YNL193W_p

Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL193W / YNL193W

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:4.47|P-value:1.59E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.62|P-value:7.68E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.38|P-value:3.03E-4 ID:SGTC_442|Compound:cape|FD-Score:2.99|P-value:8.50E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.87|P-value:2.67E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.03|P-value:7.35E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.51|P-value:1.20E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.36|P-value:2.21E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.16|P-value:6.87E-6 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.28|P-value:2.98E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.65|P-value:6.67E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.24|P-value:5.15E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.50|P-value:1.26E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.12|P-value:5.37E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.74|P-value:4.64E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.45|P-value:1.51E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.33|P-value:2.43E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.40|P-value:2.21E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.21|P-value:3.77E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.18|P-value:3.51E-8 ID:SGTC_1917|Compound:st066507|FD-Score:5.53|P-value:4.27E-9 ID:SGTC_1972|Compound:st070201|FD-Score:-3.15|P-value:7.06E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.00|P-value:8.32E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.58|P-value:8.97E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.37|P-value:2.05E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.62|P-value:7.63E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.20|P-value:4.01E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.67|P-value:9.55E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.30|P-value:3.66E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.01|P-value:8.08E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.38|P-value:3.04E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.23|P-value:3.61E-4 ID:SGTC_2678|Compound:equilin|FD-Score:6.78|P-value:9.10E-13 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.96|P-value:9.31E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.05|P-value:6.91E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.94|P-value:3.29E-10 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.61|P-value:1.24E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.82|P-value:3.20E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.50|P-value:1.24E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.01|P-value:1.41E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-3.23|P-value:5.35E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.34|P-value:2.30E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.95|P-value:1.87E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-10.50|P-value:1.56E-27 ID:SGTC_3219|Compound:9131112|FD-Score:3.19|P-value:4.18E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.16|P-value:7.00E-6 ID:SGTC_3332|Compound:9141069|FD-Score:3.51|P-value:1.21E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:4.47|P-value:1.59E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.62|P-value:7.68E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.38|P-value:3.03E-4 ID:SGTC_442|Compound:cape|FD-Score:2.99|P-value:8.50E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.43|P-value:1.63E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.87|P-value:2.67E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.03|P-value:7.35E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.51|P-value:1.20E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.36|P-value:2.21E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.16|P-value:6.87E-6 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.47|P-value:1.43E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.28|P-value:2.98E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.65|P-value:6.67E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.24|P-value:5.15E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.50|P-value:1.26E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.12|P-value:5.37E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.74|P-value:4.64E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.45|P-value:1.51E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.33|P-value:2.43E-4 ID:SGTC_1748|Compound:st037455|FD-Score:4.40|P-value:2.21E-6 ID:SGTC_1812|Compound:st052057|FD-Score:3.21|P-value:3.77E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.18|P-value:3.51E-8 ID:SGTC_1917|Compound:st066507|FD-Score:5.53|P-value:4.27E-9 ID:SGTC_1972|Compound:st070201|FD-Score:-3.15|P-value:7.06E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.00|P-value:8.32E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.58|P-value:8.97E-7 ID:SGTC_2063|Compound:5246145|FD-Score:3.37|P-value:2.05E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.62|P-value:7.63E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.20|P-value:4.01E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.67|P-value:9.55E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.30|P-value:3.66E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.01|P-value:8.08E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.38|P-value:3.04E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.23|P-value:3.61E-4 ID:SGTC_2678|Compound:equilin|FD-Score:6.78|P-value:9.10E-13 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.96|P-value:9.31E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.05|P-value:6.91E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:5.94|P-value:3.29E-10 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.61|P-value:1.24E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.82|P-value:3.20E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.50|P-value:1.24E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.01|P-value:1.41E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-3.23|P-value:5.35E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.34|P-value:2.30E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.09|P-value:5.93E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.95|P-value:1.87E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-10.50|P-value:1.56E-27 ID:SGTC_3219|Compound:9131112|FD-Score:3.19|P-value:4.18E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.16|P-value:7.00E-6 ID:SGTC_3332|Compound:9141069|FD-Score:3.51|P-value:1.21E-4

Top fitness defect scores for YNL193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2678 equilin 6.78 100.0 µM 9.10E-13 3 5.88E-12
2 SGTC_2749 bexarotene 5.94 57.4 µM 3.29E-10 4 1.45E-9
3 SGTC_1917 st066507 5.53 28.5 µM 4.27E-9 Golgi 15 1.59E-8
4 SGTC_1909 st060837 5.18 51.5 µM 3.51E-8 26 1.14E-7
5 SGTC_2024 5144227 4.58 134.0 µM 8.97E-7 23 2.34E-6
6 SGTC_49 0717-0965 4.47 32.1 µM 1.59E-6 60S ribosome export 12 3.98E-6
7 SGTC_1748 st037455 4.40 53.6 µM 2.21E-6 18 5.42E-6
8 SGTC_2379 9035213 4.30 200.0 µM 3.66E-6 14 8.67E-6
9 SGTC_1366 1683-0113 4.16 21.9 µM 6.87E-6 8 1.56E-5
10 SGTC_3222 9128301 4.16 49.5 µM 7.00E-6 60S ribosome export 24 1.59E-5
11 SGTC_2825 7998094 4.01 58.4 µM 1.41E-5 fatty acid desaturase (OLE1) 28 3.04E-5
12 SGTC_3216 9129716 3.95 49.5 µM 1.87E-5 RPP1 & pyrimidine depletion 24 3.98E-5
13 SGTC_1115 galangin 3.87 695.7 nM 2.67E-5 RPP1 & pyrimidine depletion 16 5.54E-5
14 SGTC_2767 sibutramine 3.82 71.5 µM 3.20E-5 23 6.55E-5
15 SGTC_1637 st007924 3.74 17.4 µM 4.64E-5 28 9.27E-5
16 SGTC_1479 0549-0158 3.65 134.0 µM 6.67E-5 38 1.30E-4
17 SGTC_2081 5214970 3.62 32.3 µM 7.63E-5 31 1.47E-4
18 SGTC_291 4130-1278 3.62 35.5 µM 7.68E-5 Golgi 22 1.48E-4
19 SGTC_1129 3453-1384 3.51 223.0 µM 1.20E-4 57 2.24E-4
20 SGTC_3332 9141069 3.51 11.2 µM 1.21E-4 30 2.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.47E-14 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.128 1.10E-13 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.116 1.51E-11 YFR005C SAD1 het Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
0.116 1.69E-11 YGR059W SPR3 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
0.105 1.15E-9 YOR385W_p YOR385W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
0.103 2.18E-9 YNL022C_p YNL022C_p hom Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis
0.100 6.84E-9 YOR011W AUS1 hom Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
0.097 2.17E-8 YKL218C SRY1 hom 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
0.095 3.28E-8 YIL128W MET18 hom Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19
0.095 3.61E-8 YPR079W MRL1 hom Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.086 5.78E-7 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.085 8.81E-7 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.084 1.25E-6 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
0.082 2.17E-6 YCL057W PRD1 hom Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress
0.081 2.79E-6 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1