YNL190W_p

Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL190W / YNL190W

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:4.11|P-value:3.51E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.00|P-value:4.29E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:4.22|P-value:2.15E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.92|P-value:7.31E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.37|P-value:5.52E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.27|P-value:7.98E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.67|P-value:1.90E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.13|P-value:3.19E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.16|P-value:9.34E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.43|P-value:4.60E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.12|P-value:3.38E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:5.01|P-value:5.87E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:5.67|P-value:1.93E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:8.30|P-value:3.78E-16 ID:SGTC_935|Compound:2996-0153|FD-Score:3.25|P-value:8.37E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:6.19|P-value:9.46E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.53|P-value:3.22E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.45|P-value:4.25E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1674|Compound:st016616|FD-Score:5.36|P-value:1.01E-7 ID:SGTC_1675|Compound:st018485|FD-Score:3.65|P-value:2.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.06|P-value:4.57E-7 ID:SGTC_1708|Compound:st033234|FD-Score:4.13|P-value:3.22E-5 ID:SGTC_1721|Compound:st082152|FD-Score:5.05|P-value:4.85E-7 ID:SGTC_1748|Compound:st037455|FD-Score:3.22|P-value:9.28E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.48|P-value:3.79E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.57|P-value:4.70E-6 ID:SGTC_1798|Compound:st045719|FD-Score:4.96|P-value:7.53E-7 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.10|P-value:2.63E-12 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.25|P-value:8.53E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.20|P-value:9.87E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.47|P-value:3.99E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:9.33|P-value:5.88E-20 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.59|P-value:4.43E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.27|P-value:8.53E-13 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:7.61|P-value:7.26E-14 ID:SGTC_2815|Compound:7968870|FD-Score:3.46|P-value:4.08E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.88|P-value:8.52E-5 ID:SGTC_2862|Compound:9027634|FD-Score:4.58|P-value:4.56E-6 ID:SGTC_2968|Compound:9090663|FD-Score:4.11|P-value:3.47E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.22|P-value:9.34E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_3232|Compound:9132874|FD-Score:5.35|P-value:1.05E-7 ID:SGTC_3245|Compound:9134821|FD-Score:-3.48|P-value:3.11E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:4.11|P-value:3.51E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.00|P-value:4.29E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:4.22|P-value:2.15E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.92|P-value:7.31E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.37|P-value:5.52E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.27|P-value:7.98E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.67|P-value:1.90E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.13|P-value:3.19E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.16|P-value:9.34E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.43|P-value:4.60E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.12|P-value:3.38E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:5.01|P-value:5.87E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:5.67|P-value:1.93E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:8.30|P-value:3.78E-16 ID:SGTC_935|Compound:2996-0153|FD-Score:3.25|P-value:8.37E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:6.19|P-value:9.46E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.53|P-value:3.22E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.45|P-value:4.25E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1674|Compound:st016616|FD-Score:5.36|P-value:1.01E-7 ID:SGTC_1675|Compound:st018485|FD-Score:3.65|P-value:2.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.06|P-value:4.57E-7 ID:SGTC_1708|Compound:st033234|FD-Score:4.13|P-value:3.22E-5 ID:SGTC_1721|Compound:st082152|FD-Score:5.05|P-value:4.85E-7 ID:SGTC_1748|Compound:st037455|FD-Score:3.22|P-value:9.28E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.48|P-value:3.79E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.57|P-value:4.70E-6 ID:SGTC_1798|Compound:st045719|FD-Score:4.96|P-value:7.53E-7 ID:SGTC_1873|Compound:rapamycin|FD-Score:7.10|P-value:2.63E-12 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.25|P-value:8.53E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.20|P-value:9.87E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.47|P-value:3.99E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:9.33|P-value:5.88E-20 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.59|P-value:4.43E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.27|P-value:8.53E-13 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:7.61|P-value:7.26E-14 ID:SGTC_2815|Compound:7968870|FD-Score:3.46|P-value:4.08E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.88|P-value:8.52E-5 ID:SGTC_2862|Compound:9027634|FD-Score:4.58|P-value:4.56E-6 ID:SGTC_2968|Compound:9090663|FD-Score:4.11|P-value:3.47E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.22|P-value:9.34E-4 ID:SGTC_3169|Compound:9102970|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_3232|Compound:9132874|FD-Score:5.35|P-value:1.05E-7 ID:SGTC_3245|Compound:9134821|FD-Score:-3.48|P-value:3.11E-4

Top fitness defect scores for YNL190W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2496 diffractaic acid 9.33 79.8 µM 5.88E-20 1 5.19E-21
2 SGTC_923 1900-2434 8.30 73.3 µM 3.78E-16 RNA processing & uracil transport 5 5.38E-17
3 SGTC_2589 lobaric acid 7.61 100.0 µM 7.26E-14 4 1.38E-14
4 SGTC_2581 avocatin a 7.27 64.0 µM 8.53E-13 sphingolipid biosynthesis & PDR1 8 1.85E-13
5 SGTC_1873 rapamycin 7.10 2.0 nM 2.63E-12 18 6.09E-13
6 SGTC_1021 4476-0760 6.19 85.3 µM 9.46E-10 4 3.02E-10
7 SGTC_922 1866-0035 5.67 480.0 µM 1.93E-8 excess fatty acid 22 7.30E-9
8 SGTC_1674 st016616 5.36 23.6 µM 1.01E-7 5 4.16E-8
9 SGTC_3232 9132874 5.35 49.5 µM 1.05E-7 RPP1 & pyrimidine depletion 3 4.34E-8
10 SGTC_1687 st020778 5.06 55.4 µM 4.57E-7 130 2.06E-7
11 SGTC_1721 st082152 5.05 9.3 µM 4.85E-7 60S ribosome export 9 2.19E-7
12 SGTC_804 1595-0054 5.01 20.9 µM 5.87E-7 sphingolipid biosynthesis & PDR1 19 2.68E-7
13 SGTC_1798 st045719 4.96 61.0 µM 7.53E-7 4 3.49E-7
14 SGTC_2503 beta-caryophyllene alcohol 4.59 24.7 µM 4.43E-6 5 2.26E-6
15 SGTC_2862 9027634 4.58 71.4 µM 4.56E-6 ERG2 21 2.33E-6
16 SGTC_1772 st048439 4.57 82.2 µM 4.70E-6 23 2.41E-6
17 SGTC_130 0136-0219 4.22 337.7 µM 2.15E-5 16 1.20E-5
18 SGTC_299 1273-0059 4.13 1.4 µM 3.19E-5 25 1.82E-5
19 SGTC_1708 st033234 4.13 31.8 µM 3.22E-5 11 1.84E-5
20 SGTC_632 0781-2353 4.12 4.7 µM 3.38E-5 Golgi 39 1.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.41E-13 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.116 1.99E-11 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.110 1.68E-10 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.108 3.36E-10 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.107 4.91E-10 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.106 6.43E-10 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.106 7.96E-10 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.09E-9 YDR156W RPA14 hom RNA polymerase I subunit A14
0.105 1.26E-9 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.104 1.45E-9 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.104 1.65E-9 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.103 2.28E-9 YGR269W_d YGR269W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
0.101 5.42E-9 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.101 5.51E-9 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.100 6.09E-9 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p