60E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:5.13|P-value:1.23E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.82|P-value:3.72E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:6.06|P-value:3.05E-7 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.96|P-value:5.10E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.74|P-value:4.80E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:6.34|P-value:8.93E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.87|P-value:6.60E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.01|P-value:4.87E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.73|P-value:9.95E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:6.77|P-value:1.26E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.39|P-value:1.56E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-8.35|P-value:2.55E-12 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.68|P-value:5.29E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.32|P-value:1.91E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.02|P-value:4.77E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-6.48|P-value:4.16E-8 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.28|P-value:1.93E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-5.52|P-value:2.48E-6 ID:SGTC_1771|Compound:st048882|FD-Score:3.87|P-value:7.50E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.93|P-value:2.23E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-5.22|P-value:7.69E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-5.31|P-value:5.42E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-5.18|P-value:8.81E-6 ID:SGTC_1942|Compound:st076330|FD-Score:5.58|P-value:2.19E-6 ID:SGTC_1954|Compound:st077032|FD-Score:4.20|P-value:2.82E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.00|P-value:5.09E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-4.01|P-value:4.50E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.24|P-value:2.19E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-4.28|P-value:1.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-6.76|P-value:1.12E-8 ID:SGTC_2399|Compound:5884133|FD-Score:7.24|P-value:1.29E-9 ID:SGTC_2404|Compound:5161160|FD-Score:-9.65|P-value:7.31E-16 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.69|P-value:5.76E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.53|P-value:2.73E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.28|P-value:6.23E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.70|P-value:5.62E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.54|P-value:8.52E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.31|P-value:1.96E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:5.25|P-value:7.93E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.40|P-value:3.91E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.83|P-value:7.40E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.96|P-value:5.69E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.02|P-value:4.85E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.62|P-value:1.87E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-4.53|P-value:8.62E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.81|P-value:8.80E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-4.37|P-value:1.47E-4 ID:SGTC_3207|Compound:9114163|FD-Score:6.24|P-value:1.43E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-5.06|P-value:1.37E-5 ID:SGTC_3234|Compound:9132280|FD-Score:3.91|P-value:6.65E-4 ID:SGTC_3235|Compound:9132602|FD-Score:6.57|P-value:3.16E-8 ID:SGTC_3249|Compound:9135183|FD-Score:-4.62|P-value:6.47E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-4.85|P-value:2.99E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.67|P-value:5.51E-5 ID:SGTC_3316|Compound:9136639|FD-Score:-3.75|P-value:9.30E-4

Top fitness defect scores for YNL178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2399 5884133 7.24 200.0 µM 1.29E-9 cell wall signaling 3 2.31E-13 0.75
2 SGTC_1190 1486-1332 6.77 13.0 µM 1.26E-8 1 6.44E-12 1.68
3 SGTC_3235 9132602 6.57 49.5 µM 3.16E-8 1 2.46E-11 2.32
4 SGTC_975 1335-0046 6.34 28.5 µM 8.93E-8 RPP1 & pyrimidine depletion 2 1.12E-10 1.42
5 SGTC_3207 9114163 6.24 49.5 µM 1.43E-7 1 2.22E-10 0.78
6 SGTC_800 3448-7362 6.06 155.0 µM 3.05E-7 translation 22 6.72E-10 0.17
7 SGTC_2963 9082507 5.62 9.0 µM 1.87E-6 2 9.37E-9 0.45
8 SGTC_1942 st076330 5.58 65.2 µM 2.19E-6 1 1.18E-8 0.70
9 SGTC_2581 avocatin a 5.53 64.0 µM 2.73E-6 sphingolipid biosynthesis & PDR1 1 1.63E-8 1.01
10 SGTC_576 1073-0113 5.47 22.7 µM 3.35E-6 redox potentiating 18 2.19E-8 0.10
11 SGTC_2730 imipramine 5.25 71.3 µM 7.93E-6 3 7.67E-8 0.79
12 SGTC_625 k213-0058 5.13 121.0 µM 1.23E-5 translation 6 1.46E-7 0.00
13 SGTC_708 3448-5400 4.82 146.0 µM 3.72E-5 10 7.22E-7 0.16
14 SGTC_974 1326-0144 4.74 138.0 µM 4.80E-5 ERG2 5 1.04E-6 0.45
15 SGTC_2658 polymyxin b sulfate 4.70 77.0 µM 5.62E-5 NEO1 9 1.31E-6 0.18
16 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.69 92.6 µM 5.76E-5 7 1.36E-6 0.21
17 SGTC_114 0364-0001 4.65 490.3 µM 6.64E-5 1 1.67E-6 0.47
18 SGTC_1201 1889-3372 4.39 45.9 µM 1.56E-4 Golgi 6 5.73E-6 0.39
19 SGTC_1363 1636-0063 4.32 10.4 µM 1.91E-4 Golgi 5 7.74E-6 0.14
20 SGTC_2729 fluphenazine 4.31 10.7 µM 1.96E-4 5 8.04E-6 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.306 1.39E-73 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.305 2.52E-73 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.282 3.41E-62 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.239 6.43E-45 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.197 1.33E-30 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.181 3.90E-26 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.177 5.99E-25 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.177 6.27E-25 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.174 4.55E-24 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.168 1.39E-22 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.166 4.87E-22 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.159 1.80E-20 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.159 1.88E-20 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.157 5.20E-20 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.154 3.47E-19 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA