YNL203C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL203C / YNL203C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.99|P-value:5.51E-19 ID:SGTC_442|Compound:cape|FD-Score:4.40|P-value:7.92E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.93|P-value:5.57E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.41|P-value:4.10E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-4.35|P-value:9.49E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:3.71|P-value:1.36E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.18|P-value:9.19E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.51|P-value:2.78E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.28|P-value:6.47E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.54|P-value:2.54E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.42|P-value:3.85E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.50|P-value:2.96E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:17.20|P-value:5.97E-64 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.21|P-value:1.79E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.27|P-value:6.83E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.49|P-value:3.13E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.95|P-value:5.44E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:4.20|P-value:1.94E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.42|P-value:3.93E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.89|P-value:7.91E-7 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.69|P-value:1.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.30|P-value:6.11E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.26|P-value:6.98E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:6.31|P-value:2.96E-10 ID:SGTC_1527|Compound:coumarin|FD-Score:4.43|P-value:6.84E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.90|P-value:6.44E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.91|P-value:7.37E-7 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.77|P-value:1.43E-6 ID:SGTC_1638|Compound:st008370|FD-Score:4.22|P-value:1.77E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.88|P-value:7.02E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.48|P-value:3.24E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.25|P-value:7.09E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.34|P-value:1.02E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.97|P-value:4.92E-5 ID:SGTC_1811|Compound:st050069|FD-Score:-3.15|P-value:9.75E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_1835|Compound:st008666|FD-Score:8.25|P-value:2.94E-16 ID:SGTC_1837|Compound:st055472|FD-Score:3.91|P-value:6.20E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.19|P-value:8.79E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.65|P-value:1.70E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.35|P-value:9.53E-6 ID:SGTC_1900|Compound:st060200|FD-Score:6.63|P-value:3.97E-11 ID:SGTC_1923|Compound:st058458|FD-Score:3.25|P-value:7.12E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.65|P-value:1.68E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.05|P-value:3.62E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.17|P-value:9.56E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.22|P-value:7.92E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.56|P-value:2.44E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.50|P-value:2.98E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_2353|Compound:9059630|FD-Score:5.57|P-value:2.35E-8 ID:SGTC_2447|Compound:5741742|FD-Score:3.15|P-value:9.92E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.18|P-value:8.98E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.18|P-value:8.93E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.97|P-value:4.98E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.67|P-value:1.59E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.71|P-value:1.34E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.29|P-value:1.27E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:6.73|P-value:2.04E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.45|P-value:6.40E-6 ID:SGTC_2834|Compound:9001755|FD-Score:3.28|P-value:6.50E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.28|P-value:6.28E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.22|P-value:7.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.20|P-value:8.46E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.31|P-value:5.83E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.31|P-value:5.87E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.16|P-value:9.44E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.19|P-value:8.54E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.21|P-value:8.19E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.22|P-value:7.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.99|P-value:5.51E-19 ID:SGTC_442|Compound:cape|FD-Score:4.40|P-value:7.92E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.93|P-value:5.57E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.41|P-value:4.10E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-4.35|P-value:9.49E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:3.71|P-value:1.36E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.18|P-value:9.19E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.51|P-value:2.78E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.28|P-value:6.47E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.54|P-value:2.54E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.42|P-value:3.85E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.50|P-value:2.96E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:17.20|P-value:5.97E-64 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.21|P-value:1.79E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.27|P-value:6.83E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.49|P-value:3.13E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.95|P-value:5.44E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:4.20|P-value:1.94E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:3.42|P-value:3.93E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.89|P-value:7.91E-7 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.69|P-value:1.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.30|P-value:6.11E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.26|P-value:6.98E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:6.31|P-value:2.96E-10 ID:SGTC_1527|Compound:coumarin|FD-Score:4.43|P-value:6.84E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.90|P-value:6.44E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.91|P-value:7.37E-7 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.77|P-value:1.43E-6 ID:SGTC_1638|Compound:st008370|FD-Score:4.22|P-value:1.77E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.88|P-value:7.02E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.48|P-value:3.24E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.25|P-value:7.09E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.34|P-value:1.02E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.97|P-value:4.92E-5 ID:SGTC_1811|Compound:st050069|FD-Score:-3.15|P-value:9.75E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_1835|Compound:st008666|FD-Score:8.25|P-value:2.94E-16 ID:SGTC_1837|Compound:st055472|FD-Score:3.91|P-value:6.20E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.19|P-value:8.79E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.65|P-value:1.70E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-4.35|P-value:9.53E-6 ID:SGTC_1900|Compound:st060200|FD-Score:6.63|P-value:3.97E-11 ID:SGTC_1923|Compound:st058458|FD-Score:3.25|P-value:7.12E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.65|P-value:1.68E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.05|P-value:3.62E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.17|P-value:9.56E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.22|P-value:7.92E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.56|P-value:2.44E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.50|P-value:2.98E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_2353|Compound:9059630|FD-Score:5.57|P-value:2.35E-8 ID:SGTC_2447|Compound:5741742|FD-Score:3.15|P-value:9.92E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.18|P-value:8.98E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.18|P-value:8.93E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.97|P-value:4.98E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.67|P-value:1.59E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.71|P-value:1.34E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.29|P-value:1.27E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:6.73|P-value:2.04E-11 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.45|P-value:6.40E-6 ID:SGTC_2834|Compound:9001755|FD-Score:3.28|P-value:6.50E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.28|P-value:6.28E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.22|P-value:7.63E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.20|P-value:8.46E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.31|P-value:5.83E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.31|P-value:5.87E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.16|P-value:9.44E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.19|P-value:8.54E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.21|P-value:8.19E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.22|P-value:7.73E-4

Top fitness defect scores for YNL203C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1013 4112-3890 17.20 241.0 µM 5.97E-64 TSC3-RPN4 2 2.59E-66
2 SGTC_58 0957-0393 8.99 9.0 µM 5.51E-19 cell wall 98 1.20E-19
3 SGTC_1835 st008666 8.25 49.2 µM 2.94E-16 4 8.11E-17
4 SGTC_2636 apigenin dimethyl ether 6.73 100.0 µM 2.04E-11 8 8.54E-12
5 SGTC_1900 st060200 6.63 72.8 µM 3.97E-11 3 1.71E-11
6 SGTC_1507 4075-3230 6.31 155.0 µM 2.96E-10 1 1.37E-10
7 SGTC_2353 9059630 5.57 146.7 µM 2.35E-8 3 1.29E-8
8 SGTC_1537 2',6'-dihydroxyflavanone 4.91 78.0 µM 7.37E-7 3 4.58E-7
9 SGTC_1157 4092-0394 4.89 27.6 µM 7.91E-7 12 4.93E-7
10 SGTC_1543 azetidyl-2-carboxylic acid 4.77 198.0 µM 1.43E-6 5 9.11E-7
11 SGTC_2639 lactacystin 4.45 53.0 µM 6.40E-6 15 4.31E-6
12 SGTC_1527 coumarin 4.43 137.0 µM 6.84E-6 13 4.62E-6
13 SGTC_442 cape 4.40 100.0 µM 7.92E-6 7 5.38E-6
14 SGTC_1803 st050068 4.34 52.4 µM 1.02E-5 NEO1-PIK1 151 6.99E-6
15 SGTC_1638 st008370 4.22 60.6 µM 1.77E-5 ergosterol biosynthesis 27 1.24E-5
16 SGTC_1023 4482-3888 4.21 16.0 µM 1.79E-5 TSC3-RPN4 12 1.25E-5
17 SGTC_1078 idebenone 4.20 36.1 µM 1.94E-5 Golgi 34 1.36E-5
18 SGTC_2043 5101342 4.05 149.0 µM 3.62E-5 SWF1 & branched chain AA biosynthesis 17 2.60E-5
19 SGTC_1804 st050076 3.97 49.1 µM 4.92E-5 17 3.57E-5
20 SGTC_2570 licareol 3.97 100.0 µM 4.98E-5 29 3.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.97E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.152 7.83E-19 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.147 1.04E-17 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.146 2.07E-17 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.145 3.27E-17 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.136 2.36E-15 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.129 5.23E-14 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 5.51E-14 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.127 1.28E-13 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.127 1.88E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.123 7.58E-13 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.122 1.18E-12 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.120 3.30E-12 YOR198C BFR1 hom Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
0.120 3.44E-12 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.118 7.42E-12 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate