YNL198C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL198C / YNL198C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.36|P-value:3.10E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.56|P-value:1.17E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.65|P-value:8.01E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.17|P-value:5.23E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.28|P-value:3.37E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.37|P-value:2.45E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.12|P-value:6.09E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.81|P-value:4.01E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.82|P-value:3.70E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.46|P-value:1.78E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.52|P-value:1.38E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.06|P-value:7.87E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-5.24|P-value:3.05E-8 ID:SGTC_393|Compound:acivicin|FD-Score:-4.10|P-value:1.14E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.25|P-value:5.11E-6 ID:SGTC_406|Compound:estrone|FD-Score:-3.08|P-value:7.28E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.27|P-value:4.81E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.83|P-value:3.56E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:4.29|P-value:4.22E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.46|P-value:7.52E-9 ID:SGTC_548|Compound:1436-0017|FD-Score:3.48|P-value:1.50E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.98|P-value:1.83E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.12|P-value:5.89E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.64|P-value:7.26E-7 ID:SGTC_729|Compound:4092-0585|FD-Score:3.04|P-value:7.97E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.15|P-value:5.61E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.08|P-value:7.02E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.11|P-value:6.56E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.80|P-value:4.09E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.11|P-value:1.09E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.15|P-value:8.30E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.03|P-value:8.76E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.88|P-value:2.84E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.51|P-value:1.45E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.68|P-value:1.95E-9 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-6.62|P-value:3.78E-12 ID:SGTC_1764|Compound:st044502|FD-Score:3.02|P-value:8.52E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.17|P-value:7.45E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-3.65|P-value:8.19E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.23|P-value:4.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-3.70|P-value:6.61E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-3.47|P-value:1.68E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.39|P-value:2.18E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.08|P-value:6.92E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.16|P-value:5.47E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_2324|Compound:6149169|FD-Score:5.86|P-value:6.26E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.29|P-value:4.37E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.87|P-value:5.70E-10 ID:SGTC_2620|Compound:irigenin|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.66|P-value:7.17E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.20|P-value:3.42E-8 ID:SGTC_2810|Compound:7959871|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.53|P-value:1.24E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.66|P-value:7.64E-5 ID:SGTC_3017|Compound:9080681|FD-Score:-3.73|P-value:5.70E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.01|P-value:8.99E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.12|P-value:6.10E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.19|P-value:4.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.36|P-value:3.10E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.56|P-value:1.17E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.65|P-value:8.01E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.17|P-value:5.23E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.28|P-value:3.37E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.37|P-value:2.45E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.18|P-value:5.03E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.12|P-value:6.09E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.81|P-value:4.01E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.82|P-value:3.70E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.46|P-value:1.78E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.52|P-value:1.38E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.06|P-value:7.87E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-5.24|P-value:3.05E-8 ID:SGTC_393|Compound:acivicin|FD-Score:-4.10|P-value:1.14E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.25|P-value:5.11E-6 ID:SGTC_406|Compound:estrone|FD-Score:-3.08|P-value:7.28E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.27|P-value:4.81E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.83|P-value:3.56E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:4.29|P-value:4.22E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.46|P-value:7.52E-9 ID:SGTC_548|Compound:1436-0017|FD-Score:3.48|P-value:1.50E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.98|P-value:1.83E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.12|P-value:5.89E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.64|P-value:7.26E-7 ID:SGTC_729|Compound:4092-0585|FD-Score:3.04|P-value:7.97E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.15|P-value:5.61E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.08|P-value:7.02E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.11|P-value:6.56E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.80|P-value:4.09E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.11|P-value:1.09E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.15|P-value:8.30E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.03|P-value:8.76E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.88|P-value:2.84E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.51|P-value:1.45E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.68|P-value:1.95E-9 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-6.62|P-value:3.78E-12 ID:SGTC_1764|Compound:st044502|FD-Score:3.02|P-value:8.52E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.17|P-value:7.45E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-3.65|P-value:8.19E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.23|P-value:4.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-3.70|P-value:6.61E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-3.47|P-value:1.68E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.39|P-value:2.18E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.08|P-value:6.92E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.16|P-value:5.47E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_2324|Compound:6149169|FD-Score:5.86|P-value:6.26E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.29|P-value:4.37E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.87|P-value:5.70E-10 ID:SGTC_2620|Compound:irigenin|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.66|P-value:7.17E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.20|P-value:3.42E-8 ID:SGTC_2810|Compound:7959871|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.53|P-value:1.24E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.66|P-value:7.64E-5 ID:SGTC_3017|Compound:9080681|FD-Score:-3.73|P-value:5.70E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.01|P-value:8.99E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.12|P-value:6.10E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.19|P-value:4.90E-4

Top fitness defect scores for YNL198C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2603 homopterocarpin 5.87 100.0 µM 5.70E-10 5 2.17E-9
2 SGTC_2324 6149169 5.86 200.0 µM 6.26E-10 4 2.36E-9
3 SGTC_1266 0828-0227 5.68 32.9 µM 1.95E-9 3 6.83E-9
4 SGTC_453 enantio-paf c16 5.46 10.0 µM 7.52E-9 70 2.40E-8
5 SGTC_2741 miltefosine 5.20 3.0 µM 3.42E-8 25 9.88E-8
6 SGTC_682 0kpi-0099 4.64 17.0 µM 7.26E-7 47 1.71E-6
7 SGTC_1239 0337-0584 4.51 35.4 µM 1.45E-6 unfolded protein response 41 3.26E-6
8 SGTC_58 0957-0393 4.36 9.0 µM 3.10E-6 cell wall 338 6.63E-6
9 SGTC_435 c-PAF 4.29 6.7 µM 4.22E-6 30 8.83E-6
10 SGTC_2489 cantharidin 4.29 73.4 µM 4.37E-6 cell wall signaling 34 9.12E-6
11 SGTC_408 cantharidin 4.27 100.0 µM 4.81E-6 cell wall signaling 16 9.97E-6
12 SGTC_403 arphamenine a 4.25 50.0 µM 5.11E-6 60S ribosome export 15 1.06E-5
13 SGTC_1766 st045414 4.17 44.8 µM 7.45E-6 RPP1 & pyrimidine depletion 18 1.50E-5
14 SGTC_1041 0206-0046 4.15 107.0 µM 8.30E-6 27 1.66E-5
15 SGTC_600 1495-0418 3.98 41.6 µM 1.83E-5 RPP1 & pyrimidine depletion 8 3.48E-5
16 SGTC_1214 0358-0031 3.88 63.7 µM 2.84E-5 21 5.24E-5
17 SGTC_415 dibenzyl ketone 3.83 100.0 µM 3.56E-5 12 6.46E-5
18 SGTC_257 daunorubicin 3.82 18.5 µM 3.70E-5 anthracycline transcription coupled DNA repair 22 6.70E-5
19 SGTC_948 3448-0295 3.80 75.3 µM 4.09E-5 30 7.36E-5
20 SGTC_843 0310-0051 3.73 143.0 µM 5.45E-5 17 9.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.50E-19 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 3.57E-19 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.133 1.16E-14 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.126 2.48E-13 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.119 4.74E-12 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.119 4.77E-12 YGR192C TDH3 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication
0.117 8.83E-12 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.113 6.05E-11 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.110 1.64E-10 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.109 2.51E-10 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.108 3.71E-10 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.107 4.57E-10 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.107 5.38E-10 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.107 5.52E-10 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.106 6.71E-10 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair