YNL195C_p

Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL195C / YNL195C

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:3.73|P-value:2.78E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.58|P-value:4.50E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.82|P-value:1.99E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.49|P-value:5.78E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.89|P-value:1.58E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:5.12|P-value:1.01E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.62|P-value:4.02E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.91|P-value:1.47E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.09|P-value:7.64E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.09|P-value:7.62E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.39|P-value:8.15E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.44|P-value:7.20E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.57|P-value:4.64E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.54|P-value:5.25E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.47|P-value:6.53E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.72|P-value:2.82E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.41|P-value:7.63E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.41|P-value:7.70E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.91|P-value:2.61E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.42|P-value:7.28E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.42|P-value:7.61E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.53|P-value:5.39E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.49|P-value:6.18E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.65|P-value:8.20E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.90|P-value:1.51E-4 ID:SGTC_1703|Compound:st026983|FD-Score:5.96|P-value:1.62E-8 ID:SGTC_1776|Compound:st049249|FD-Score:4.43|P-value:2.03E-5 ID:SGTC_2013|Compound:4024628|FD-Score:-4.01|P-value:9.69E-5 ID:SGTC_2019|Compound:4016004|FD-Score:4.68|P-value:7.20E-6 ID:SGTC_2031|Compound:5180455|FD-Score:5.38|P-value:3.07E-7 ID:SGTC_2074|Compound:5212007|FD-Score:4.21|P-value:4.75E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-4.38|P-value:2.31E-5 ID:SGTC_2155|Compound:5570423|FD-Score:4.63|P-value:8.80E-6 ID:SGTC_2240|Compound:6690706|FD-Score:4.71|P-value:6.37E-6 ID:SGTC_2244|Compound:6635614|FD-Score:-3.62|P-value:3.76E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.90|P-value:1.52E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:5.04|P-value:1.50E-6 ID:SGTC_2254|Compound:7938975|FD-Score:-5.20|P-value:6.81E-7 ID:SGTC_2256|Compound:7954252|FD-Score:3.68|P-value:3.20E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-4.28|P-value:3.48E-5 ID:SGTC_2461|Compound:5755302|FD-Score:4.28|P-value:3.64E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.86|P-value:1.73E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.29|P-value:3.52E-5 ID:SGTC_2480|Compound:5767542|FD-Score:5.53|P-value:1.45E-7 ID:SGTC_2486|Compound:5283202|FD-Score:3.95|P-value:1.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.66|P-value:3.43E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.51|P-value:5.69E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.44|P-value:1.95E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.01|P-value:9.55E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.78|P-value:4.67E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.44|P-value:7.26E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.67|P-value:3.24E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.35|P-value:9.69E-4 ID:SGTC_2919|Compound:7978188|FD-Score:5.16|P-value:8.69E-7 ID:SGTC_2975|Compound:9084847|FD-Score:3.40|P-value:8.27E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.18|P-value:5.36E-5 ID:SGTC_3017|Compound:9080681|FD-Score:5.29|P-value:4.63E-7 ID:SGTC_3084|Compound:9116877|FD-Score:-3.55|P-value:4.85E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.82|P-value:3.86E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.43|P-value:7.50E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-5.24|P-value:5.56E-7 ID:SGTC_3253|Compound:9135987|FD-Score:3.38|P-value:8.73E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.73|P-value:2.78E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.58|P-value:4.50E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.82|P-value:1.99E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.49|P-value:5.78E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.89|P-value:1.58E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:5.12|P-value:1.01E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.62|P-value:4.02E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.91|P-value:1.47E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.09|P-value:7.64E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.09|P-value:7.62E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.39|P-value:8.15E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.44|P-value:7.20E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.57|P-value:4.64E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.54|P-value:5.25E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.47|P-value:6.53E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.72|P-value:2.82E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.41|P-value:7.63E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.41|P-value:7.70E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.91|P-value:2.61E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.42|P-value:7.28E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.42|P-value:7.61E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.53|P-value:5.39E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.49|P-value:6.18E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.65|P-value:8.20E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.90|P-value:1.51E-4 ID:SGTC_1703|Compound:st026983|FD-Score:5.96|P-value:1.62E-8 ID:SGTC_1776|Compound:st049249|FD-Score:4.43|P-value:2.03E-5 ID:SGTC_2013|Compound:4024628|FD-Score:-4.01|P-value:9.69E-5 ID:SGTC_2019|Compound:4016004|FD-Score:4.68|P-value:7.20E-6 ID:SGTC_2031|Compound:5180455|FD-Score:5.38|P-value:3.07E-7 ID:SGTC_2074|Compound:5212007|FD-Score:4.21|P-value:4.75E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-4.38|P-value:2.31E-5 ID:SGTC_2155|Compound:5570423|FD-Score:4.63|P-value:8.80E-6 ID:SGTC_2240|Compound:6690706|FD-Score:4.71|P-value:6.37E-6 ID:SGTC_2244|Compound:6635614|FD-Score:-3.62|P-value:3.76E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.90|P-value:1.52E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:5.04|P-value:1.50E-6 ID:SGTC_2254|Compound:7938975|FD-Score:-5.20|P-value:6.81E-7 ID:SGTC_2256|Compound:7954252|FD-Score:3.68|P-value:3.20E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-4.28|P-value:3.48E-5 ID:SGTC_2461|Compound:5755302|FD-Score:4.28|P-value:3.64E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.86|P-value:1.73E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.29|P-value:3.52E-5 ID:SGTC_2480|Compound:5767542|FD-Score:5.53|P-value:1.45E-7 ID:SGTC_2486|Compound:5283202|FD-Score:3.95|P-value:1.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.66|P-value:3.43E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.51|P-value:5.69E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.44|P-value:1.95E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.01|P-value:9.55E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.78|P-value:4.67E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.44|P-value:7.26E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.67|P-value:3.24E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.35|P-value:9.69E-4 ID:SGTC_2919|Compound:7978188|FD-Score:5.16|P-value:8.69E-7 ID:SGTC_2975|Compound:9084847|FD-Score:3.40|P-value:8.27E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.41|P-value:7.85E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.18|P-value:5.36E-5 ID:SGTC_3017|Compound:9080681|FD-Score:5.29|P-value:4.63E-7 ID:SGTC_3084|Compound:9116877|FD-Score:-3.55|P-value:4.85E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.82|P-value:3.86E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.43|P-value:7.50E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-5.24|P-value:5.56E-7 ID:SGTC_3253|Compound:9135987|FD-Score:3.38|P-value:8.73E-4

Top fitness defect scores for YNL195C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1703 st026983 5.96 48.3 µM 1.62E-8 2 1.25E-9
2 SGTC_2480 5767542 5.53 37.2 µM 1.45E-7 3 1.57E-8
3 SGTC_2031 5180455 5.38 200.0 µM 3.07E-7 5 3.75E-8
4 SGTC_3017 9080681 5.29 49.5 µM 4.63E-7 5 6.03E-8
5 SGTC_2919 7978188 5.16 46.4 µM 8.69E-7 7 1.25E-7
6 SGTC_630 4356-0227 5.12 183.0 µM 1.01E-6 3 1.49E-7
7 SGTC_2252 omeprazole 5.04 400.0 µM 1.50E-6 2 2.34E-7
8 SGTC_1147 3809-1045 4.91 12.3 µM 2.61E-6 6 4.44E-7
9 SGTC_3098 9119039 4.82 49.5 µM 3.86E-6 Golgi 22 7.00E-7
10 SGTC_2627 acetyl isogambogic acid 4.78 100.0 µM 4.67E-6 TSC3-RPN4 29 8.72E-7
11 SGTC_2240 6690706 4.71 185.9 µM 6.37E-6 6 1.25E-6
12 SGTC_2019 4016004 4.68 108.0 µM 7.20E-6 11 1.44E-6
13 SGTC_1281 0884-0031 4.65 11.8 µM 8.20E-6 fatty acid desaturase (OLE1) 13 1.67E-6
14 SGTC_2155 5570423 4.63 76.0 µM 8.80E-6 ergosterol biosynthesis 6 1.81E-6
15 SGTC_2601 securinine 4.44 100.0 µM 1.95E-5 18 4.54E-6
16 SGTC_1776 st049249 4.43 45.9 µM 2.03E-5 10 4.74E-6
17 SGTC_2478 5763493 4.29 32.3 µM 3.52E-5 18 8.97E-6
18 SGTC_2461 5755302 4.28 26.1 µM 3.64E-5 25 9.32E-6
19 SGTC_2074 5212007 4.21 75.4 µM 4.75E-5 9 1.27E-5
20 SGTC_3011 9081274 4.18 71.4 µM 5.36E-5 11 1.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.076 9.99E-6 YPR087W_d VPS69_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect
0.070 5.01E-5 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.069 6.38E-5 YIL067C_p YIL067C_p hom Uncharacterized protein of unknown function
0.065 1.49E-4 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.063 2.47E-4 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.063 2.53E-4 YNL326C PFA3 hom Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.060 4.93E-4 YLR248W RCK2 hom Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication
0.060 5.45E-4 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.059 5.96E-4 YER132C PMD1 hom Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
0.058 8.13E-4 YIL109C SEC24 het Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.058 8.30E-4 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.057 9.02E-4 YOL155C HPF1 hom Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
0.057 9.33E-4 YJL127C SPT10 hom Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
0.057 9.98E-4 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.057 0.00101 YGL196W DSD1 hom D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate