YNL181W_p

Putative oxidoreductase; required for cell viability

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL181W / YNL181W

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.43|P-value:1.80E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:2.92|P-value:2.18E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.80|P-value:3.79E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.18|P-value:2.35E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:4.83|P-value:2.93E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:2.63|P-value:7.76E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:2.65|P-value:7.22E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.43|P-value:1.68E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.04|P-value:1.26E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-2.77|P-value:4.00E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:2.67|P-value:6.66E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.97|P-value:1.07E-9 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.83|P-value:3.03E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:2.90|P-value:2.44E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.71|P-value:6.14E-9 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.26|P-value:4.24E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.76|P-value:2.70E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.78|P-value:2.65E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.37|P-value:2.48E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.92|P-value:1.18E-6 ID:SGTC_1783|Compound:st039459|FD-Score:6.23|P-value:2.90E-14 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.54|P-value:1.02E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.31|P-value:3.45E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.75|P-value:4.69E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.96|P-value:1.80E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.75|P-value:4.70E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.47|P-value:1.38E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-2.57|P-value:9.25E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.67|P-value:6.62E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.74|P-value:4.79E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-2.74|P-value:4.58E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:8.46|P-value:9.88E-25 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.06|P-value:1.13E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.49|P-value:3.09E-8 ID:SGTC_2814|Compound:7977482|FD-Score:2.89|P-value:2.50E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.61|P-value:8.47E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.89|P-value:2.38E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.12|P-value:8.78E-5 ID:SGTC_2891|Compound:9063876|FD-Score:2.73|P-value:5.20E-4 ID:SGTC_3105|Compound:9121040|FD-Score:2.68|P-value:6.23E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.42|P-value:1.74E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.43|P-value:1.80E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:2.92|P-value:2.18E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.80|P-value:3.79E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.18|P-value:2.35E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:4.83|P-value:2.93E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:2.63|P-value:7.76E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:2.65|P-value:7.22E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.43|P-value:1.68E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.04|P-value:1.26E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-2.77|P-value:4.00E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:2.67|P-value:6.66E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.97|P-value:1.07E-9 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.83|P-value:3.03E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:2.90|P-value:2.44E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.71|P-value:6.14E-9 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.26|P-value:4.24E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.76|P-value:2.70E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.78|P-value:2.65E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.37|P-value:2.48E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.92|P-value:1.18E-6 ID:SGTC_1783|Compound:st039459|FD-Score:6.23|P-value:2.90E-14 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.54|P-value:1.02E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.31|P-value:3.45E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.75|P-value:4.69E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.96|P-value:1.80E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.75|P-value:4.70E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.47|P-value:1.38E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-2.57|P-value:9.25E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.67|P-value:6.62E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.74|P-value:4.79E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-2.74|P-value:4.58E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:8.46|P-value:9.88E-25 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.06|P-value:1.13E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.49|P-value:3.09E-8 ID:SGTC_2814|Compound:7977482|FD-Score:2.89|P-value:2.50E-4 ID:SGTC_2831|Compound:7999036|FD-Score:2.61|P-value:8.47E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.89|P-value:2.38E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.12|P-value:8.78E-5 ID:SGTC_2891|Compound:9063876|FD-Score:2.73|P-value:5.20E-4 ID:SGTC_3105|Compound:9121040|FD-Score:2.68|P-value:6.23E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.42|P-value:1.74E-5

Top fitness defect scores for YNL181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2629 bisabolol 8.46 100.0 µM 9.88E-25 1 1.35E-17 1.34
2 SGTC_1783 st039459 6.23 87.5 µM 2.90E-14 Golgi 2 2.30E-10 0.91
3 SGTC_884 0851-0618 4.97 334.0 µM 1.07E-9 2 3.39E-7 0.66
4 SGTC_367 0335-0881 4.83 7.1 µM 2.93E-9 ubiquinone biosynthesis & proteasome 13 6.81E-7 0.10
5 SGTC_2764 methyldopa 4.49 94.7 µM 3.09E-8 1 3.51E-6 0.34
6 SGTC_360 0957-0399 4.18 1.0 µM 2.35E-7 cell wall 11 1.44E-5 0.14
7 SGTC_1379 2144-0755 3.92 36.5 µM 1.18E-6 5 4.45E-5 0.17
8 SGTC_1246 0422-0085 3.78 105.0 µM 2.65E-6 11 7.86E-5 0.18
9 SGTC_1787 fluconazole 3.54 80.0 µM 1.02E-5 iron homeostasis 14 2.01E-4 0.12
10 SGTC_55 0767-0285 3.43 6.6 µM 1.80E-5 11 3.00E-4 0.13
11 SGTC_1368 1852-0141 3.37 284.0 µM 2.48E-5 ERG2 8 3.76E-4 0.08
12 SGTC_1882 5615643 3.31 20.0 µM 3.45E-5 TRP & mitochondrial translation 9 4.74E-4 0.06
13 SGTC_1213 1315-0166 3.26 115.0 µM 4.24E-5 26 5.48E-4 0.05
14 SGTC_2884 9058502 3.12 52.0 µM 8.78E-5 9 9.15E-4 0.08
15 SGTC_2630 antimycin a 3.06 100.0 µM 1.13E-4 mitochondrial processes 18 0.00109 0.05
16 SGTC_642 0335-0876 3.04 158.0 µM 1.26E-4 ubiquinone biosynthesis & proteasome 21 0.00118 0.10
17 SGTC_1917 st066507 2.96 28.5 µM 1.80E-4 Golgi 25 0.00152 0.01
18 SGTC_192 3455-0609 2.92 60.9 µM 2.18E-4 15 0.00174 0.02
19 SGTC_1191 1487-1166 2.90 10.6 µM 2.44E-4 azole & statin 12 0.00188 0.01
20 SGTC_2814 7977482 2.89 43.0 µM 2.50E-4 26 0.00191 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.77E-20 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.143 8.85E-17 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.129 5.39E-14 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.129 8.00E-14 YMR178W YMR178W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress
0.126 2.47E-13 YHL028W WSC4 hom ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
0.121 1.90E-12 YLR164W SHH4 hom Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.112 6.99E-11 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.110 1.69E-10 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.106 6.71E-10 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.106 7.01E-10 YIR028W DAL4 hom Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.102 3.25E-9 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.101 4.91E-9 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.099 9.81E-9 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.098 1.24E-8 YJL138C TIF2 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication
0.097 1.86E-8 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin