YNL179C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL179C / YNL179C

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.80|P-value:7.27E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.37|P-value:3.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.94|P-value:1.93E-19 ID:SGTC_103|Compound:0844-0104|FD-Score:9.81|P-value:5.06E-23 ID:SGTC_278|Compound:4092-0821|FD-Score:3.12|P-value:9.06E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.40|P-value:3.32E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.61|P-value:1.56E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.10|P-value:9.66E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.15|P-value:8.27E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.94|P-value:4.11E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.76|P-value:8.36E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.05|P-value:2.61E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.35|P-value:4.00E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.06|P-value:2.45E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.17|P-value:7.64E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.93|P-value:4.33E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.78|P-value:9.03E-7 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.93|P-value:4.23E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.87|P-value:5.48E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.19|P-value:7.29E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.54|P-value:2.88E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.14|P-value:8.46E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.78|P-value:7.93E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.21|P-value:2.64E-10 ID:SGTC_2326|Compound:6164455|FD-Score:-3.73|P-value:9.55E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.24|P-value:6.15E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.25|P-value:5.86E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.90|P-value:4.74E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.59|P-value:1.69E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.11|P-value:2.00E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.40|P-value:3.42E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.49|P-value:2.45E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.52|P-value:3.06E-6 ID:SGTC_3050|Compound:9093513|FD-Score:4.81|P-value:7.60E-7 ID:SGTC_3163|Compound:9099914|FD-Score:3.17|P-value:7.73E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.80|P-value:7.27E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.37|P-value:3.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.94|P-value:1.93E-19 ID:SGTC_103|Compound:0844-0104|FD-Score:9.81|P-value:5.06E-23 ID:SGTC_278|Compound:4092-0821|FD-Score:3.12|P-value:9.06E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.40|P-value:3.32E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.61|P-value:1.56E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.10|P-value:9.66E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.15|P-value:8.27E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.94|P-value:4.11E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.76|P-value:8.36E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:4.05|P-value:2.61E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.35|P-value:4.00E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.06|P-value:2.45E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.17|P-value:7.64E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.93|P-value:4.33E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.78|P-value:9.03E-7 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.93|P-value:4.23E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.87|P-value:5.48E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.19|P-value:7.29E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.54|P-value:2.88E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.14|P-value:8.46E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.78|P-value:7.93E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.21|P-value:2.64E-10 ID:SGTC_2326|Compound:6164455|FD-Score:-3.73|P-value:9.55E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.24|P-value:6.15E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.25|P-value:5.86E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.90|P-value:4.74E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.59|P-value:1.69E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.11|P-value:2.00E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.40|P-value:3.42E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.49|P-value:2.45E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.52|P-value:3.06E-6 ID:SGTC_3050|Compound:9093513|FD-Score:4.81|P-value:7.60E-7 ID:SGTC_3163|Compound:9099914|FD-Score:3.17|P-value:7.73E-4

Top fitness defect scores for YNL179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 9.81 51.8 µM 5.06E-23 ERAD & cell cycle 31 4.86E-23
2 SGTC_58 0957-0393 8.94 9.0 µM 1.93E-19 cell wall 100 1.87E-19
3 SGTC_2322 7413319 6.21 38.2 µM 2.64E-10 ERAD & cell cycle 61 2.60E-10
4 SGTC_2696 st077691 4.90 74.3 µM 4.74E-7 16 4.71E-7
5 SGTC_3050 9093513 4.81 49.5 µM 7.60E-7 7 7.55E-7
6 SGTC_1506 4226-2149 4.78 212.0 µM 9.03E-7 16 8.98E-7
7 SGTC_1729 st035615 4.54 46.0 µM 2.88E-6 21 2.86E-6
8 SGTC_2999 9069765 4.52 71.4 µM 3.06E-6 amide catabolism 13 3.05E-6
9 SGTC_2841 9004761 4.11 39.0 µM 2.00E-5 amide catabolism 23 2.00E-5
10 SGTC_1136 pergolide 4.06 1.1 µM 2.45E-5 34 2.45E-5
11 SGTC_887 0885-0007 4.05 9.6 µM 2.61E-5 endomembrane recycling 33 2.60E-5
12 SGTC_830 4076-0286 3.94 57.8 µM 4.11E-5 translation 59 4.10E-5
13 SGTC_1535 tetrahydropapaveroline hydrobromide 3.93 54.3 µM 4.23E-5 RPP1 & pyrimidine depletion 12 4.22E-5
14 SGTC_1335 1486-0900 3.93 202.0 µM 4.33E-5 26 4.32E-5
15 SGTC_1564 D-Arginine 3.87 115.0 µM 5.48E-5 29 5.47E-5
16 SGTC_1 0258-0098 3.80 57.4 µM 7.27E-5 heme biosynthesis & mitochondrial translocase 9 7.25E-5
17 SGTC_1993 st073995 3.78 70.8 µM 7.93E-5 25 7.91E-5
18 SGTC_855 0428-0020 3.76 25.0 µM 8.36E-5 Golgi 25 8.35E-5
19 SGTC_2697 mebhydrolin 3.72 72.4 µM 1.01E-4 NEO1 74 1.01E-4
20 SGTC_518 1021-0119 3.61 62.6 µM 1.56E-4 ERG2 63 1.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.250 6.16E-49 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.229 5.24E-41 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.228 5.89E-41 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.215 1.65E-36 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.213 6.93E-36 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.207 5.67E-34 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.207 7.06E-34 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.206 1.46E-33 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.203 2.03E-32 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.202 2.34E-32 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.196 1.70E-30 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.196 2.31E-30 YCR049C_d YCR049C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.193 1.21E-29 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.192 2.80E-29 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.191 8.61E-29 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids