YNL199C / GCR2

Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL199C / GCR2

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.50|P-value:5.12E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.63|P-value:2.89E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.56|P-value:4.13E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.12|P-value:5.38E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:5.49|P-value:1.21E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:8.66|P-value:1.85E-16 ID:SGTC_166|Compound:k072-0058|FD-Score:4.70|P-value:5.01E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.71|P-value:2.45E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.61|P-value:3.54E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.77|P-value:2.02E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.43|P-value:1.39E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:4.90|P-value:2.07E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.61|P-value:3.51E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.84|P-value:1.38E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.14|P-value:5.12E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:5.85|P-value:1.89E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.18|P-value:4.29E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.56|P-value:4.19E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.48|P-value:1.12E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.72|P-value:2.35E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:4.94|P-value:1.69E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.47|P-value:5.71E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.69|P-value:2.67E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.91|P-value:1.22E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.11|P-value:7.87E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.00|P-value:8.60E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.64|P-value:2.80E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.54|P-value:4.50E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:6.36|P-value:1.09E-9 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.16|P-value:6.24E-7 ID:SGTC_1732|Compound:st034308|FD-Score:3.47|P-value:5.67E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.30|P-value:9.75E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.68|P-value:2.76E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.72|P-value:2.35E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.87|P-value:1.39E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.72|P-value:3.20E-8 ID:SGTC_2011|Compound:4012611|FD-Score:6.41|P-value:8.18E-10 ID:SGTC_2109|Compound:5483026|FD-Score:3.95|P-value:1.03E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.47|P-value:1.31E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.74|P-value:1.97E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.34|P-value:2.52E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.09|P-value:4.95E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.99|P-value:7.82E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.04|P-value:7.45E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.94|P-value:1.13E-8 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.38|P-value:2.10E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.11|P-value:3.75E-9 ID:SGTC_2702|Compound:st077768|FD-Score:3.38|P-value:7.57E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.99|P-value:2.38E-11 ID:SGTC_2788|Compound:5282734|FD-Score:3.35|P-value:8.44E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.43|P-value:5.71E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.48|P-value:5.51E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.42|P-value:1.62E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-4.14|P-value:4.39E-5 ID:SGTC_3301|Compound:9125354|FD-Score:3.52|P-value:4.84E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.47|P-value:5.01E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.50|P-value:5.12E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.63|P-value:2.89E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.56|P-value:4.13E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.12|P-value:5.38E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:5.49|P-value:1.21E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:8.66|P-value:1.85E-16 ID:SGTC_166|Compound:k072-0058|FD-Score:4.70|P-value:5.01E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.71|P-value:2.45E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.61|P-value:3.54E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.77|P-value:2.02E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.43|P-value:1.39E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:4.90|P-value:2.07E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.61|P-value:3.51E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.84|P-value:1.38E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.14|P-value:5.12E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:5.85|P-value:1.89E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.18|P-value:4.29E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.56|P-value:4.19E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.48|P-value:1.12E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.72|P-value:2.35E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:4.94|P-value:1.69E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.47|P-value:5.71E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.69|P-value:2.67E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.91|P-value:1.22E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.11|P-value:7.87E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.00|P-value:8.60E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.64|P-value:2.80E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.54|P-value:4.50E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:6.36|P-value:1.09E-9 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.16|P-value:6.24E-7 ID:SGTC_1732|Compound:st034308|FD-Score:3.47|P-value:5.67E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.30|P-value:9.75E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.68|P-value:2.76E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.72|P-value:2.35E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.87|P-value:1.39E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.72|P-value:3.20E-8 ID:SGTC_2011|Compound:4012611|FD-Score:6.41|P-value:8.18E-10 ID:SGTC_2109|Compound:5483026|FD-Score:3.95|P-value:1.03E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.47|P-value:1.31E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.74|P-value:1.97E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.34|P-value:2.52E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.09|P-value:4.95E-9 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.99|P-value:7.82E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.04|P-value:7.45E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.94|P-value:1.13E-8 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.38|P-value:2.10E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.11|P-value:3.75E-9 ID:SGTC_2702|Compound:st077768|FD-Score:3.38|P-value:7.57E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.99|P-value:2.38E-11 ID:SGTC_2788|Compound:5282734|FD-Score:3.35|P-value:8.44E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.43|P-value:5.71E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.48|P-value:5.51E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.42|P-value:1.62E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.60|P-value:3.65E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-4.14|P-value:4.39E-5 ID:SGTC_3301|Compound:9125354|FD-Score:3.52|P-value:4.84E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.47|P-value:5.01E-4

Top fitness defect scores for YNL199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_161 4065-0411 8.66 162.2 µM 1.85E-16 10 2.43E-18
2 SGTC_2741 miltefosine 6.99 3.0 µM 2.38E-11 16 1.36E-12
3 SGTC_2011 4012611 6.41 177.0 µM 8.18E-10 mitochondrial processes 5 7.24E-11
4 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 6.36 19.1 µM 1.09E-9 3 1.00E-10
5 SGTC_2582 agaric acid 6.09 100.0 µM 4.95E-9 redox potentiating 156 5.47E-10
6 SGTC_2612 dictamnine 5.94 15.5 µM 1.13E-8 RNA pol III & RNase P/MRP 12 1.38E-9
7 SGTC_825 1988-2224 5.85 89.6 µM 1.89E-8 cell wall signaling 16 2.47E-9
8 SGTC_98 0074-0023 5.49 107.7 µM 1.21E-7 Golgi 15 1.98E-8
9 SGTC_2658 polymyxin b sulfate 5.38 77.0 µM 2.10E-7 NEO1 25 3.69E-8
10 SGTC_2502 avocadyne acetate 5.34 18.6 µM 2.52E-7 11 4.54E-8
11 SGTC_1599 8-chlro-1-tetrahydronorharmanone 5.16 90.6 µM 6.24E-7 14 1.26E-7
12 SGTC_1425 4048-4433 5.11 7.3 µM 7.87E-7 copper-dependent oxidative stress 20 1.63E-7
13 SGTC_903 1134-0042 4.94 114.0 µM 1.69E-6 10 3.85E-7
14 SGTC_455 paf C-16 4.90 10.0 µM 2.07E-6 17 4.83E-7
15 SGTC_166 k072-0058 4.70 166.4 µM 5.01E-6 DNA intercalators 18 1.30E-6
16 SGTC_2249 haloperidol 4.47 116.4 µM 1.31E-5 ergosterol depletion effects on membrane 82 3.85E-6
17 SGTC_3093 9117344 4.42 49.5 µM 1.62E-5 60S ribosome export 8 4.88E-6
18 SGTC_832 4083-0019 4.18 164.0 µM 4.29E-5 translation 79 1.45E-5
19 SGTC_779 1360-0071 4.14 233.0 µM 5.12E-5 fatty acid desaturase (OLE1) 23 1.77E-5
20 SGTC_93 0109-0045 4.12 59.2 µM 5.38E-5 DNA damage response 38 1.87E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.08E-14 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.128 1.15E-13 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.126 2.72E-13 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.121 2.04E-12 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.120 2.67E-12 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.120 2.85E-12 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.118 5.88E-12 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.114 4.06E-11 YDR226W ADK1 hom Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress
0.113 5.44E-11 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.111 9.62E-11 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.111 1.35E-10 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.106 7.10E-10 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.106 7.07E-10 YDR207C UME6 hom Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.106 7.54E-10 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.106 7.75E-10 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress