YNL194C

Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL194C / YNL194C

Click on Significant Values for Screen Details ID:SGTC_191|Compound:3914-0123|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.39|P-value:2.26E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.27|P-value:2.52E-8 ID:SGTC_318|Compound:1488-0629|FD-Score:3.10|P-value:6.59E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.39|P-value:2.23E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.66|P-value:8.20E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.63|P-value:8.67E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:4.28|P-value:4.64E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.49|P-value:1.48E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.10|P-value:6.71E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.07|P-value:7.38E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.12|P-value:6.23E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.01|P-value:9.23E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.20|P-value:6.89E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.23|P-value:4.46E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.82|P-value:4.11E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.04|P-value:1.47E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.44|P-value:1.98E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.15|P-value:5.46E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.72|P-value:6.32E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.73|P-value:4.91E-7 ID:SGTC_2436|Compound:5633522|FD-Score:3.24|P-value:4.00E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.14|P-value:9.08E-6 ID:SGTC_2470|Compound:5664817|FD-Score:4.04|P-value:1.44E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.01|P-value:9.90E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.16|P-value:8.43E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.44|P-value:1.84E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.80|P-value:4.50E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:3.31|P-value:3.09E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.39|P-value:2.26E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.27|P-value:2.52E-8 ID:SGTC_318|Compound:1488-0629|FD-Score:3.10|P-value:6.59E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.39|P-value:2.23E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.66|P-value:8.20E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.63|P-value:8.67E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:4.28|P-value:4.64E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.49|P-value:1.48E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.10|P-value:6.71E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.07|P-value:7.38E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.12|P-value:6.23E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.01|P-value:9.23E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.56|P-value:1.13E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.20|P-value:6.89E-6 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.23|P-value:4.46E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.82|P-value:4.11E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.04|P-value:1.47E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.44|P-value:1.98E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.15|P-value:5.46E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.72|P-value:6.32E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.73|P-value:4.91E-7 ID:SGTC_2436|Compound:5633522|FD-Score:3.24|P-value:4.00E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.14|P-value:9.08E-6 ID:SGTC_2470|Compound:5664817|FD-Score:4.04|P-value:1.44E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.01|P-value:9.90E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.16|P-value:8.43E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.44|P-value:1.84E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.80|P-value:4.50E-5

Top fitness defect scores for YNL194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_294 k038-0071 5.27 157.0 µM 2.52E-8 ubiquinone biosynthesis & proteasome 29 6.92E-8
2 SGTC_2322 7413319 4.73 38.2 µM 4.91E-7 ERAD & cell cycle 111 1.12E-6
3 SGTC_802 4112-3352 4.28 742.0 µM 4.64E-6 15 9.22E-6
4 SGTC_1514 1189-1591 4.20 158.0 µM 6.89E-6 29 1.34E-5
5 SGTC_3131 9127911 4.16 49.5 µM 8.43E-6 23 1.61E-5
6 SGTC_2460 5552655 4.14 174.2 µM 9.08E-6 amide catabolism 27 1.73E-5
7 SGTC_2470 5664817 4.04 21.7 µM 1.44E-5 8 2.67E-5
8 SGTC_2238 6671620 4.04 73.2 µM 1.47E-5 29 2.72E-5
9 SGTC_580 1123-0028 3.63 41.0 µM 8.67E-5 DNA damage response 50 1.44E-4
10 SGTC_1483 3453-0561 3.56 55.9 µM 1.13E-4 31 1.85E-4
11 SGTC_824 1304-0008 3.49 100.0 µM 1.48E-4 DNA damage response 52 2.37E-4
12 SGTC_3136 9095672 3.44 49.5 µM 1.84E-4 42 2.92E-4
13 SGTC_457 grayanotoxin iii 3.39 135.0 µM 2.23E-4 105 3.49E-4
14 SGTC_195 4234-0266 3.39 16.6 µM 2.26E-4 59 3.53E-4
15 SGTC_191 3914-0123 3.31 66.5 µM 3.09E-4 60S ribosome export 5 4.74E-4
16 SGTC_2157 5649910 3.25 96.4 µM 3.84E-4 45 5.82E-4
17 SGTC_2436 5633522 3.24 8.1 µM 4.00E-4 36 6.05E-4
18 SGTC_2307 7538926 3.15 6.3 µM 5.46E-4 77 8.11E-4
19 SGTC_1100 amiodarone 3.12 5.1 µM 6.23E-4 46 9.16E-4
20 SGTC_318 1488-0629 3.10 67.2 µM 6.59E-4 copper-dependent oxidative stress 52 9.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.51E-16 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.097 1.71E-8 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.090 2.10E-7 YBR187W_p GDT1_p hom Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
0.087 4.28E-7 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.086 6.32E-7 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.084 9.90E-7 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.083 1.58E-6 YDR099W BMH2 hom 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.082 1.84E-6 YOL091W SPO21 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.082 1.88E-6 YFR049W YMR31 hom Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
0.082 2.10E-6 YGR266W YGR266W hom Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
0.081 2.31E-6 YCL001W-A_p YCL001W-A_p hom Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.081 2.55E-6 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.080 3.39E-6 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.079 5.06E-6 YNL296W_d YNL296W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog
0.076 1.08E-5 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance