YNL196C_p / SLZ1

Sporulation-specific protein with a leucine zipper motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL196C / SLZ1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.96|P-value:6.61E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.21|P-value:2.51E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.32|P-value:6.58E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.13|P-value:3.38E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.85|P-value:1.02E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.46|P-value:4.24E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-5.08|P-value:4.44E-7 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.97|P-value:5.96E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.22|P-value:9.47E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.63|P-value:3.95E-6 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.73|P-value:2.49E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.59|P-value:2.52E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.15|P-value:3.15E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.83|P-value:1.11E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.35|P-value:1.37E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:9.05|P-value:1.21E-18 ID:SGTC_1090|Compound:efavirenz|FD-Score:-4.06|P-value:4.25E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.25|P-value:8.21E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.32|P-value:1.55E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.38|P-value:5.68E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.33|P-value:6.26E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.86|P-value:9.92E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.61|P-value:2.48E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.59|P-value:2.64E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.21|P-value:2.40E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.80|P-value:1.22E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.35|P-value:6.17E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.90|P-value:8.32E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.34|P-value:1.44E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.63|P-value:2.28E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.30|P-value:7.28E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.79|P-value:1.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.01|P-value:5.41E-5 ID:SGTC_1558|Compound:st069300|FD-Score:5.40|P-value:9.49E-8 ID:SGTC_1567|Compound:st069303|FD-Score:3.61|P-value:2.52E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.28|P-value:7.83E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.56|P-value:2.96E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.72|P-value:2.63E-6 ID:SGTC_1897|Compound:st060201|FD-Score:5.44|P-value:7.47E-8 ID:SGTC_1903|Compound:st060211|FD-Score:4.28|P-value:1.85E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.39|P-value:5.46E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.63|P-value:2.31E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.41|P-value:5.03E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.46|P-value:8.58E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.22|P-value:9.64E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.45|P-value:4.24E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.20|P-value:9.63E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.29|P-value:1.77E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.28|P-value:7.93E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.38|P-value:5.69E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.18|P-value:2.77E-5 ID:SGTC_2817|Compound:7995342|FD-Score:5.38|P-value:1.06E-7 ID:SGTC_2824|Compound:7998404|FD-Score:6.62|P-value:8.21E-11 ID:SGTC_2841|Compound:9004761|FD-Score:-3.48|P-value:3.71E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.58|P-value:2.80E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.28|P-value:7.91E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.25|P-value:8.15E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.94|P-value:9.22E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-3.20|P-value:9.74E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.87|P-value:9.64E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.51|P-value:3.58E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.47|P-value:4.10E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.09|P-value:4.49E-7 ID:SGTC_3333|Compound:9141820|FD-Score:4.21|P-value:2.45E-5 ID:SGTC_3335|Compound:9143315|FD-Score:3.34|P-value:6.40E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.71|P-value:1.64E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.96|P-value:6.61E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.21|P-value:2.51E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.32|P-value:6.58E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.13|P-value:3.38E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.85|P-value:1.02E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.46|P-value:4.24E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-5.08|P-value:4.44E-7 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.97|P-value:5.96E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:3.22|P-value:9.47E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.63|P-value:3.95E-6 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.73|P-value:2.49E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.59|P-value:2.52E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.15|P-value:3.15E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.83|P-value:1.11E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.35|P-value:1.37E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:9.05|P-value:1.21E-18 ID:SGTC_1090|Compound:efavirenz|FD-Score:-4.06|P-value:4.25E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.25|P-value:8.21E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.32|P-value:1.55E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.38|P-value:5.68E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.33|P-value:6.26E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.86|P-value:9.92E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.61|P-value:2.48E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.59|P-value:2.64E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.21|P-value:2.40E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.80|P-value:1.22E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.35|P-value:6.17E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.90|P-value:8.32E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.34|P-value:1.44E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.63|P-value:2.28E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.30|P-value:7.28E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.79|P-value:1.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.01|P-value:5.41E-5 ID:SGTC_1558|Compound:st069300|FD-Score:5.40|P-value:9.49E-8 ID:SGTC_1567|Compound:st069303|FD-Score:3.61|P-value:2.52E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.28|P-value:7.83E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.56|P-value:2.96E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.72|P-value:2.63E-6 ID:SGTC_1897|Compound:st060201|FD-Score:5.44|P-value:7.47E-8 ID:SGTC_1903|Compound:st060211|FD-Score:4.28|P-value:1.85E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.39|P-value:5.46E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.63|P-value:2.31E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.41|P-value:5.03E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.46|P-value:8.58E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.22|P-value:9.64E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.45|P-value:4.24E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.20|P-value:9.63E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.29|P-value:1.77E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.28|P-value:7.93E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.38|P-value:5.69E-4 ID:SGTC_2813|Compound:7971799|FD-Score:4.18|P-value:2.77E-5 ID:SGTC_2817|Compound:7995342|FD-Score:5.38|P-value:1.06E-7 ID:SGTC_2824|Compound:7998404|FD-Score:6.62|P-value:8.21E-11 ID:SGTC_2841|Compound:9004761|FD-Score:-3.48|P-value:3.71E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.58|P-value:2.80E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.28|P-value:7.91E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.25|P-value:8.15E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.94|P-value:9.22E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-3.20|P-value:9.74E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.87|P-value:9.64E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.51|P-value:3.58E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.47|P-value:4.10E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.09|P-value:4.49E-7 ID:SGTC_3333|Compound:9141820|FD-Score:4.21|P-value:2.45E-5 ID:SGTC_3335|Compound:9143315|FD-Score:3.34|P-value:6.40E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.71|P-value:1.64E-4

Top fitness defect scores for YNL196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 9.05 424.9 nM 1.21E-18 DNA damage response 8 7.22E-20
2 SGTC_2824 7998404 6.62 52.0 µM 8.21E-11 5 1.76E-11
3 SGTC_1897 st060201 5.44 15.0 µM 7.47E-8 mitochondrial processes 6 2.60E-8
4 SGTC_1558 st069300 5.40 45.6 µM 9.49E-8 5 3.35E-8
5 SGTC_2817 7995342 5.38 71.4 µM 1.06E-7 6 3.77E-8
6 SGTC_58 0957-0393 5.21 9.0 µM 2.51E-7 cell wall 262 9.50E-8
7 SGTC_3133 9127736 5.09 49.5 µM 4.49E-7 6 1.77E-7
8 SGTC_2972 9093619 4.94 59.9 µM 9.22E-7 7 3.82E-7
9 SGTC_636 0kpi-0074 4.73 126.0 µM 2.49E-6 11 1.11E-6
10 SGTC_1889 st059080 4.72 5.2 µM 2.63E-6 7 1.17E-6
11 SGTC_568 1193-0097 4.63 7.5 µM 3.95E-6 ERAD & cell cycle 105 1.81E-6
12 SGTC_2257 7960413 4.46 200.0 µM 8.58E-6 NEO1-PIK1 39 4.16E-6
13 SGTC_1075 aripiprazole 4.35 15.2 µM 1.37E-5 17 6.86E-6
14 SGTC_1394 3474-0001 4.34 65.7 µM 1.44E-5 endomembrane recycling 31 7.26E-6
15 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.32 15.5 µM 1.55E-5 19 7.85E-6
16 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.29 100.0 µM 1.77E-5 12 9.04E-6
17 SGTC_1903 st060211 4.28 78.3 µM 1.85E-5 16 9.45E-6
18 SGTC_1264 0783-0040 4.21 158.0 µM 2.40E-5 19 1.25E-5
19 SGTC_3333 9141820 4.21 12.1 µM 2.45E-5 12 1.28E-5
20 SGTC_2813 7971799 4.18 71.4 µM 2.77E-5 17 1.45E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.08E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.120 2.58E-12 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.115 2.93E-11 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.108 4.09E-10 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.104 1.32E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.102 3.98E-9 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.100 5.60E-9 YPL255W BBP1 het Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
0.100 7.54E-9 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.097 1.66E-8 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.097 1.71E-8 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.097 1.78E-8 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.096 2.26E-8 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.095 3.34E-8 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.094 4.75E-8 YBR296C PHO89 hom Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification
0.094 4.82E-8 YCR049C_d YCR049C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data