YNL180C / RHO5

Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL180C / RHO5

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.50|P-value:5.61E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.99|P-value:7.76E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.40|P-value:6.31E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.85|P-value:1.72E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.38|P-value:1.81E-7 ID:SGTC_950|Compound:1165-0508|FD-Score:4.22|P-value:3.20E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.49|P-value:1.05E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:2.27E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.52|P-value:4.24E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.43|P-value:7.12E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.10|P-value:5.07E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.86|P-value:1.62E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.39|P-value:8.20E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.41|P-value:6.13E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.32|P-value:8.08E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.43|P-value:5.57E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-5.21|P-value:5.72E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-4.50|P-value:1.34E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-3.84|P-value:1.77E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.38|P-value:8.43E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.46|P-value:6.50E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.71|P-value:2.82E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.35|P-value:7.27E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.52|P-value:9.50E-6 ID:SGTC_2942|Compound:9052777|FD-Score:3.84|P-value:1.36E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.53|P-value:5.14E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.49|P-value:4.68E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.22|P-value:3.20E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.56|P-value:7.86E-6 ID:SGTC_3349|Compound:9149703|FD-Score:3.35|P-value:7.29E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.50|P-value:5.61E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.99|P-value:7.76E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.40|P-value:6.31E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.85|P-value:1.72E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.38|P-value:1.81E-7 ID:SGTC_950|Compound:1165-0508|FD-Score:4.22|P-value:3.20E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.49|P-value:1.05E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:2.27E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.52|P-value:4.24E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.43|P-value:7.12E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.10|P-value:5.07E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.86|P-value:1.62E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.39|P-value:8.20E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.41|P-value:6.13E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.32|P-value:8.08E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.43|P-value:5.57E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-5.21|P-value:5.72E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-4.50|P-value:1.34E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-3.84|P-value:1.77E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.38|P-value:8.43E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.46|P-value:6.50E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.71|P-value:2.82E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.35|P-value:7.27E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.52|P-value:9.50E-6 ID:SGTC_2942|Compound:9052777|FD-Score:3.84|P-value:1.36E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.53|P-value:5.14E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.49|P-value:4.68E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.22|P-value:3.20E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.56|P-value:7.86E-6 ID:SGTC_3349|Compound:9149703|FD-Score:3.35|P-value:7.29E-4

Top fitness defect scores for YNL180C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1161 k007-0610 5.49 110.0 µM 1.05E-7 ERAD & cell cycle 67 2.02E-8
2 SGTC_733 4069-0007 5.38 56.1 µM 1.81E-7 ERAD & cell cycle 47 3.72E-8
3 SGTC_3193 9111931 4.56 49.5 µM 7.86E-6 11 2.55E-6
4 SGTC_2793 7325131 4.52 81.8 µM 9.50E-6 11 3.15E-6
5 SGTC_950 1165-0508 4.22 94.1 µM 3.20E-5 21 1.22E-5
6 SGTC_3191 9110352 4.22 49.5 µM 3.20E-5 6 1.22E-5
7 SGTC_1801 st050089 4.10 28.4 µM 5.07E-5 NEO1-PIK1 111 2.05E-5
8 SGTC_103 0844-0104 3.99 51.8 µM 7.76E-5 ERAD & cell cycle 142 3.30E-5
9 SGTC_2942 9052777 3.84 62.2 µM 1.36E-4 36 6.18E-5
10 SGTC_1541 2',3',6-trimethoxyflavone 3.52 64.0 µM 4.24E-4 24 2.19E-4
11 SGTC_3092 9117248 3.49 49.5 µM 4.68E-4 cell wall signaling 9 2.45E-4
12 SGTC_2011 4012611 3.43 177.0 µM 5.57E-4 mitochondrial processes 49 2.97E-4
13 SGTC_1929 genistein trimethyl ether 3.41 50.5 µM 6.13E-4 32 3.30E-4
14 SGTC_342 k048-0088 3.40 23.3 µM 6.31E-4 RSC & ERG11 34 3.41E-4
15 SGTC_2404 5161160 3.35 200.0 µM 7.27E-4 32 3.99E-4
16 SGTC_3349 9149703 3.35 23.0 µM 7.29E-4 28 4.01E-4
17 SGTC_1937 st074714 3.32 47.2 µM 8.08E-4 60 4.49E-4
18 SGTC_1291 0993-0025 3.23 5.8 µM 0.00106 28 6.10E-4
19 SGTC_1308 1187-1617 3.21 41.4 µM 0.00116 fatty acid desaturase (OLE1) 76 6.75E-4
20 SGTC_416 estradiol valerate 3.19 100.0 µM 0.00123 36 7.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.218 2.02E-37 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.207 1.13E-33 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.204 7.78E-33 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.182 2.03E-26 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.173 5.71E-24 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.173 6.91E-24 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.162 3.39E-21 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
0.160 1.18E-20 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.155 1.67E-19 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.149 4.47E-18 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.139 5.69E-16 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.139 8.17E-16 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.138 1.22E-15 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.130 4.22E-14 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.126 2.73E-13 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress