YNL187W / SWT21

Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL187W / SWT21

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.91|P-value:2.85E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.99|P-value:1.97E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.44|P-value:2.39E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:3.06|P-value:8.22E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.63|P-value:9.33E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.52|P-value:1.62E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.30|P-value:4.88E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:4.25|P-value:6.16E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.26|P-value:3.97E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.51|P-value:1.77E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:4.35|P-value:3.81E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:6.05|P-value:2.35E-10 ID:SGTC_999|Compound:4022-0066|FD-Score:3.13|P-value:6.47E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.14|P-value:6.25E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.54|P-value:1.32E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.77|P-value:5.30E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.88|P-value:3.15E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.69|P-value:7.39E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.36|P-value:2.67E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.02|P-value:9.41E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.13|P-value:6.38E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.87|P-value:3.44E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:5.10|P-value:7.79E-8 ID:SGTC_1740|Compound:st038286|FD-Score:5.49|P-value:8.15E-9 ID:SGTC_1781|Compound:st038725|FD-Score:-3.52|P-value:1.44E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.95|P-value:2.35E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.82|P-value:4.30E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.67|P-value:7.95E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.50|P-value:1.57E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.41|P-value:2.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:4.07|P-value:1.39E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.20|P-value:4.87E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.70|P-value:6.92E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.51|P-value:1.52E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.02|P-value:9.16E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.19|P-value:5.21E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.27|P-value:3.79E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.39|P-value:2.36E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-9.12|P-value:2.90E-21 ID:SGTC_2992|Compound:9074591|FD-Score:-5.63|P-value:3.42E-9 ID:SGTC_2998|Compound:9066762|FD-Score:-3.43|P-value:2.06E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.26|P-value:3.92E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.31|P-value:3.23E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.08|P-value:7.57E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.91|P-value:2.85E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.99|P-value:1.97E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.52|P-value:1.41E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.44|P-value:2.39E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:3.06|P-value:8.22E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.61|P-value:1.02E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.63|P-value:9.33E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.52|P-value:1.62E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.30|P-value:4.88E-6 ID:SGTC_547|Compound:1120-0019|FD-Score:4.25|P-value:6.16E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:3.26|P-value:3.97E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.51|P-value:1.77E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:4.35|P-value:3.81E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:6.05|P-value:2.35E-10 ID:SGTC_999|Compound:4022-0066|FD-Score:3.13|P-value:6.47E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.14|P-value:6.25E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.54|P-value:1.32E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.77|P-value:5.30E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.88|P-value:3.15E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.69|P-value:7.39E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.36|P-value:2.67E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.02|P-value:9.41E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.13|P-value:6.38E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.87|P-value:3.44E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:5.10|P-value:7.79E-8 ID:SGTC_1740|Compound:st038286|FD-Score:5.49|P-value:8.15E-9 ID:SGTC_1781|Compound:st038725|FD-Score:-3.52|P-value:1.44E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.95|P-value:2.35E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.82|P-value:4.30E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.67|P-value:7.95E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.50|P-value:1.57E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.41|P-value:2.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:4.07|P-value:1.39E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.20|P-value:4.87E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.70|P-value:6.92E-5 ID:SGTC_2485|Compound:5633444|FD-Score:-3.51|P-value:1.52E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.02|P-value:9.16E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.19|P-value:5.21E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.27|P-value:3.79E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.39|P-value:2.36E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-9.12|P-value:2.90E-21 ID:SGTC_2992|Compound:9074591|FD-Score:-5.63|P-value:3.42E-9 ID:SGTC_2998|Compound:9066762|FD-Score:-3.43|P-value:2.06E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.26|P-value:3.92E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.31|P-value:3.23E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.08|P-value:7.57E-4

Top fitness defect scores for YNL187W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_997 3996-0078 6.05 137.0 µM 2.35E-10 3 7.17E-10
2 SGTC_1740 st038286 5.49 13.2 µM 8.15E-9 6 2.05E-8
3 SGTC_1698 5-fluorocytosine 5.10 1.1 µM 7.79E-8 exosome 2 1.73E-7
4 SGTC_379 3970-0972 4.52 5.9 µM 1.62E-6 tubulin folding & SWR complex 23 3.05E-6
5 SGTC_609 0986-0026 4.51 86.3 µM 1.77E-6 calcium & mitochondrial duress 20 3.31E-6
6 SGTC_286 k060-0067 4.44 22.9 µM 2.39E-6 tubulin folding & SWR complex 18 4.41E-6
7 SGTC_965 1291-5240 4.35 308.0 µM 3.81E-6 22 6.85E-6
8 SGTC_387 norethindrone acetate 4.30 66.7 µM 4.88E-6 7 8.66E-6
9 SGTC_547 1120-0019 4.25 610.0 nM 6.16E-6 azole & statin 24 1.08E-5
10 SGTC_2357 9067248 4.07 200.0 µM 1.39E-5 14 2.34E-5
11 SGTC_64 000l-0018 3.99 272.1 µM 1.97E-5 ubiquinone biosynthesis & proteasome 148 3.24E-5
12 SGTC_1882 5615643 3.95 20.0 µM 2.35E-5 TRP & mitochondrial translation 27 3.83E-5
13 SGTC_1913 st060213 3.95 96.1 µM 2.38E-5 30 3.88E-5
14 SGTC_25 0118-0223 3.91 35.7 µM 2.85E-5 17 4.60E-5
15 SGTC_1686 st019653 3.87 115.5 µM 3.44E-5 mitochondrial processes 12 5.49E-5
16 SGTC_1924 st058459 3.82 75.1 µM 4.30E-5 13 6.79E-5
17 SGTC_1343 1487-0095 3.77 224.0 µM 5.30E-5 9 8.27E-5
18 SGTC_1421 4029-0249 3.69 71.4 µM 7.39E-5 22 1.13E-4
19 SGTC_1941 st076221 3.67 61.8 µM 7.95E-5 sphingolipid biosynthesis & PDR1 92 1.21E-4
20 SGTC_349 k015-0014 3.63 24.0 µM 9.33E-5 30 1.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 8.60E-25 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.139 5.34E-16 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.130 4.00E-14 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.116 1.88E-11 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.114 3.45E-11 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.112 7.26E-11 YJL137C GLG2 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.095 3.87E-8 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.095 4.03E-8 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.093 6.79E-8 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.092 1.05E-7 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.091 1.22E-7 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.091 1.45E-7 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
0.083 1.30E-6 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.083 1.33E-6 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.080 3.63E-6 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle